Alu antisense RNA ameliorates methylglyoxal-induced human lens epithelial cell apoptosis by enhancing antioxidant defense

• Published in: International journal of ophthalmology Vol. 16; no. 2; pp. 178 - 190
• Main Authors: Wu, Pei-Yuan, Wu, Chong-Guang, Wang, Xiao-Die, Liu, Xin, Song, Zhi-Xue, Khan, Murad, Shah, Suleman, Du, Ying-Hua, Wang, Xiu-Fang, Yan, Li-Fang
• Format: Journal Article
• Language: English
• Published: China International Journal of Ophthalmology Press 18.02.2023; Press of International Journal of Ophthalmology (IJO PRESS)
• Subjects: antioxidant defense; apoptosis; Basic Research; human alu antisense rna; human lens epithelial cells; methylglyoxal toxicity; apoptosis; methylglyoxal toxicity; human lens epithelial cells; antioxidant defense; human Alu antisense RNA

AIM: To determine whether an antisense RNA corresponding to the human Alu transposable element (Aluas RNA) can protect human lens epithelial cells (HLECs) from methylglyoxal-induced apoptosis. METHODS: Cell counting kit-8 (CCK-8) and 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT)...