Pentose phosphate pathway coordinates multiple redox-controlled relaxing mechanisms in bovine coronary arteries

• Published in: American journal of physiology. Heart and circulatory physiology Vol. 285; no. 6; pp. H2316 - H2326
• Main Authors: Gupte, Sachin A, Arshad, Muhammad, Viola, Steven, Kaminski, Pawel M, Ungvari, Zoltan, Rabbani, Golam, Koller, Akos, Wolin, Michael S
• Format: Journal Article
• Language: English
• Published: United States 01.12.2003
• Subjects: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid - pharmacology; 6-Aminonicotinamide - pharmacology; Adenylyl Cyclase Inhibitors; Androsterone - pharmacology; Animals; Arteries - metabolism; Calcium - metabolism; Calcium - pharmacology; Calcium-Transporting ATPases - antagonists & inhibitors; Cattle; Coronary Vessels - metabolism; Dithiothreitol - pharmacology; Free Radical Scavengers - pharmacology; Fura-2; Glutathione - metabolism; Glutathione Disulfide - metabolism; Guanylate Cyclase; Hydrogen Peroxide - metabolism; NADP - metabolism; Pentose Phosphate Pathway - drug effects; Pentose Phosphate Pathway - physiology; Potassium Channel Blockers - pharmacology; Potassium Chloride - pharmacology; Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Serotonin - pharmacology; Soluble Guanylyl Cyclase; Superoxides - metabolism; Teratogens - pharmacology; Tetraethylammonium - pharmacology; Vasoconstrictor Agents - pharmacology; Vasodilation - drug effects; Vasodilation - physiology

Department of Physiology, New York Medical College, Valhalla, New York 10595 Submitted 20 March 2003 ; accepted in final form 31 July 2003 Pentose phosphate pathway (PPP) inhibitors, 6-aminonicotinamide (6-AN) and epiandrosterone (Epi), were employed to examine whether changes in NADP(H) redox regul...