Vitamin D deficiency is associated with an oxidized plasma cysteine redox potential in critically Ill children

• Published in: The Journal of steroid biochemistry and molecular biology Vol. 175; pp. 164 - 169
• Main Authors: Alvarez, Jessica A., Grunwell, Jocelyn R., Gillespie, Scott E., Tangpricha, Vin, Hebbar, Kiran B.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.01.2018
• Subjects: Adolescent; African Americans; Antimicrobial Cationic Peptides - blood; Antimicrobial Cationic Peptides - immunology; Calcidiol; Cathelicidin; Child; Critical care; Critical Illness; Cross-Sectional Studies; Cysteine - blood; European Continental Ancestry Group; Female; Glutathione - blood; Humans; Immunity, Innate; LL-37; Male; Oxidation-Reduction; Oxidative Stress; Pediatrics; Shock, Septic - blood; Shock, Septic - complications; Shock, Septic - ethnology; Shock, Septic - immunology; Vitamin D - analogs & derivatives; Vitamin D - blood; Vitamin D Deficiency - blood; Vitamin D Deficiency - complications; Vitamin D Deficiency - ethnology; Vitamin D Deficiency - immunology; EhCySS; GSSG; Oxidative stress; Pediatrics; LL-37; Critical care; PELOD; PICU; Cathelicidin; PRISM III; Calcidiol; CySS; 25(OH)D; EhGSSG; Cys; GSH; HPLC

•We examined the link between vitamin D, oxidative stress, and immunity in the PICU.•Vitamin D deficiency was associated with a more oxidized plasma cysteine redox.•Plasma glutathione was higher in vitamin D deficient subjects.•The role of vitamin D in regulating plasma redox in the PICU needs furth...