Pharmacological Effects of Hydrocotyle bonariensis Comm. ex Lam (Araliaceae) Extract on Cardiac Activity
Hydrocotyle bonariensis is one of the medicinal plants used in traditional medicine for the management of hypertension in Africa, Asia, and Latin America. However, the real impact of the traditional use of this plant on arterial hypertension has not yet been the subject of conclusive scientific info...
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Published in | Evidence-based complementary and alternative medicine Vol. 2022; pp. 1 - 9 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
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New York
Hindawi
29.09.2022
Hindawi Limited Hindawi Publishing Corporation |
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Abstract | Hydrocotyle bonariensis is one of the medicinal plants used in traditional medicine for the management of hypertension in Africa, Asia, and Latin America. However, the real impact of the traditional use of this plant on arterial hypertension has not yet been the subject of conclusive scientific information in the literature. This study aimed essentially to evaluate the potential cardiomodulatory effect of the hydroethanolic extract of Hydrocotyle bonariensis. In other to do so, the hydroethanolic extract of H. bonariensis was studied in vivo on the Wistar rat ECG and then in vitro on the isolated perfused Wistar rat heart using the Langendorff system. The extract was also tested on isolated guinea pig atria kept alive in the organ-specific vessel under physiological conditions similar to those of a living organism. At the cellular level, the effects of the extract were evaluated on the human cardiac sodium current INav1.5 and on the human cardiac pacemaker current If. We noted that the extract caused a decrease in P wave and T wave amplitudes and heart rate and an increase in the duration of the RR interval on the in vivo rat ECG. On the isolated perfused Langendorff heart as well as on the isolated atria, a decrease in the RR interval and in the heart rate was noted. The extract had no effect on human cardiac sodium current, but it did reduce human cardiac pacemaker current. In conclusion, the present study demonstrated that Hydrocotyle bonariensis, a medicinal plant traditionally used to prevent and treat hypertension, has an overall cardiomoderating effect. This effect would contribute to the reduction of blood pressure. |
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AbstractList | Hydrocotyle bonariensis is one of the medicinal plants used in traditional medicine for the management of hypertension in Africa, Asia, and Latin America. However, the real impact of the traditional use of this plant on arterial hypertension has not yet been the subject of conclusive scientific information in the literature. This study aimed essentially to evaluate the potential cardiomodulatory effect of the hydroethanolic extract of Hydrocotyle bonariensis. In other to do so, the hydroethanolic extract of H. bonariensis was studied in vivo on the Wistar rat ECG and then in vitro on the isolated perfused Wistar rat heart using the Langendorff system. The extract was also tested on isolated guinea pig atria kept alive in the organ-specific vessel under physiological conditions similar to those of a living organism. At the cellular level, the effects of the extract were evaluated on the human cardiac sodium current INav1.5 and on the human cardiac pacemaker current If. We noted that the extract caused a decrease in P wave and T wave amplitudes and heart rate and an increase in the duration of the RR interval on the in vivo rat ECG. On the isolated perfused Langendorff heart as well as on the isolated atria, a decrease in the RR interval and in the heart rate was noted. The extract had no effect on human cardiac sodium current, but it did reduce human cardiac pacemaker current. In conclusion, the present study demonstrated that Hydrocotyle bonariensis, a medicinal plant traditionally used to prevent and treat hypertension, has an overall cardiomoderating effect. This effect would contribute to the reduction of blood pressure.Hydrocotyle bonariensis is one of the medicinal plants used in traditional medicine for the management of hypertension in Africa, Asia, and Latin America. However, the real impact of the traditional use of this plant on arterial hypertension has not yet been the subject of conclusive scientific information in the literature. This study aimed essentially to evaluate the potential cardiomodulatory effect of the hydroethanolic extract of Hydrocotyle bonariensis. In other to do so, the hydroethanolic extract of H. bonariensis was studied in vivo on the Wistar rat ECG and then in vitro on the isolated perfused Wistar rat heart using the Langendorff system. The extract was also tested on isolated guinea pig atria kept alive in the organ-specific vessel under physiological conditions similar to those of a living organism. At the cellular level, the effects of the extract were evaluated on the human cardiac sodium current INav1.5 and on the human cardiac pacemaker current If. We noted that the extract caused a decrease in P wave and T wave amplitudes and heart rate and an increase in the duration of the RR interval on the in vivo rat ECG. On the isolated perfused Langendorff heart as well as on the isolated atria, a decrease in the RR interval and in the heart rate was noted. The extract had no effect on human cardiac sodium current, but it did reduce human cardiac pacemaker current. In conclusion, the present study demonstrated that Hydrocotyle bonariensis, a medicinal plant traditionally used to prevent and treat hypertension, has an overall cardiomoderating effect. This effect would contribute to the reduction of blood pressure. Hydrocotyle bonariensis is one of the medicinal plants used in traditional medicine for the management of hypertension in Africa, Asia, and Latin America. However, the real impact of the traditional use of this plant on arterial hypertension has not yet been the subject of conclusive scientific information in the literature. This study aimed essentially to evaluate the potential cardiomodulatory effect of the hydroethanolic extract of Hydrocotyle bonariensis. In other to do so, the hydroethanolic extract of H. bonariensis was studied in vivo on the Wistar rat ECG and then in vitro on the isolated perfused Wistar rat heart using the Langendorff system. The extract was also tested on isolated guinea pig atria kept alive in the organ-specific vessel under physiological conditions similar to those of a living organism. At the cellular level, the effects of the extract were evaluated on the human cardiac sodium current INav1.5 and on the human cardiac pacemaker current If. We noted that the extract caused a decrease in P wave and T wave amplitudes and heart rate and an increase in the duration of the RR interval on the in vivo rat ECG. On the isolated perfused Langendorff heart as well as on the isolated atria, a decrease in the RR interval and in the heart rate was noted. The extract had no effect on human cardiac sodium current, but it did reduce human cardiac pacemaker current. In conclusion, the present study demonstrated that Hydrocotyle bonariensis, a medicinal plant traditionally used to prevent and treat hypertension, has an overall cardiomoderating effect. This effect would contribute to the reduction of blood pressure. Hydrocotyle bonariensis is one of the medicinal plants used in traditional medicine for the management of hypertension in Africa, Asia, and Latin America. However, the real impact of the traditional use of this plant on arterial hypertension has not yet been the subject of conclusive scientific information in the literature. This study aimed essentially to evaluate the potential cardiomodulatory effect of the hydroethanolic extract of Hydrocotyle bonariensis . In other to do so, the hydroethanolic extract of H. bonariensis was studied in vivo on the Wistar rat ECG and then in vitro on the isolated perfused Wistar rat heart using the Langendorff system. The extract was also tested on isolated guinea pig atria kept alive in the organ-specific vessel under physiological conditions similar to those of a living organism. At the cellular level, the effects of the extract were evaluated on the human cardiac sodium current INav1.5 and on the human cardiac pacemaker current If. We noted that the extract caused a decrease in P wave and T wave amplitudes and heart rate and an increase in the duration of the RR interval on the in vivo rat ECG. On the isolated perfused Langendorff heart as well as on the isolated atria, a decrease in the RR interval and in the heart rate was noted. The extract had no effect on human cardiac sodium current, but it did reduce human cardiac pacemaker current. In conclusion, the present study demonstrated that Hydrocotyle bonariensis , a medicinal plant traditionally used to prevent and treat hypertension, has an overall cardiomoderating effect. This effect would contribute to the reduction of blood pressure. |
Author | Aklesso, Mouzou Patrick, Bois Tcha, Pakoussi Balakiyém, Kadissoli Aurelien, Chatelier Mindede, Assih Komla, Kaboua |
AuthorAffiliation | 1 Laboratory of Physiology-Pharmacology, FDS, University of Lomé, BP 1515, Lomé, Togo 2 Laboratory of Signaling and Membrane Ion Transport, Pôle Biosanté, University of Poitiers, BP 86000, Poitiers, France |
AuthorAffiliation_xml | – name: 1 Laboratory of Physiology-Pharmacology, FDS, University of Lomé, BP 1515, Lomé, Togo – name: 2 Laboratory of Signaling and Membrane Ion Transport, Pôle Biosanté, University of Poitiers, BP 86000, Poitiers, France |
Author_xml | – sequence: 1 givenname: Kaboua orcidid: 0000-0003-1024-5661 surname: Komla fullname: Komla, Kaboua organization: Laboratory of Physiology-PharmacologyFDSUniversity of LoméBP 1515LoméTogouniv-lome.tg – sequence: 2 givenname: Pakoussi surname: Tcha fullname: Tcha, Pakoussi organization: Laboratory of Physiology-PharmacologyFDSUniversity of LoméBP 1515LoméTogouniv-lome.tg – sequence: 3 givenname: Mouzou surname: Aklesso fullname: Aklesso, Mouzou organization: Laboratory of Physiology-PharmacologyFDSUniversity of LoméBP 1515LoméTogouniv-lome.tg – sequence: 4 givenname: Kadissoli surname: Balakiyém fullname: Balakiyém, Kadissoli organization: Laboratory of Physiology-PharmacologyFDSUniversity of LoméBP 1515LoméTogouniv-lome.tg – sequence: 5 givenname: Assih orcidid: 0000-0001-9611-7649 surname: Mindede fullname: Mindede, Assih organization: Laboratory of Physiology-PharmacologyFDSUniversity of LoméBP 1515LoméTogouniv-lome.tg – sequence: 6 givenname: Bois surname: Patrick fullname: Patrick, Bois organization: Laboratory of Signaling and Membrane Ion TransportPôle BiosantéUniversity of PoitiersBP 86000PoitiersFranceuniv-poitiers.fr – sequence: 7 givenname: Chatelier surname: Aurelien fullname: Aurelien, Chatelier organization: Laboratory of Signaling and Membrane Ion TransportPôle BiosantéUniversity of PoitiersBP 86000PoitiersFranceuniv-poitiers.fr |
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Cites_doi | 10.1016/j.phymed.2005.01.013 10.1016/j.jtcme.2021.09.004 10.1161/CIRCRESAHA.116.303975 10.1186/s43088-021-00160-5 10.1007/s10298-008-0333-z 10.1161/hypertensionaha.107.093336 10.1016/j.ejphar.2014.01.059 10.4314/ijbcs.v6i3.6 10.1093/cvr/cvw009 10.2174/138161207781368729 10.4314/ijbcs.v10i5.9 10.1016/S2214-109X(18)30275-4 10.35759/JABs.155.1 10.1136/adc.82.3.261 10.2174/157489006778777052 |
ContentType | Journal Article |
Copyright | Copyright © 2022 Kaboua Komla et al. Copyright © 2022 Kaboua Komla et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0 Attribution Copyright © 2022 Kaboua Komla et al. 2022 |
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Snippet | Hydrocotyle bonariensis is one of the medicinal plants used in traditional medicine for the management of hypertension in Africa, Asia, and Latin America.... Hydrocotyle bonariensis is one of the medicinal plants used in traditional medicine for the management of hypertension in Africa, Asia, and Latin America.... |
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SubjectTerms | Antihypertensives Blood pressure Cardiac function EKG Electrocardiography Heart Heart rate Hydrocotyle bonariensis Hypertension Laboratory animals Life Sciences Medicinal plants Pacemakers Pharmaceutical sciences Pharmacology Physiology Rodents Sodium Software |
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Title | Pharmacological Effects of Hydrocotyle bonariensis Comm. ex Lam (Araliaceae) Extract on Cardiac Activity |
URI | https://dx.doi.org/10.1155/2022/1961352 https://www.proquest.com/docview/2722976043/abstract/ https://www.proquest.com/docview/2723486968/abstract/ https://hal.science/hal-04314596 https://pubmed.ncbi.nlm.nih.gov/PMC9536924 |
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