An electrochemical lipopolysaccharide sensor based on an immobilized Toll-Like Receptor-4

• Published in: Biosensors & bioelectronics Vol. 87; pp. 794 - 801
• Main Authors: Mayall, R.M., Renaud-Young, M., Chan, N.W.C., Birss, V.I.
• Format: Journal Article
• Language: English
• Published: England Elsevier B.V 15.01.2017
• Subjects: Bacteria; Biosensing Techniques - methods; Biosensors; Charge transfer; Chromium; Electrochemical biosensor; Electrochemical Techniques - methods; Electrodes; Gram-negative bacteria; Gram-Negative Bacteria - immunology; Gram-Negative Bacteria - isolation & purification; Gram-Negative Bacterial Infections - immunology; Gram-Negative Bacterial Infections - microbiology; Humans; Immobilized Proteins - chemistry; Immobilized Proteins - immunology; Immune systems; Impedance spectroscopy; Lipopolysaccharide; Lipopolysaccharides - analysis; Lipopolysaccharides - immunology; Models, Molecular; Protein Multimerization; Proteins; Self-assembled monolayer; Sensors; Toll-Like Receptor 4 - chemistry; Toll-Like Receptor 4 - immunology; Toll-Like Receptor-4; Lipopolysaccharide; Self-assembled monolayer; Electrochemical biosensor; Impedance spectroscopy; Gram-negative bacteria; Toll-Like Receptor-4

Infections affect millions of people each year and yet methods to ascertain their cause can take more than 24h to be effective. This delay between the presentation with symptoms and the ability to make an informed decision about treatment can have adverse consequences, including death in severe case...