Macrophage migration inhibitory factor reduces apoptosis in cerebral arteriovenous malformations

• Published in: Neuroscience letters Vol. 508; no. 2; pp. 84 - 88
• Main Authors: Chen, Guangzhong, Zheng, Meng, Shu, Hang, Zhan, Shengquan, Wang, Hongqin, Zhou, Dong, Zeng, Shaojian, Tang, Kai, Feng, Lei
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 06.02.2012
• Subjects: Adult; Apoptosis; Arteriovenous Fistula - enzymology; Arteriovenous Fistula - metabolism; Caspase-3; Cerebral arteriovenous malformation; Female; Humans; Intracranial Arteriovenous Malformations - enzymology; Intracranial Arteriovenous Malformations - metabolism; Intramolecular Oxidoreductases - metabolism; Macrophage migration inhibitory factor; Macrophage Migration-Inhibitory Factors - metabolism; Male; Matrix Metalloproteinase 9 - metabolism; Middle Aged; Young Adult; Macrophage migration inhibitory factor; AVM; MIF; MMP9; Caspase-3; Cerebral arteriovenous malformation; Apoptosis

► We used the human AVM specimens as the research objects. ► We investigated the relationship between MIF, apoptosis and cleaved caspase-3 expression. ► It is the first time to show the abnormal apoptosis may be involved in the pathogenesis of brain AVM. ► The increased MIF expression may play an im...