Lack of sedative and cognitive effects of diphenhydramine and cyclobenzaprine in elderly volunteers

• Published in: Journal of psychopharmacology (Oxford) Vol. 11; no. 4; p. 325
• Main Authors: Lines, C, Traub, M, Raskin, S, Mant, T, Reines, S
• Format: Journal Article
• Language: English
• Published: United States 1997
• Subjects: Aged; Aged, 80 and over; Amitriptyline - analogs & derivatives; Amitriptyline - pharmacology; Arousal - drug effects; Cognition - drug effects; Diphenhydramine - pharmacology; Double-Blind Method; Female; Humans; Hypnotics and Sedatives - pharmacology; Male; Middle Aged; Tranquilizing Agents - pharmacology

A double-blind, in-clinic, placebo-controlled, randomized, three-period crossover study was undertaken to investigate the potential sedative and cognitive effects of diphenhydramine 50 mg, p.o. and cyclobenzaprine 5 mg, p.o. in elderly volunteers. Subjects were given 10 doses of each treatment over...