Understanding the Renal Fibrotic Process in Leptospirosis

Leptospirosis is a neglected infectious disease caused by pathogenic species of the genus Leptospira. The acute disease is well-described, and, although it resembles other tropical diseases, it can be diagnosed through the use of serological and molecular methods. While the chronic renal disease, ca...

Full description

Saved in:
Bibliographic Details
Published inInternational journal of molecular sciences Vol. 22; no. 19; p. 10779
Main Authors Prado, Luan, Barbosa, Angela
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.10.2021
MDPI
Subjects
Bacteria
Communicable diseases
Cytokines
Extracellular matrix
Growth factors
Health aspects
Kidney diseases
Leptospirosis
Ligands
Mutation
Phosphorylation
Proteins
Review
Risk factors
Signal transduction
Online AccessGet full text

Cover

Abstract Leptospirosis is a neglected infectious disease caused by pathogenic species of the genus Leptospira. The acute disease is well-described, and, although it resembles other tropical diseases, it can be diagnosed through the use of serological and molecular methods. While the chronic renal disease, carrier state, and kidney fibrosis due to Leptospira infection in humans have been the subject of discussion by researchers, the mechanisms involved in these processes are still overlooked, and relatively little is known about the establishment and maintenance of the chronic status underlying this infectious disease. In this review, we highlight recent findings regarding the cellular communication pathways involved in the renal fibrotic process, as well as the relationship between renal fibrosis due to leptospirosis and CKD/CKDu.
AbstractList Leptospirosis is a neglected infectious disease caused by pathogenic species of the genus Leptospira. The acute disease is well-described, and, although it resembles other tropical diseases, it can be diagnosed through the use of serological and molecular methods. While the chronic renal disease, carrier state, and kidney fibrosis due to Leptospira infection in humans have been the subject of discussion by researchers, the mechanisms involved in these processes are still overlooked, and relatively little is known about the establishment and maintenance of the chronic status underlying this infectious disease. In this review, we highlight recent findings regarding the cellular communication pathways involved in the renal fibrotic process, as well as the relationship between renal fibrosis due to leptospirosis and CKD/CKDu.Leptospirosis is a neglected infectious disease caused by pathogenic species of the genus Leptospira. The acute disease is well-described, and, although it resembles other tropical diseases, it can be diagnosed through the use of serological and molecular methods. While the chronic renal disease, carrier state, and kidney fibrosis due to Leptospira infection in humans have been the subject of discussion by researchers, the mechanisms involved in these processes are still overlooked, and relatively little is known about the establishment and maintenance of the chronic status underlying this infectious disease. In this review, we highlight recent findings regarding the cellular communication pathways involved in the renal fibrotic process, as well as the relationship between renal fibrosis due to leptospirosis and CKD/CKDu.
Leptospirosis is a neglected infectious disease caused by pathogenic species of the genus Leptospira. The acute disease is well-described, and, although it resembles other tropical diseases, it can be diagnosed through the use of serological and molecular methods. While the chronic renal disease, carrier state, and kidney fibrosis due to Leptospira infection in humans have been the subject of discussion by researchers, the mechanisms involved in these processes are still overlooked, and relatively little is known about the establishment and maintenance of the chronic status underlying this infectious disease. In this review, we highlight recent findings regarding the cellular communication pathways involved in the renal fibrotic process, as well as the relationship between renal fibrosis due to leptospirosis and CKD/CKDu.
Leptospirosis is a neglected infectious disease caused by pathogenic species of the genus Leptospira . The acute disease is well-described, and, although it resembles other tropical diseases, it can be diagnosed through the use of serological and molecular methods. While the chronic renal disease, carrier state, and kidney fibrosis due to Leptospira infection in humans have been the subject of discussion by researchers, the mechanisms involved in these processes are still overlooked, and relatively little is known about the establishment and maintenance of the chronic status underlying this infectious disease. In this review, we highlight recent findings regarding the cellular communication pathways involved in the renal fibrotic process, as well as the relationship between renal fibrosis due to leptospirosis and CKD/CKDu.
Audience Academic
Author Barbosa, Angela
Prado, Luan
AuthorAffiliation 1 Laboratório de Bacteriologia, Instituto Butantan, Avenida Vital Brasil, 1500, São Paulo 05503-900, Brazil; luan.prado@esib.butantan.gov.br
2 Departamento de Microbiologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, Avenida Lineu Prestes 1374, São Paulo 05508-000, Brazil
AuthorAffiliation_xml – name: 1 Laboratório de Bacteriologia, Instituto Butantan, Avenida Vital Brasil, 1500, São Paulo 05503-900, Brazil; luan.prado@esib.butantan.gov.br
– name: 2 Departamento de Microbiologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, Avenida Lineu Prestes 1374, São Paulo 05508-000, Brazil
Author_xml – sequence: 1
  givenname: Luan
  surname: Prado
  fullname: Prado, Luan
– sequence: 2
  givenname: Angela
  orcidid: 0000-0002-6458-9489
  surname: Barbosa
  fullname: Barbosa, Angela
BookMark eNptkc9rHCEcxaWkND_aY-8DvfQyqX4dR70UQmiawkJLac7iON_ZuMzoVt1A__u6bEK7IXhQ9PPeF987JychBiTkPaOXnGv6yW-WDMA0o1LqV-SMdQAtpb08-e98Ss5z3lAKHIR-Q05513PNmDwj-i6MmHKxYfRh3ZR7bH5isHNz44cUi3fNjxQd5tz40KxwW2Le-hSzz2_J68nOGd897hfk7ubLr-vbdvX967frq1XrOqFL69wE4ATS3jouqO2cnDpwyoHSQ0cF6kHZEayivKfMwtSjkuAG20tgVgz8gnw--G53w4Kjw1CSnc02-cWmPyZab45fgr836_hglKBaMF4NPj4apPh7h7mYxWeH82wDxl02IBRTIEFBRT88Qzdxl2ocB4oC7Tv1j1rbGY0PU6xz3d7UXEnBldQC9l6XL1B1jbh4V0ucfL0_EvCDwNV8c8LJOF9s8XH_LT8bRs2-cXPUeFW1z1RPybzM_wWcs6yy
CitedBy_id crossref_primary_10_1007_s15010_025_02492_1
crossref_primary_10_3390_ijms23169233
crossref_primary_10_1097_MNH_0000000000000874
Cites_doi 10.12659/AOT.930066
10.1371/journal.pone.0102860
10.1016/S0960-9822(01)00290-1
10.1681/ASN.2003090795
10.1681/ASN.V13196
10.1038/ni.3858
10.1053/j.ajkd.2013.10.062
10.1186/1755-1536-7-16
10.1159/000312133
10.1242/dev.176073
10.3389/fphys.2021.606392
10.3389/fcimb.2018.00384
10.1097/01.ASN.0000098686.72971.DB
10.1038/sj.ki.5000246
10.2353/ajpath.2007.070166
10.1016/j.matbio.2020.04.005
10.1101/gad.1640608
10.1172/jci.insight.123563
10.1007/s00204-020-02829-9
10.1371/journal.pntd.0000228
10.1016/j.tcb.2017.04.005
10.1172/jci.insight.122912
10.1681/ASN.2006020159
10.1590/S0037-86822007000500002
10.1371/journal.pntd.0002664
10.1371/journal.pone.0015384
10.1038/39369
10.1038/sj.ki.4491416
10.1681/ASN.2016030354
10.1038/nrm2690
10.1016/j.immuni.2012.08.002
10.1038/s41580-020-0237-9
10.1128/IAI.01287-09
10.1007/978-3-662-45059-8
10.1007/s10096-019-03797-4
10.1101/cshperspect.a021907
10.3389/fimmu.2020.572999
10.1371/journal.pone.0148696
10.1016/j.mam.2018.06.002
10.1002/hep.26769
10.1159/000480691
10.1016/j.cyto.2016.12.025
10.1681/ASN.2008060566
10.1111/bph.15408
10.1016/j.bbrc.2015.11.092
10.1369/0022155419849388
10.1371/journal.pntd.0003898
10.1097/HJH.0b013e32833e4149
10.1016/j.devcel.2021.02.028
10.1016/j.yexcr.2013.07.014
10.1016/j.ejcb.2010.11.004
10.1016/j.biocel.2016.05.001
10.1371/journal.pone.0060471
10.1186/1756-0500-7-398
10.1111/nep.13472
10.1016/0006-291X(89)92316-4
10.1016/j.immuni.2019.03.024
10.1681/ASN.2006020185
10.1371/journal.pone.0147018
10.1111/j.1440-1746.2010.06549.x
10.1371/journal.pntd.0000612
10.1016/j.phrs.2019.104314
10.1152/ajprenal.1999.277.4.F624
10.1097/SHK.0b013e31828fae49
10.3389/fphys.2015.00082
10.1128/CMR.14.2.296-326.2001
10.1016/j.molcel.2012.12.002
10.1016/j.cbi.2018.07.008
10.1152/ajprenal.00199.2003
10.1016/j.cell.2016.06.028
10.1016/j.it.2018.11.007
10.1016/j.autrev.2014.11.013
10.1038/nm.3901
10.3109/08977194.2011.595714
10.1038/nrm3758
10.1371/journal.pntd.0003899
10.1038/nm.3218
10.1016/j.biocel.2007.11.026
10.1590/0103-1104202012616
10.1046/j.1523-1755.2001.0590041304.x
10.1159/000500388
10.1159/000488984
10.1038/nm.3902
10.1002/1873-3468.13768
10.1038/ni.1923
10.1038/342440a0
10.1016/S0092-8674(00)00141-0
10.1152/ajprenal.00268.2011
10.1038/ncb1722
10.1038/sj.onc.1208944
10.1038/aps.2014.134
10.3389/fcell.2020.00260
10.1080/10409238.2020.1828260
10.1097/01.ASN.0000141962.44300.3A
10.1080/08977190902834077
10.3389/fphar.2017.00461
10.1016/j.metabol.2019.154013
10.1038/nrmicro.2017.5
10.1038/kisup.2014.16
10.1006/jmcc.2000.1129
10.1038/ki.2011.255
10.1016/j.cyto.2015.12.013
10.1093/infdis/jit569
10.1146/annurev-physiol-022516-034339
10.18632/oncotarget.6604
10.1152/ajprenal.00357.2019
10.1083/jcb.200611146
10.1038/sj.onc.1210054
10.1006/bbrc.2001.6170
10.1371/journal.pone.0013614
10.1038/nrc2389
10.1371/journal.ppat.1007811
10.1242/jcs.00089
10.1152/ajprenal.00604.2016
10.1371/journal.pone.0174471
10.1038/srep44911
10.1016/S0140-6736(13)60687-X
10.1159/000491439
10.1016/S1097-2765(02)00439-2
10.1101/cshperspect.a005017
10.1016/j.molimm.2019.07.018
10.1111/j.1462-5822.2011.01660.x
10.1172/JCI117251
10.1074/jbc.C800074200
10.1038/cr.2008.324
10.1016/S1674-8301(11)60031-6
10.4172/2155-9597.1000120
10.1186/s12866-018-1206-8
10.3389/fcimb.2018.00063
10.1111/j.1523-1755.2004.00417.x
10.1038/ncb1728
10.1354/vp.08-VP-0265-N-REV
10.3390/ijerph111010366
10.3389/fimmu.2015.00262
10.7150/ijbs.7.1056
10.1038/sj.ki.5000054
10.1128/IAI.01115-15
10.1016/j.molcel.2009.06.018
10.1093/ndt/15.suppl_6.41
10.1038/ki.2011.158
10.1371/journal.pntd.0003927
10.1371/journal.pntd.0007458
10.4049/jimmunol.0900506
10.1074/jbc.M207848200
10.1093/ndt/gfn699
10.1016/S0140-6736(20)30045-3
10.1074/jbc.M710396200
10.1681/ASN.2016080902
10.1016/S1473-3099(03)00830-2
10.1152/ajprenal.00640.2020
10.1016/j.medmal.2012.11.005
10.1097/01.ASN.0000014252.37680.E4
10.1681/ASN.2017040391
10.1097/01.ASN.0000099373.33259.B2
10.1371/journal.pntd.0004668
10.1371/journal.pntd.0004105
10.1016/j.cimid.2018.11.009
ContentType Journal Article
Copyright COPYRIGHT 2021 MDPI AG
2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
2021 by the authors. 2021
Copyright_xml – notice: COPYRIGHT 2021 MDPI AG
– notice: 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
– notice: 2021 by the authors. 2021
DBID AAYXX
CITATION
3V.
7X7
7XB
88E
8FI
8FJ
8FK
8G5
ABUWG
AFKRA
AZQEC
BENPR
CCPQU
DWQXO
FYUFA
GHDGH
GNUQQ
GUQSH
K9.
M0S
M1P
M2O
MBDVC
PHGZM
PHGZT
PIMPY
PJZUB
PKEHL
PPXIY
PQEST
PQQKQ
PQUKI
PRINS
Q9U
7X8
5PM
DOI 10.3390/ijms221910779
DatabaseName CrossRef
ProQuest Central (Corporate)
ProQuest Health & Medical Collection (NC LIVE)
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Research Library
ProQuest Central (Alumni)
ProQuest Central UK/Ireland
ProQuest Central Essentials
ProQuest Central
ProQuest One Community College
ProQuest Central Korea
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
ProQuest Research Library
ProQuest Health & Medical Complete (Alumni)
ProQuest Health & Medical Collection
Medical Database
ProQuest Research Library (NC LIVE)
Research Library (Corporate)
ProQuest Central Premium
ProQuest One Academic
Publicly Available Content Database
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
ProQuest Central Basic
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle CrossRef
Publicly Available Content Database
Research Library Prep
ProQuest Central Student
ProQuest One Academic Middle East (New)
ProQuest Central Essentials
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest One Health & Nursing
Research Library (Alumni Edition)
ProQuest Central China
ProQuest Central
ProQuest Health & Medical Research Collection
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
Health & Medical Research Collection
ProQuest Research Library
ProQuest Central (New)
ProQuest Medical Library (Alumni)
ProQuest Central Basic
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
ProQuest Hospital Collection (Alumni)
ProQuest Health & Medical Complete
ProQuest Medical Library
ProQuest One Academic UKI Edition
ProQuest One Academic
ProQuest One Academic (New)
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList MEDLINE - Academic
Publicly Available Content Database


CrossRef
Database_xml – sequence: 1
  dbid: BENPR
  name: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 1422-0067
ExternalDocumentID PMC8509513
A753879522
10_3390_ijms221910779
GroupedDBID ---
29J
2WC
53G
5GY
5VS
7X7
88E
8FE
8FG
8FH
8FI
8FJ
8G5
A8Z
AADQD
AAFWJ
AAHBH
AAYXX
ABDBF
ABUWG
ACGFO
ACIHN
ACIWK
ACPRK
ACUHS
ADBBV
AEAQA
AENEX
AFKRA
AFZYC
ALMA_UNASSIGNED_HOLDINGS
AOIJS
AZQEC
BAWUL
BCNDV
BENPR
BPHCQ
BVXVI
CCPQU
CITATION
CS3
D1I
DIK
DU5
DWQXO
E3Z
EBD
EBS
EJD
ESX
F5P
FRP
FYUFA
GNUQQ
GUQSH
GX1
HH5
HMCUK
HYE
IAO
IHR
ITC
KQ8
LK8
M1P
M2O
M48
MODMG
O5R
O5S
OK1
OVT
P2P
PHGZM
PHGZT
PIMPY
PJZUB
PPXIY
PQQKQ
PROAC
PSQYO
RNS
RPM
TR2
TUS
UKHRP
~8M
ALIPV
PMFND
3V.
7XB
8FK
K9.
MBDVC
PKEHL
PQEST
PQUKI
PRINS
Q9U
7X8
5PM
ID FETCH-LOGICAL-c459t-ccf22c5e06ac350a4c7f42c8c289b405e9b8ad2a803601a2f6e872cba6721a5b3
IEDL.DBID M48
ISSN 1422-0067
1661-6596
IngestDate Thu Aug 21 17:36:39 EDT 2025
Thu Jul 10 19:18:06 EDT 2025
Fri Jul 25 09:32:04 EDT 2025
Tue Jun 17 20:48:34 EDT 2025
Tue Jun 10 20:14:01 EDT 2025
Wed Aug 20 07:46:11 EDT 2025
Thu Apr 24 23:05:32 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 19
Language English
License Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c459t-ccf22c5e06ac350a4c7f42c8c289b405e9b8ad2a803601a2f6e872cba6721a5b3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Review-3
content type line 23
ORCID 0000-0002-6458-9489
OpenAccessLink http://journals.scholarsportal.info/openUrl.xqy?doi=10.3390/ijms221910779
PMID 34639117
PQID 2581020648
PQPubID 2032341
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_8509513
proquest_miscellaneous_2581827282
proquest_journals_2581020648
gale_infotracmisc_A753879522
gale_infotracacademiconefile_A753879522
crossref_citationtrail_10_3390_ijms221910779
crossref_primary_10_3390_ijms221910779
PublicationCentury 2000
PublicationDate 2021-10-01
PublicationDateYYYYMMDD 2021-10-01
PublicationDate_xml – month: 10
  year: 2021
  text: 2021-10-01
  day: 01
PublicationDecade 2020
PublicationPlace Basel
PublicationPlace_xml – name: Basel
PublicationTitle International journal of molecular sciences
PublicationYear 2021
Publisher MDPI AG
MDPI
Publisher_xml – name: MDPI AG
– name: MDPI
References Bharti (ref_2) 2003; 3
Li (ref_60) 2002; 13
Santecchia (ref_154) 2017; 8
Wang (ref_158) 2015; 7
ref_13
ref_10
Chung (ref_24) 2018; 3
Niehrs (ref_89) 2006; 25
Han (ref_33) 2019; 4
Chou (ref_25) 2021; 320
Zhou (ref_93) 2017; 28
Fraga (ref_95) 2014; 209
Vieira (ref_164) 2019; 62
Picardeau (ref_4) 2017; 15
Djudjaj (ref_18) 2019; 65
Chassin (ref_156) 2009; 183
ref_125
Wicks (ref_48) 2005; 24
Robertson (ref_56) 2016; 8
Hosper (ref_133) 2013; 319
Ermert (ref_99) 2019; 114
Iekushi (ref_75) 2010; 28
ref_23
Gong (ref_78) 2006; 17
Marteli (ref_11) 2020; 44
Dworkin (ref_34) 2004; 65
Hume (ref_147) 2019; 40
Boor (ref_17) 2019; 67
Huelsken (ref_27) 2002; 115
Imamura (ref_74) 2017; 98
LeBleu (ref_129) 2013; 19
Barbosa (ref_96) 2020; 594
Hu (ref_41) 2018; 292
Batlle (ref_45) 2019; 50
Markiewski (ref_102) 2007; 171
ref_72
Miyazawa (ref_109) 1989; 163
Bao (ref_107) 2011; 80
ref_151
ref_150
Carroll (ref_98) 2012; 37
ref_152
Ilangumaran (ref_111) 2016; 82
Nieto (ref_131) 2016; 166
Routledge (ref_88) 2019; 146
Deheuninck (ref_64) 2009; 19
ref_160
Xavier (ref_104) 2017; 312
Wang (ref_29) 2011; 80
Richer (ref_153) 2015; 83
Albino (ref_149) 2021; 12
Dias (ref_12) 2007; 40
Danobeitia (ref_106) 2014; 7
Park (ref_139) 2008; 22
Chung (ref_63) 2009; 24
Nakamura (ref_70) 2011; 26
Nair (ref_146) 2021; 11
Yamaguchi (ref_145) 2018; 18
ref_140
Heesterbeek (ref_97) 2018; 10
ref_143
Yang (ref_120) 2005; 16
Monahan (ref_162) 2009; 46
Klaus (ref_84) 2008; 8
Nakao (ref_61) 1997; 389
Picardeau (ref_9) 2013; 43
Korpal (ref_138) 2008; 283
Kang (ref_49) 2008; 10
Shen (ref_110) 2000; 103
Werts (ref_155) 2019; 7
Gracie (ref_14) 2014; 11
Tamai (ref_90) 2001; 11
Wang (ref_115) 2002; 9
Yang (ref_128) 2020; 21
Ma (ref_113) 2014; 59
Xu (ref_123) 2017; 7
Lovisa (ref_135) 2015; 21
Levett (ref_3) 2001; 14
Yang (ref_76) 2002; 13
ref_52
Mizuno (ref_38) 2001; 59
Tan (ref_30) 2014; 4
Bavia (ref_94) 2018; 8
Ricklin (ref_101) 2010; 11
Jenkins (ref_57) 2008; 40
ref_59
Feng (ref_26) 2018; 29
Liu (ref_54) 2009; 35
Xavier (ref_92) 2019; 317
Murray (ref_148) 2017; 79
Liu (ref_47) 2016; 76
Kagami (ref_126) 1994; 93
Lamouille (ref_67) 2007; 178
Yang (ref_65) 2003; 14
Li (ref_91) 2021; 26
Mohammed (ref_5) 2011; 2
Budi (ref_22) 2017; 27
ref_66
Li (ref_119) 2019; 12
ref_163
Mizuno (ref_40) 2004; 286
(ref_82) 2014; 2014
Katsuno (ref_42) 2021; 56
He (ref_85) 2009; 20
Zuo (ref_51) 2013; 49
Portilla (ref_103) 2021; 178
Biernacka (ref_43) 2011; 29
Nakamura (ref_108) 1989; 342
Lan (ref_44) 2011; 7
Tian (ref_157) 2011; 79
Karpagam (ref_8) 2020; 39
Mizuno (ref_37) 2000; 57
Bektas (ref_53) 2011; 25
Kaibori (ref_118) 2002; 290
Wesseling (ref_165) 2014; 63
Spit (ref_62) 2020; 55
Gong (ref_35) 2003; 14
Gregory (ref_137) 2008; 10
Liu (ref_31) 2011; 124
Munger (ref_55) 2011; 3
Ferrer (ref_142) 2018; 8
Balakumar (ref_127) 2019; 146
Seguro (ref_141) 2013; 39
Merle (ref_100) 2015; 6
Herath (ref_161) 2014; 7
Reis (ref_15) 2008; 2
Xiong (ref_136) 2012; 302
Takane (ref_114) 2003; 278
Esposito (ref_117) 2009; 27
Pyo (ref_86) 2020; 94
Zuo (ref_28) 2018; 23
Hajishengallis (ref_105) 2017; 18
Bikbov (ref_159) 2020; 395
Grande (ref_130) 2015; 21
Lamouille (ref_68) 2014; 15
Tian (ref_132) 2006; 17
Zhou (ref_87) 2017; 28
Yang (ref_16) 2018; 138
Wei (ref_116) 2021; 50
Inoue (ref_36) 2003; 17
Gong (ref_124) 2016; 469
Xu (ref_39) 2018; 22
Molnarfi (ref_69) 2015; 14
Lijnen (ref_121) 2000; 32
Meng (ref_46) 2015; 6
You (ref_134) 2019; 10
Ma (ref_58) 2020; 8
Gong (ref_79) 2006; 69
ref_1
Li (ref_32) 2015; 36
Gong (ref_71) 2008; 283
Daha (ref_80) 2000; 15
Schaale (ref_83) 2011; 90
AlQudah (ref_122) 2020; 91–92
Toma (ref_144) 2011; 13
Xu (ref_21) 2020; 103
Liu (ref_20) 2006; 69
Gong (ref_77) 2004; 15
Ito (ref_73) 2010; 152
Rotin (ref_50) 2009; 10
Jha (ref_19) 2013; 382
ref_7
Feng (ref_81) 2018; 4
Liu (ref_112) 1999; 277
ref_6
References_xml – volume: 26
  start-page: e930066-1
  year: 2021
  ident: ref_91
  article-title: Klotho Regulates Epithelial-to-Mesenchymal Transition In Vitro via Wnt/β-Catenin Pathway and Attenuates Chronic Allograft Dysfunction in a Rat Renal Transplant Model
  publication-title: Ann. Transpl.
  doi: 10.12659/AOT.930066
– ident: ref_150
  doi: 10.1371/journal.pone.0102860
– volume: 11
  start-page: 951
  year: 2001
  ident: ref_90
  article-title: Head Inducer Dickkopf-1 Is a Ligand for Wnt Coreceptor LRP6
  publication-title: Curr. Biol.
  doi: 10.1016/S0960-9822(01)00290-1
– volume: 16
  start-page: 68
  year: 2005
  ident: ref_120
  article-title: A Novel Mechanism by Which Hepatocyte Growth Factor Blocks Tubular Epithelial to Mesenchymal Transition
  publication-title: J. Am. Soc. Nephrol.
  doi: 10.1681/ASN.2003090795
– volume: 13
  start-page: 96
  year: 2002
  ident: ref_76
  article-title: Blockage of Tubular Epithelial to Myofibroblast Transition by Hepatocyte Growth Factor Prevents Renal Interstitial Fibrosis
  publication-title: J. Am. Soc. Nephrol.
  doi: 10.1681/ASN.V13196
– volume: 18
  start-page: 1288
  year: 2017
  ident: ref_105
  article-title: Novel Mechanisms and Functions of Complement
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.3858
– volume: 63
  start-page: 506
  year: 2014
  ident: ref_165
  article-title: CKD of Unknown Origin in Central America: The Case for a Mesoamerican Nephropathy
  publication-title: Am. J. Kidney Dis.
  doi: 10.1053/j.ajkd.2013.10.062
– volume: 7
  start-page: 16
  year: 2014
  ident: ref_106
  article-title: The Role of Complement in the Pathogenesis of Renal Ischemia-Reperfusion Injury and Fibrosis
  publication-title: Fibrogenesis Tissue Repair
  doi: 10.1186/1755-1536-7-16
– volume: 152
  start-page: 96
  year: 2010
  ident: ref_73
  article-title: Effect of the Hepatocyte Growth Factor on Allergic Inflammatory Cells
  publication-title: Int. Arch. Allergy Immunol.
  doi: 10.1159/000312133
– volume: 146
  start-page: dev176073
  year: 2019
  ident: ref_88
  article-title: Mechanisms of Intercellular Wnt Transport
  publication-title: Development
  doi: 10.1242/dev.176073
– volume: 12
  start-page: 606392
  year: 2021
  ident: ref_149
  article-title: Renal Inflammation and Innate Immune Activation Underlie the Transition From Gentamicin-Induced Acute Kidney Injury to Renal Fibrosis
  publication-title: Front. Physiol.
  doi: 10.3389/fphys.2021.606392
– volume: 8
  start-page: 384
  year: 2018
  ident: ref_142
  article-title: Macrophages and Galectin 3 Control Bacterial Burden in Acute and Subacute Murine Leptospirosis That Determines Chronic Kidney Fibrosis
  publication-title: Front. Cell. Infect. Microbiol.
  doi: 10.3389/fcimb.2018.00384
– volume: 14
  start-page: 3047
  year: 2003
  ident: ref_35
  article-title: Hepatocyte Growth Factor Modulates Matrix Metalloproteinases and Plasminogen Activator/Plasmin Proteolytic Pathways in Progressive Renal Interstitial Fibrosis
  publication-title: J. Am. Soc. Nephrol.
  doi: 10.1097/01.ASN.0000098686.72971.DB
– volume: 69
  start-page: 1166
  year: 2006
  ident: ref_79
  article-title: Hepatocyte Growth Factor Suppresses Acute Renal Inflammation by Inhibition of Endothelial E-Selectin
  publication-title: Kidney Int.
  doi: 10.1038/sj.ki.5000246
– volume: 17
  start-page: 268
  year: 2003
  ident: ref_36
  article-title: Hepatocyte Growth Factor Counteracts Transforming Growth Factor-Beta1, through Attenuation of Connective Tissue Growth Factor Induction, and Prevents Renal Fibrogenesis in 5/6 Nephrectomized Mice
  publication-title: FASEB J. Off. Publ. Fed. Am. Soc. Exp. Biol.
– volume: 171
  start-page: 715
  year: 2007
  ident: ref_102
  article-title: The Role of Complement in Inflammatory Diseases From Behind the Scenes into the Spotlight
  publication-title: Am. J. Pathol.
  doi: 10.2353/ajpath.2007.070166
– volume: 91–92
  start-page: 92
  year: 2020
  ident: ref_122
  article-title: Targeting the Renin-Angiotensin-Aldosterone System in Fibrosis
  publication-title: Matrix Biol.
  doi: 10.1016/j.matbio.2020.04.005
– volume: 22
  start-page: 894
  year: 2008
  ident: ref_139
  article-title: The MiR-200 Family Determines the Epithelial Phenotype of Cancer Cells by Targeting the E-Cadherin Repressors ZEB1 and ZEB2
  publication-title: Genes Dev.
  doi: 10.1101/gad.1640608
– volume: 10
  start-page: 14
  year: 2019
  ident: ref_134
  article-title: FKN Facilitates HK-2 Cell EMT and Tubulointerstitial Lesions via the Wnt/β-Catenin Pathway in a Murine Model of Lupus Nephritis
  publication-title: Front. Immunol.
– volume: 3
  start-page: e123563
  year: 2018
  ident: ref_24
  article-title: TGF-β Promotes Fibrosis after Severe Acute Kidney Injury by Enhancing Renal Macrophage Infiltration
  publication-title: JCI Insight
  doi: 10.1172/jci.insight.123563
– volume: 94
  start-page: 3329
  year: 2020
  ident: ref_86
  article-title: Ochratoxin A Induces Epithelial-to-Mesenchymal Transition and Renal Fibrosis through TGF-β/Smad2/3 and Wnt1/β-Catenin Signaling Pathways in Vitro and in Vivo
  publication-title: Arch. Toxicol.
  doi: 10.1007/s00204-020-02829-9
– volume: 2
  start-page: 11
  year: 2008
  ident: ref_15
  article-title: Impact of Environment and Social Gradient on Leptospira Infection in Urban Slums
  publication-title: PLoS Negl. Trop. Dis.
  doi: 10.1371/journal.pntd.0000228
– volume: 12
  start-page: 933
  year: 2019
  ident: ref_119
  article-title: The Balance between HGF and TGF-Β1 Acts as a Switch in the Tissue Remodeling of Chronic Rhinosinusitis
  publication-title: Int. J. Clin. Exp. Pathol.
– volume: 27
  start-page: 658
  year: 2017
  ident: ref_22
  article-title: Transforming Growth Factor-β Receptors and Smads: Regulatory Complexity and Functional Versatility
  publication-title: Trends Cell Biol.
  doi: 10.1016/j.tcb.2017.04.005
– volume: 4
  start-page: e122912
  year: 2019
  ident: ref_33
  article-title: C3a and SuPAR Drive Versican V1 Expression in Tubular Cells of Focal Segmental Glomerulosclerosis
  publication-title: JCI Insight
  doi: 10.1172/jci.insight.122912
– volume: 17
  start-page: 2792
  year: 2006
  ident: ref_132
  article-title: Leptospiral Outer Membrane Protein Induces Extracellular Matrix Accumulation through a TGF-Β1/Smad-Dependent Pathway
  publication-title: J. Am. Soc. Nephrol.
  doi: 10.1681/ASN.2006020159
– volume: 40
  start-page: 499
  year: 2007
  ident: ref_12
  article-title: Factors Associated with Leptospira Sp Infection in a Large Urban Center in Northeastern Brazil
  publication-title: Rev. Soc. Bras. Med. Trop.
  doi: 10.1590/S0037-86822007000500002
– ident: ref_152
  doi: 10.1371/journal.pntd.0002664
– ident: ref_72
  doi: 10.1371/journal.pone.0015384
– volume: 389
  start-page: 631
  year: 1997
  ident: ref_61
  article-title: Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling
  publication-title: Nature
  doi: 10.1038/39369
– volume: 57
  start-page: 937
  year: 2000
  ident: ref_37
  article-title: Reciprocal Balance of Hepatocyte Growth Factor and Transforming Growth Factor-Β1 in Renal Fibrosis in Mice
  publication-title: Kidney Int.
  doi: 10.1038/sj.ki.4491416
– volume: 28
  start-page: 598
  year: 2017
  ident: ref_93
  article-title: Matrix Metalloproteinase-7 Is a Urinary Biomarker and Pathogenic Mediator of Kidney Fibrosis
  publication-title: J. Am. Soc. Nephrol.
  doi: 10.1681/ASN.2016030354
– volume: 10
  start-page: 398
  year: 2009
  ident: ref_50
  article-title: Physiological Functions of the HECT Family of Ubiquitin Ligases
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/nrm2690
– volume: 37
  start-page: 199
  year: 2012
  ident: ref_98
  article-title: Regulation of Humoral Immunity by Complement
  publication-title: Immunity
  doi: 10.1016/j.immuni.2012.08.002
– volume: 21
  start-page: 341
  year: 2020
  ident: ref_128
  article-title: Guidelines and Definitions for Research on Epithelial–Mesenchymal Transition
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/s41580-020-0237-9
– volume: 79
  start-page: 9
  year: 2011
  ident: ref_157
  article-title: Leptospira Santorosai Serovar Shermani Detergent Extract Induces an Increase in Fibronectin Production through a Toll-Like Receptor 2-Mediated Pathway
  publication-title: Infect. Immun.
  doi: 10.1128/IAI.01287-09
– ident: ref_1
  doi: 10.1007/978-3-662-45059-8
– volume: 39
  start-page: 835
  year: 2020
  ident: ref_8
  article-title: Leptospirosis: A Neglected Tropical Zoonotic Infection of Public Health Importance—An Updated Review
  publication-title: Eur. J. Clin. Microbiol. Infect. Dis.
  doi: 10.1007/s10096-019-03797-4
– volume: 8
  start-page: a021907
  year: 2016
  ident: ref_56
  article-title: Regulation of the Bioavailability of TGF-β and TGF-β-Related Proteins
  publication-title: Cold Spring Harb. Perspect. Biol.
  doi: 10.1101/cshperspect.a021907
– volume: 11
  start-page: 572999
  year: 2021
  ident: ref_146
  article-title: Role of TLR4 in Persistent Leptospira Interrogans Infection: A Comparative In Vivo Study in Mice
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2020.572999
– ident: ref_125
  doi: 10.1371/journal.pone.0148696
– volume: 65
  start-page: 16
  year: 2019
  ident: ref_18
  article-title: Cellular and Molecular Mechanisms of Kidney Fibrosis
  publication-title: Mol. Asp. Med.
  doi: 10.1016/j.mam.2018.06.002
– volume: 59
  start-page: 2010
  year: 2014
  ident: ref_113
  article-title: Novel Death Defying Domain in Met Entraps the Active Site of Caspase-3 and Blocks Apoptosis in Hepatocytes: Ma et Al
  publication-title: Hepatology
  doi: 10.1002/hep.26769
– volume: 138
  start-page: 129
  year: 2018
  ident: ref_16
  article-title: Leptospirosis Renal Disease: Emerging Culprit of Chronic Kidney Disease Unknown Etiology
  publication-title: Nephron
  doi: 10.1159/000480691
– volume: 98
  start-page: 97
  year: 2017
  ident: ref_74
  article-title: Hepatocyte Growth Factor in Physiology and Infectious Diseases
  publication-title: Cytokine
  doi: 10.1016/j.cyto.2016.12.025
– volume: 20
  start-page: 765
  year: 2009
  ident: ref_85
  article-title: Wnt/β-Catenin Signaling Promotes Renal Interstitial Fibrosis
  publication-title: J. Am. Soc. Nephrol.
  doi: 10.1681/ASN.2008060566
– volume: 178
  start-page: 2880
  year: 2021
  ident: ref_103
  article-title: Role of Intracellular Complement Activation in Kidney Fibrosis
  publication-title: Br. J. Pharmacol.
  doi: 10.1111/bph.15408
– volume: 469
  start-page: 183
  year: 2016
  ident: ref_124
  article-title: Silencing of Angiotensin II Type-1 Receptor Inhibits High Glucose-Induced Epithelial-Mesenchymal Transition in Human Renal Proximal Tubular Epithelial Cells via Inactivation of MTOR/P70S6K Signaling Pathway
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1016/j.bbrc.2015.11.092
– volume: 67
  start-page: 643
  year: 2019
  ident: ref_17
  article-title: Extracellular Matrix in Kidney Fibrosis: More Than Just a Scaffold
  publication-title: J. Histochem. Cytochem.
  doi: 10.1369/0022155419849388
– ident: ref_7
  doi: 10.1371/journal.pntd.0003898
– volume: 28
  start-page: 2454
  year: 2010
  ident: ref_75
  article-title: Hepatocyte Growth Factor Attenuates Renal FIbrosis through TGF-B1 Suppression by Apoptosis of Myofibroblasts
  publication-title: J. Hypertens.
  doi: 10.1097/HJH.0b013e32833e4149
– volume: 56
  start-page: 726
  year: 2021
  ident: ref_42
  article-title: Epithelial Plasticity, Epithelial-Mesenchymal Transition, and the TGF-β Family
  publication-title: Dev. Cell
  doi: 10.1016/j.devcel.2021.02.028
– volume: 319
  start-page: 3000
  year: 2013
  ident: ref_133
  article-title: Epithelial-to-Mesenchymal Transition in Fibrosis_ Collagen Type I Expression Is Highly Upregulated after EMT, but Does Not Contribute to Collagen Deposition
  publication-title: Exp. Cell Res.
  doi: 10.1016/j.yexcr.2013.07.014
– volume: 90
  start-page: 553
  year: 2011
  ident: ref_83
  article-title: Wnt Signaling in Macrophages: Augmenting and Inhibiting Mycobacteria-Induced Inflammatory Responses
  publication-title: Eur. J. Cell Biol.
  doi: 10.1016/j.ejcb.2010.11.004
– volume: 76
  start-page: 135
  year: 2016
  ident: ref_47
  article-title: Regulation of the TGF-β Pathway by Deubiquitinases in Cancer
  publication-title: Int. J. Biochem. Cell Biol.
  doi: 10.1016/j.biocel.2016.05.001
– ident: ref_52
  doi: 10.1371/journal.pone.0060471
– volume: 7
  start-page: 1
  year: 2014
  ident: ref_161
  article-title: Long Term Outcome of Acute Kidney Injury Due to Leptospirosis? A Longitudinal Study in Sri Lanka
  publication-title: BMC Res. Notes
  doi: 10.1186/1756-0500-7-398
– volume: 23
  start-page: 38
  year: 2018
  ident: ref_28
  article-title: New Insights into the Role and Mechanism of Wnt/β-Catenin Signalling in Kidney Fibrosis
  publication-title: Nephrology
  doi: 10.1111/nep.13472
– volume: 163
  start-page: 967
  year: 1989
  ident: ref_109
  article-title: Molecular Cloning and Sequence Analysis of CDNA for Human Hepatocyte Growth Factor
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1016/0006-291X(89)92316-4
– volume: 50
  start-page: 924
  year: 2019
  ident: ref_45
  article-title: Transforming Growth Factor-β Signaling in Immunity and Cancer
  publication-title: Immunity
  doi: 10.1016/j.immuni.2019.03.024
– volume: 17
  start-page: 2464
  year: 2006
  ident: ref_78
  article-title: Anti-Inflammatory Effect of Hepatocyte Growth Factor in Chronic Kidney Disease: Targeting the Inflamed Vascular Endothelium
  publication-title: J. Am. Soc. Nephrol.
  doi: 10.1681/ASN.2006020185
– volume: 2014
  start-page: 310183
  year: 2014
  ident: ref_82
  article-title: The Wnt/β-Catenin Signaling Pathway Controls the Inflammatory Response in Infections Caused by Pathogenic Bacteria
  publication-title: Mediat. Inflamm.
– ident: ref_23
  doi: 10.1371/journal.pone.0147018
– volume: 26
  start-page: 188
  year: 2011
  ident: ref_70
  article-title: Hepatocyte Growth Factor Twenty Years on: Much More than a Growth Factor
  publication-title: J. Gastroenterol. Hepatol.
  doi: 10.1111/j.1440-1746.2010.06549.x
– ident: ref_160
  doi: 10.1371/journal.pntd.0000612
– volume: 146
  start-page: 104314
  year: 2019
  ident: ref_127
  article-title: A Potential Role of the Renin-Angiotensin-Aldosterone System in Epithelial-to-Mesenchymal Transition-Induced Renal Abnormalities_ Mechanisms and Therapeutic Implications
  publication-title: Pharmacol. Res.
  doi: 10.1016/j.phrs.2019.104314
– volume: 277
  start-page: F624
  year: 1999
  ident: ref_112
  article-title: Hepatocyte Growth Factor Promotes Renal Epithelial Cell Survival by Dual Mechanisms
  publication-title: Am. J. Physiol.-Ren. Physiol.
  doi: 10.1152/ajprenal.1999.277.4.F624
– volume: 39
  start-page: 17
  year: 2013
  ident: ref_141
  article-title: Pathophysiology of Leptospirosis
  publication-title: Shock
  doi: 10.1097/SHK.0b013e31828fae49
– volume: 6
  start-page: 82
  year: 2015
  ident: ref_46
  article-title: TGF-ß/Smad Signaling in Renal Fibrosis
  publication-title: Front. Physiol.
  doi: 10.3389/fphys.2015.00082
– volume: 14
  start-page: 296
  year: 2001
  ident: ref_3
  article-title: Leptospirosis
  publication-title: Clin. Microbiol. Rev.
  doi: 10.1128/CMR.14.2.296-326.2001
– volume: 49
  start-page: 499
  year: 2013
  ident: ref_51
  article-title: C-Cbl-Mediated Neddylation Antagonizes Ubiquitination and Degradation of the TGF-β Type II Receptor
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2012.12.002
– volume: 292
  start-page: 76
  year: 2018
  ident: ref_41
  article-title: New Insights into TGF-β/Smad Signaling in Tissue Fibrosis
  publication-title: Chem.-Biol. Interact.
  doi: 10.1016/j.cbi.2018.07.008
– volume: 286
  start-page: 134
  year: 2004
  ident: ref_40
  article-title: Suppressions of Chronic Glomerular Injuries and TGF-Β1 Production by HGF in Attenuation of Murine Diabetic Nephropathy
  publication-title: Am. J. Physiol.-Ren. Physiol.
  doi: 10.1152/ajprenal.00199.2003
– volume: 166
  start-page: 21
  year: 2016
  ident: ref_131
  article-title: EMT: 2016
  publication-title: Cell
  doi: 10.1016/j.cell.2016.06.028
– volume: 40
  start-page: 98
  year: 2019
  ident: ref_147
  article-title: The Mononuclear Phagocyte System: The Relationship between Monocytes and Macrophages
  publication-title: Trends Immunol.
  doi: 10.1016/j.it.2018.11.007
– volume: 14
  start-page: 293
  year: 2015
  ident: ref_69
  article-title: Hepatocyte Growth Factor: A Regulator of Inflammation and Autoimmunity
  publication-title: Autoimmun. Rev.
  doi: 10.1016/j.autrev.2014.11.013
– volume: 21
  start-page: 989
  year: 2015
  ident: ref_130
  article-title: Snail1-Induced Partial Epithelial-to-Mesenchymal Transition Drives Renal Fibrosis in Mice and Can Be Targeted to Reverse Established Disease
  publication-title: Nat. Med.
  doi: 10.1038/nm.3901
– volume: 29
  start-page: 196
  year: 2011
  ident: ref_43
  article-title: TGF-β Signaling in Fibrosis
  publication-title: Growth Factors
  doi: 10.3109/08977194.2011.595714
– volume: 15
  start-page: 178
  year: 2014
  ident: ref_68
  article-title: Molecular Mechanisms of Epithelial–Mesenchymal Transition
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/nrm3758
– ident: ref_10
  doi: 10.1371/journal.pntd.0003899
– volume: 19
  start-page: 1047
  year: 2013
  ident: ref_129
  article-title: Origin and Function of Myofibroblasts in Kidney Fibrosis
  publication-title: Nat. Med.
  doi: 10.1038/nm.3218
– volume: 40
  start-page: 1068
  year: 2008
  ident: ref_57
  article-title: The Role of Proteases in Transforming Growth Factor-β Activation
  publication-title: Int. J. Biochem. Cell Biol.
  doi: 10.1016/j.biocel.2007.11.026
– volume: 44
  start-page: 805
  year: 2020
  ident: ref_11
  article-title: Análise Espacial Da Leptospirose No Brasil
  publication-title: Saúde Em Debate
  doi: 10.1590/0103-1104202012616
– volume: 59
  start-page: 1304
  year: 2001
  ident: ref_38
  article-title: Hepatocyte Growth Factor Suppresses Interstitial Fibrosis in a Mouse Model of Obstructive Nephropathy
  publication-title: Kidney Int.
  doi: 10.1046/j.1523-1755.2001.0590041304.x
– volume: 22
  start-page: 7621
  year: 2018
  ident: ref_39
  article-title: HGF Alleviates Renal Interstitial Fibrosis via Inhibiting the Tgf-Β1/Smad Pathway
  publication-title: Eur. Rev. Med. Pharmacol. Sci.
– volume: 7
  start-page: 65
  year: 2019
  ident: ref_155
  article-title: Murine Models for Leptospirosis Kidney Disease
  publication-title: Transl. Res. Biomed.
  doi: 10.1159/000500388
– volume: 4
  start-page: 95
  year: 2018
  ident: ref_81
  article-title: Canonical Wnt Signaling Promotes Macrophage Proliferation during Kidney Fibrosis
  publication-title: Kidney Dis.
  doi: 10.1159/000488984
– volume: 21
  start-page: 998
  year: 2015
  ident: ref_135
  article-title: Epithelial-to-Mesenchymal Transition Induces Cell Cycle Arrest and Parenchymal Damage in Renal Fibrosis
  publication-title: Nat. Med.
  doi: 10.1038/nm.3902
– volume: 594
  start-page: 2633
  year: 2020
  ident: ref_96
  article-title: Strategies Used by Leptospira Spirochetes to Evade the Host Complement System
  publication-title: FEBS Lett.
  doi: 10.1002/1873-3468.13768
– volume: 11
  start-page: 785
  year: 2010
  ident: ref_101
  article-title: Complement: A Key System for Immune Surveillance and Homeostasis
  publication-title: Nat. Immunol
  doi: 10.1038/ni.1923
– volume: 342
  start-page: 440
  year: 1989
  ident: ref_108
  article-title: Molecular Cloning and Expression of Human Hepatocyte Growth Factor
  publication-title: Nature
  doi: 10.1038/342440a0
– volume: 103
  start-page: 501
  year: 2000
  ident: ref_110
  article-title: InlB-Dependent Internalization of Listeria Is Mediated by the Met Receptor Tyrosine Kinase
  publication-title: Cell
  doi: 10.1016/S0092-8674(00)00141-0
– volume: 302
  start-page: F369
  year: 2012
  ident: ref_136
  article-title: The MiR-200 Family Regulates TGF-Β1-Induced Renal Tubular Epithelial to Mesenchymal Transition through Smad Pathway by Targeting ZEB1 and ZEB2 Expression
  publication-title: Am. J. Physiol.-Ren. Physiol.
  doi: 10.1152/ajprenal.00268.2011
– volume: 10
  start-page: 593
  year: 2008
  ident: ref_137
  article-title: The MiR-200 Family and MiR-205 Regulate Epithelial to Mesenchymal Transition by Targeting ZEB1 and SIP1
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb1722
– volume: 24
  start-page: 8080
  year: 2005
  ident: ref_48
  article-title: The Deubiquitinating Enzyme UCH37 Interacts with Smads and Regulates TGF-β Signalling
  publication-title: Oncogene
  doi: 10.1038/sj.onc.1208944
– volume: 36
  start-page: 188
  year: 2015
  ident: ref_32
  article-title: Artemisinin Analogue SM934 Ameliorates the Proteinuria and Renal Fibrosis in Rat Experimental Membranous Nephropathy
  publication-title: Acta Pharmacol. Sin.
  doi: 10.1038/aps.2014.134
– volume: 8
  start-page: 260
  year: 2020
  ident: ref_58
  article-title: TGF-β-Induced Endothelial to Mesenchymal Transition in Disease and Tissue Engineering
  publication-title: Front. Cell Dev. Biol.
  doi: 10.3389/fcell.2020.00260
– volume: 55
  start-page: 691
  year: 2020
  ident: ref_62
  article-title: Current Perspectives on Inhibitory SMAD7 in Health and Disease
  publication-title: Crit. Rev. Biochem. Mol. Biol.
  doi: 10.1080/10409238.2020.1828260
– volume: 15
  start-page: 2868
  year: 2004
  ident: ref_77
  article-title: Hepatocyte Growth Factor Ameliorates Renal Interstitial Inflammation in Rat Remnant Kidney by Modulating Tubular Expression of Macrophage Chemoattractant Protein-1 and RANTES
  publication-title: J. Am. Soc. Nephrol.
  doi: 10.1097/01.ASN.0000141962.44300.3A
– volume: 27
  start-page: 173
  year: 2009
  ident: ref_117
  article-title: The Antifibrogenic Effect of Hepatocyte Growth Factor (HGF) on Renal Tubular (HK-2) Cells Is Depende
  publication-title: Growth Factors
  doi: 10.1080/08977190902834077
– ident: ref_59
  doi: 10.3389/fphar.2017.00461
– volume: 103
  start-page: 154013
  year: 2020
  ident: ref_21
  article-title: Deletion of Smad3 Prevents Renal Fibrosis and Inflammation in Type 2 Diabetic Nephropathy
  publication-title: Metab. Clin. Exp.
  doi: 10.1016/j.metabol.2019.154013
– volume: 15
  start-page: 297
  year: 2017
  ident: ref_4
  article-title: Virulence of the Zoonotic Agent of Leptospirosis: Still Terra Incognita?
  publication-title: Nat. Rev. Microbiol.
  doi: 10.1038/nrmicro.2017.5
– volume: 4
  start-page: 84
  year: 2014
  ident: ref_30
  article-title: Wnt/β-Catenin Signaling and Kidney Fibrosis
  publication-title: Kidney Int. Suppl.
  doi: 10.1038/kisup.2014.16
– volume: 50
  start-page: 908
  year: 2021
  ident: ref_116
  article-title: Mesenchymal Stem Cells Attenuates TGF-Β1-Induced EMT by Increasing HGF Expression in HK-2 Cells
  publication-title: Iran. J. Public Health
– volume: 32
  start-page: 865
  year: 2000
  ident: ref_121
  article-title: Induction of Cardiac Fibrosis by Aldosterone
  publication-title: J. Mol. Cell. Cardiol.
  doi: 10.1006/jmcc.2000.1129
– volume: 80
  start-page: 1159
  year: 2011
  ident: ref_29
  article-title: Canonical Wnt/Β-Catenin Signaling Mediates Transforming Growth Factor-Β1-Driven Podocyte Injury and Proteinuria
  publication-title: Kidney Int.
  doi: 10.1038/ki.2011.255
– volume: 82
  start-page: 125
  year: 2016
  ident: ref_111
  article-title: The Hepatocyte Growth Factor (HGF)–MET Receptor Tyrosine Kinase Signaling Pathway: Diverse Roles in Modulating Immune Cell Functions
  publication-title: Cytokine
  doi: 10.1016/j.cyto.2015.12.013
– volume: 209
  start-page: 876
  year: 2014
  ident: ref_95
  article-title: Immune Evasion by Pathogenic Leptospira Strains: The Secretion of Proteases That Directly Cleave Complement Proteins
  publication-title: J. Infect. Dis.
  doi: 10.1093/infdis/jit569
– volume: 79
  start-page: 541
  year: 2017
  ident: ref_148
  article-title: Macrophage Polarization
  publication-title: Annu. Rev. Physiol.
  doi: 10.1146/annurev-physiol-022516-034339
– volume: 8
  start-page: 58
  year: 2017
  ident: ref_154
  article-title: Animal Models of Leptospirosis: Of Mice and Hamsters
  publication-title: Front. Immunol.
– volume: 7
  start-page: 8809
  year: 2015
  ident: ref_158
  article-title: TGF-β/Smad3 Signalling Regulates the Transition of Bone Marrow-Derived Macrophages into Myofibroblasts during Tissue Fibrosis
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.6604
– volume: 317
  start-page: F1293
  year: 2019
  ident: ref_92
  article-title: Complement C1r Serine Protease Contributes to Kidney Fibrosis
  publication-title: Am. J. Physiol.-Ren. Physiol.
  doi: 10.1152/ajprenal.00357.2019
– volume: 178
  start-page: 437
  year: 2007
  ident: ref_67
  article-title: Cell Size and Invasion in TGF-β–Induced Epithelial to Mesenchymal Transition Is Regulated by Activation of the MTOR Pathway
  publication-title: J. Cell Biol.
  doi: 10.1083/jcb.200611146
– volume: 25
  start-page: 7469
  year: 2006
  ident: ref_89
  article-title: Function and Biological Roles of the Dickkopf Family of Wnt Modulators
  publication-title: Oncogene
  doi: 10.1038/sj.onc.1210054
– volume: 290
  start-page: 475
  year: 2002
  ident: ref_118
  article-title: Exogenously Administered HGF Activator Augments Liver Regeneration through the Production of Biologically Active HGF
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1006/bbrc.2001.6170
– ident: ref_140
  doi: 10.1371/journal.pone.0013614
– volume: 8
  start-page: 387
  year: 2008
  ident: ref_84
  article-title: Wnt Signalling and Its Impact on Development and Cancer
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/nrc2389
– ident: ref_151
  doi: 10.1371/journal.ppat.1007811
– volume: 115
  start-page: 3977
  year: 2002
  ident: ref_27
  article-title: The Wnt Signalling Pathway
  publication-title: J. Cell Sci.
  doi: 10.1242/jcs.00089
– volume: 312
  start-page: F516
  year: 2017
  ident: ref_104
  article-title: Pericytes and Immune Cells Contribute to Complement Activation in Tubulointerstitial Fibrosis
  publication-title: Am. J. Physiol.-Ren. Physiol.
  doi: 10.1152/ajprenal.00604.2016
– ident: ref_66
  doi: 10.1371/journal.pone.0174471
– volume: 7
  start-page: 44911
  year: 2017
  ident: ref_123
  article-title: Angiotensin II Induces Kidney Inflammatory Injury and Fibrosis through Binding to Myeloid Differentiation Protein-2 (MD2)
  publication-title: Sci. Rep.
  doi: 10.1038/srep44911
– volume: 382
  start-page: 260
  year: 2013
  ident: ref_19
  article-title: Chronic Kidney Disease: Global Dimension and Perspectives
  publication-title: Lancet
  doi: 10.1016/S0140-6736(13)60687-X
– volume: 10
  start-page: 455
  year: 2018
  ident: ref_97
  article-title: Complement and Bacterial Infections: From Molecular Mechanisms to Therapeutic Applications
  publication-title: J. Innate Immun.
  doi: 10.1159/000491439
– volume: 9
  start-page: 411
  year: 2002
  ident: ref_115
  article-title: A Mechanism of Cell Survival: Sequestration of Fas by the HGF Receptor Met
  publication-title: Mol. Cell
  doi: 10.1016/S1097-2765(02)00439-2
– volume: 3
  start-page: a005017
  year: 2011
  ident: ref_55
  article-title: Cross Talk among TGF-β Signaling Pathways, Integrins, and the Extracellular Matrix
  publication-title: Cold Spring Harb. Perspect. Biol.
  doi: 10.1101/cshperspect.a005017
– volume: 114
  start-page: 49
  year: 2019
  ident: ref_99
  article-title: The Hijackers Guide to Escaping Complement: Lessons Learned from Pathogens
  publication-title: Mol. Immunol.
  doi: 10.1016/j.molimm.2019.07.018
– volume: 13
  start-page: 1783
  year: 2011
  ident: ref_144
  article-title: Characteristic Features of Intracellular Pathogenic Leptospira in Infected Murine Macrophages
  publication-title: Cell. Microbiol.
  doi: 10.1111/j.1462-5822.2011.01660.x
– volume: 93
  start-page: 2431
  year: 1994
  ident: ref_126
  article-title: Angiotensin II Stimulates Extracellular Matrix Protein Synthesis through Induction of Transforming Growth Factor-Beta Expression in Rat Glomerular Mesangial Cells
  publication-title: J. Clin. Investig.
  doi: 10.1172/JCI117251
– volume: 283
  start-page: 14910
  year: 2008
  ident: ref_138
  article-title: The MiR-200 Family Inhibits Epithelial-Mesenchymal Transition and Cancer Cell Migration by Direct Targeting of E-Cadherin Transcriptional Repressors ZEB1 and ZEB2
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.C800074200
– volume: 19
  start-page: 47
  year: 2009
  ident: ref_64
  article-title: Ski and SnoN, Potent Negative Regulators of TGF-β Signaling
  publication-title: Cell Res.
  doi: 10.1038/cr.2008.324
– volume: 124
  start-page: 4039
  year: 2011
  ident: ref_31
  article-title: Effect of Anaphylatoxin C3a, C5a on the Tubular Epithelial-Myofibroblast Transdifferentiation in Vitro
  publication-title: Chin. Med. J.
– volume: 25
  start-page: 227
  year: 2011
  ident: ref_53
  article-title: The Role of Intracellular Protein O-Glycosylation in Cell Adhesion and Disease
  publication-title: J. Biomed. Res.
  doi: 10.1016/S1674-8301(11)60031-6
– volume: 2
  start-page: 6
  year: 2011
  ident: ref_5
  article-title: LEPTOSPIRA: Morphology, Classification and Pathogenesis
  publication-title: J Bacteriol. Parasitol.
  doi: 10.4172/2155-9597.1000120
– volume: 18
  start-page: 1
  year: 2018
  ident: ref_145
  article-title: Characterizing Interactions of Leptospira Interrogans with Proximal Renal Tubule Epithelial Cells
  publication-title: BMC Microbiol.
  doi: 10.1186/s12866-018-1206-8
– volume: 8
  start-page: 63
  year: 2018
  ident: ref_94
  article-title: Role of Murine Complement Component C5 in Acute in Vivo Infection by Pathogenic Leptospira Interrogans
  publication-title: Front. Cell. Infect. Microbiol.
  doi: 10.3389/fcimb.2018.00063
– volume: 65
  start-page: 409
  year: 2004
  ident: ref_34
  article-title: Hepatocyte Growth Factor Ameliorates Progression of Interstitial Fibrosis in Rats with Established Renal Injury
  publication-title: Kidney Int.
  doi: 10.1111/j.1523-1755.2004.00417.x
– volume: 10
  start-page: 654
  year: 2008
  ident: ref_49
  article-title: The Type I TGF-β Receptor Is Covalently Modified and Regulated by Sumoylation
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb1728
– volume: 46
  start-page: 792
  year: 2009
  ident: ref_162
  article-title: Review Paper: Host-Pathogen Interactions in the Kidney during Chronic Leptospirosis
  publication-title: Vet. Pathol.
  doi: 10.1354/vp.08-VP-0265-N-REV
– volume: 11
  start-page: 10366
  year: 2014
  ident: ref_14
  article-title: Geographical Scale Effects on the Analysis of Leptospirosis Determinants
  publication-title: Int. J. Environ. Res. Public Health
  doi: 10.3390/ijerph111010366
– volume: 6
  start-page: 262
  year: 2015
  ident: ref_100
  article-title: Complement System Part I €“ Molecular Mechanisms of Activation and Regulation
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2015.00262
– volume: 7
  start-page: 1056
  year: 2011
  ident: ref_44
  article-title: Diverse Roles of TGF-β/Smads in Renal Fibrosis and Inflammation
  publication-title: Int. J. Biol. Sci.
  doi: 10.7150/ijbs.7.1056
– volume: 69
  start-page: 213
  year: 2006
  ident: ref_20
  article-title: Renal Fibrosis: New Insights into the Pathogenesis and Therapeutics
  publication-title: Kidney Int.
  doi: 10.1038/sj.ki.5000054
– volume: 83
  start-page: 4693
  year: 2015
  ident: ref_153
  article-title: Mouse Model for Sublethal Leptospira Interrogans Infection
  publication-title: Infect. Immun.
  doi: 10.1128/IAI.01115-15
– volume: 35
  start-page: 26
  year: 2009
  ident: ref_54
  article-title: TACE-Mediated Ectodomain Shedding of the Type I TGF-β Receptor Downregulates TGF-β Signaling
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2009.06.018
– volume: 15
  start-page: 41
  year: 2000
  ident: ref_80
  article-title: Is the Proximal Tubular Cell a Proinflammatory Cell?
  publication-title: Nephrol. Dial. Transplant.
  doi: 10.1093/ndt/15.suppl_6.41
– volume: 80
  start-page: 524
  year: 2011
  ident: ref_107
  article-title: Distinct Roles for C3a and C5a in Complement-Induced Tubulointerstitial Injury
  publication-title: Kidney Int.
  doi: 10.1038/ki.2011.158
– ident: ref_143
  doi: 10.1371/journal.pntd.0003927
– ident: ref_163
  doi: 10.1371/journal.pntd.0007458
– volume: 183
  start-page: 2669
  year: 2009
  ident: ref_156
  article-title: TLR4- and TLR2-Mediated B Cell Responses Control the Clearance of the Bacterial Pathogen, Leptospira Interrogans
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.0900506
– volume: 278
  start-page: 343
  year: 2003
  ident: ref_114
  article-title: Adenovirus-Mediated Hepatocyte Growth Factor Expression in Mouse Islets Improves Pancreatic Islet Transplant Performance and Reduces Beta Cell Death
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M207848200
– volume: 24
  start-page: 1443
  year: 2009
  ident: ref_63
  article-title: Disruption of the Smad7 Gene Promotes Renal Fibrosis and Inflammation in Unilateral Ureteral Obstruction (UUO) in Mice
  publication-title: Nephrol. Dial. Transplant.
  doi: 10.1093/ndt/gfn699
– volume: 395
  start-page: 709
  year: 2020
  ident: ref_159
  article-title: Global, Regional, and National Burden of Chronic Kidney Disease, 1990–2017: A Systematic Analysis for the Global Burden of Disease Study 2017
  publication-title: Lancet
  doi: 10.1016/S0140-6736(20)30045-3
– volume: 283
  start-page: 7401
  year: 2008
  ident: ref_71
  article-title: Hepatocyte Growth Factor Suppresses Proinflammatory NFκB Activation through GSK3β Inactivation in Renal Tubular Epithelial Cells
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M710396200
– volume: 28
  start-page: 2322
  year: 2017
  ident: ref_87
  article-title: Tubule-Derived Wnts Are Required for Fibroblast Activation and Kidney Fibrosis
  publication-title: J. Am. Soc. Nephrol.
  doi: 10.1681/ASN.2016080902
– volume: 3
  start-page: 757
  year: 2003
  ident: ref_2
  article-title: Leptospirosis: A Zoonotic Disease of Global Importance
  publication-title: Lancet Infect. Dis.
  doi: 10.1016/S1473-3099(03)00830-2
– volume: 320
  start-page: F1001
  year: 2021
  ident: ref_25
  article-title: Transcriptomic Signatures of Exacerbated Progression in Leptospirosis Subclinical Chronic Kidney Disease with Secondary Nephrotoxic Injury
  publication-title: Am. J. Physiol.-Ren. Physiol.
  doi: 10.1152/ajprenal.00640.2020
– volume: 43
  start-page: 1
  year: 2013
  ident: ref_9
  article-title: Diagnosis and Epidemiology of Leptospirosis
  publication-title: Med. Mal. Infect.
  doi: 10.1016/j.medmal.2012.11.005
– volume: 13
  start-page: 1464
  year: 2002
  ident: ref_60
  article-title: Smad7 Inhibits Fibrotic Effect of TGF-β on Renal Tubular Epithelial Cells by Blocking Smad2 Activation
  publication-title: J. Am. Soc. Nephrol.
  doi: 10.1097/01.ASN.0000014252.37680.E4
– volume: 29
  start-page: 182
  year: 2018
  ident: ref_26
  article-title: Wnt/b-Catenin—Promoted Macrophage Alternative Activation Contributes to Kidney Fibrosis
  publication-title: J. Am. Soc. Nephrol.
  doi: 10.1681/ASN.2017040391
– volume: 14
  start-page: 3167
  year: 2003
  ident: ref_65
  article-title: Downregulation of Smad Transcriptional Corepressors SnoN and Ski in the Fibrotic Kidney: An Amplification Mechanism for TGF-Β1 Signaling
  publication-title: J. Am. Soc. Nephrol.
  doi: 10.1097/01.ASN.0000099373.33259.B2
– ident: ref_6
  doi: 10.1371/journal.pntd.0004668
– ident: ref_13
  doi: 10.1371/journal.pntd.0004105
– volume: 62
  start-page: 64
  year: 2019
  ident: ref_164
  article-title: Asymptomatic Leptospiral Infection Is Associated with Canine Chronic Kidney Disease
  publication-title: Comp. Immunol. Microbiol. Infect. Dis.
  doi: 10.1016/j.cimid.2018.11.009
SSID ssj0023259
Score 2.3547475
SecondaryResourceType review_article
Snippet Leptospirosis is a neglected infectious disease caused by pathogenic species of the genus Leptospira. The acute disease is well-described, and, although it...
Leptospirosis is a neglected infectious disease caused by pathogenic species of the genus Leptospira . The acute disease is well-described, and, although it...
SourceID pubmedcentral
proquest
gale
crossref
SourceType Open Access Repository
Aggregation Database
Enrichment Source
Index Database
StartPage 10779
SubjectTerms Bacteria
Communicable diseases
Cytokines
Extracellular matrix
Growth factors
Health aspects
Kidney diseases
Leptospirosis
Ligands
Mutation
Phosphorylation
Proteins
Review
Risk factors
Signal transduction
SummonAdditionalLinks – databaseName: ProQuest Technology Collection
  dbid: 8FG
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1LSwMxEB58IHgRn7i-WEH0YrBNmjR7EhGriHoQC70tSZpiRbfVbQ_-e2d209ot6DmT3ZBk5ptvdx4AJ0ojSKDZZ14qwdC_7TLEeccQnLy26CMoS8nJj0_qrt2478hO-OCWh7DKiU0sDHV34Ogb-QWXGrEQAVRfDj8ZdY2iv6uhhcYiLNcRaSikS7dup4RL8KJZWh0xiCmZqLLGpkCaf9F_-8g5aiuyH4rimsGkecs8Hy05Az-tdVgLfmN8VR70Biz4bBNWyk6S31uQtGeTVGL06uJnTxNaSIcHOCcOGQFxP4sf_HBE7UJwMf18G9qtm5frOxa6IjDXkMmIOdfj3ElfU8YJWTMN1-w1uNMOqZNF98snVpsuNxqxqVY3vKe8bnJnjUKyZ6QVO7CUDTK_CzFHtuAM94kxqMjWJEKbWk8YyxHUhUkiOJ_sS-pCyXDqXPGeInWgbUwr2xjB6VR8WNbK-EvwjDY5JR3C5zkTUgFwVVSNKr1CDkVN0DmP4KAiiXffVYcnx5QG3cvT35sSwfF0mGZSPFnmB-NSRvMm8s0ImpXjna6c6m5XR7L-a1F_W0vyS8Xe_y_fh1VO8S9F4N8BLI2-xv4QHZiRPSpu6Q80ku58
  priority: 102
  providerName: ProQuest
Title Understanding the Renal Fibrotic Process in Leptospirosis
URI https://www.proquest.com/docview/2581020648
https://www.proquest.com/docview/2581827282
https://pubmed.ncbi.nlm.nih.gov/PMC8509513
Volume 22
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3fT9swED4NENJeJhhMZJQqkxC8kFGc2HEeJgSIDiFACFGpb5FtXNGJpUBbCf77fdekhcC2l7z4nFjnH9_3Kec7ok2lARI49iMvVRyB395EwHkXAZy8tuAIyvLl5PMLddJJTruy-5JSqHLg8K_SjutJdR7vvj89PO9jw_9gxQnJvtv_9XsosPOgZNJsjhYASikXMzhPZj8UwBsmddP2AEeRkpkq022-716Dp7eH9NvAyVdI1F6iTxWFDA_KOV-mD774TItlUcnnFco6r--rhCB44ZXnDm0o4wH6hNXlgLBfhGf-fsSVQzCY_nCVOu3j66OTqCqQELlEZqPIuZ4QTvqWMi6WLZO4tJcIpx1UlAUT85nV5kYYDZhq7RnRU16nwlmjoPuMtPEXmi8GhV-jUEA4OCN8Zgz2tDVZrE2rFxsrgO-xyQLamfold1X2cC5icZdDRbAb85obA9qamd-XaTP-ZbjNTs55gvE-Z6pbARgVJ6bKDyCnuB66EAE1apbYBq7ePJ2mfLqKciE1CBRYlw7o26yZe3JoWeEH49JGixTSM6C0Nr2zkXMK7npL0b-dpOLWkilq_PX_H1-nj4JDYSYxgA2aHz2O_Qa4zMg2aS7tpnjq9s8mLRweX1xeNRldZHOyfv8Atsv1tg
linkProvider Scholars Portal
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1LTxsxEB5Rqqq9oD7FFgpbqY9LLZbx2vEeKoSANJTAoSISt63tOGqqdpM2QRV_qr-xM_sIWSR64-zxrjW255tvdx4Ab7QhkCCzL4LSUpB_OxSE814QOAXjyEfQjpOTT890b5B-vlAXK_C3yYXhsMrGJpaGejjx_I18B5UhLCQANXvTX4K7RvHf1aaFRnUsTsLVH6Jss4_Hh7S_bxG7R-cHPVF3FRA-VdlceD9C9Cok2nqpEpv6zihFbzxRD0fuS8icsUO0hmx7smtxpIPpoHdWE1myykl67j24n0pCcs5M735aEDyJZXO2XcI8oVWmq5qeJJjsjL__nCFZB2JbHDW2hIE3keBmdOYS3HUfw1rtp8b71cF6AiuheAoPqs6VV88gGywnxcTkRcZfAk_oEv2e0Jy4zkCIx0XcD9M5tyehxYxnz2FwJ_p6AavFpAjrECOxE28xZNaS4XA2k8YmI2kdkhMhbRbBh0Yvua9LlHOnjB85URVWY95SYwTvFuLTqjbHbYLvWck531l6nrd16gGtiqtf5fvE2bjpOmIEmy1Jumu-PdxsU17f9Vl-fTIjeL0Y5pkcv1aEyWUlY7BD_DaCTmt7FyvnOt_tkWL8raz3bRT7wfLl_1--DQ9756f9vH98drIBj5Bjb8qgw01Ynf--DK_IeZq7rfLExvD1rq_IP6QmK88
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3db9MwED-NTiBeEJ8iY4Mg8fGC1excO87DhAZbtbFRTROV9pbZriOKIO1oJ7R_jb-OuyYpzSR427PtxDr77ne_5D4AXmlDIEFmXwSlpSD_diQI570gcArGkY-gHScnfx7og2Hv05k6W4PfTS4Mh1U2NnFhqEcTz9_Iu6gMYSEBqOkWdVjEyV7__fRCcAcp_tPatNOorshRuPpF9G22c7hHZ_0asb__5eOBqDsMCN9T2Vx4XyB6FRJtvVSJ7fm06KE3nmiII1cmZM7YEVpDdj7ZtljoYFL0zmoiTlY5Sc-9Besps6IOrH_YH5ycLumexEWrtm1CQKFVpqsKn1JmSXf87ccMyVYQ9-IYshVEvI4L12M1V8Cvfx_u1V5rvFtdswewFsqHcLvqY3n1CLLhaopMTD5lfBp4QZ_I-ITWxHU-Qjwu4-MwnXOzEtrMePYYhjcisSfQKSdleAoxElfxFkNmLZkRZzNpbFJI65BcCmmzCN41csl9XbCc-2Z8z4m4sBjzlhgjeLOcPq0qdfxr4lsWcs4aTM_ztk5EoF1xLax8lxgct2BHjGCzNZM0z7eHm2PKa82f5X_vaQQvl8O8kqPZyjC5rOYYTIntRpC2jne5c6763R4px18X1b-NYq9Ybvz_5S_gDqlHfnw4OHoGd5EDcRYRiJvQmf-8DFvkSc3d8_rKxnB-01ryB33zMWE
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Understanding+the+Renal+Fibrotic+Process+in+Leptospirosis&rft.jtitle=International+journal+of+molecular+sciences&rft.au=Luan+Gavi%C3%A3o+Prado&rft.au=Angela+Silva+Barbosa&rft.date=2021-10-01&rft.pub=MDPI+AG&rft.issn=1661-6596&rft.eissn=1422-0067&rft.volume=22&rft.issue=19&rft.spage=10779&rft_id=info:doi/10.3390%2Fijms221910779&rft.externalDBID=HAS_PDF_LINK
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1422-0067&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1422-0067&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1422-0067&client=summon