An Activated Allele of the c-erbB-2 Oncogene Impairs Kidney and Lung Function and Causes Early Death of Transgenic Mice

• Published in: The Journal of cell biology Vol. 122; no. 1; pp. 199 - 208
• Main Authors: Stöcklin, Elisabeth, Botteri, Florence, Groner, Bernd
• Format: Journal Article
• Language: English
• Published: New York, NY Rockefeller University Press 01.07.1993; The Rockefeller University Press
• Subjects: Alleles; Animals; Biological and medical sciences; Cell physiology; Cellular biology; Death; Epididymis - pathology; Epithelial cells; Female; Fundamental and applied biological sciences. Psychology; Gene Expression Regulation; Genes; Genetic Vectors; Humans; Hyperplasia; Kidney - pathology; Kidneys; Longevity; Lung - pathology; Lungs; Male; Mammary glands; Mammary Glands, Animal - pathology; Mammary Tumor Virus, Mouse - genetics; Mice; Mice, Transgenic; Molecular and cellular biology; Oncogenes; Organ Specificity; Precancerous Conditions - genetics; Precancerous Conditions - pathology; Proto-Oncogene Proteins - biosynthesis; Proto-Oncogene Proteins - genetics; Proto-Oncogenes; Receptor, ErbB-2; Receptors; Receptors, Cell Surface - biosynthesis; Receptors, Cell Surface - genetics; Repetitive Sequences, Nucleic Acid; Responses to growth factors, tumor promotors, other factors; Rodents; Transgenes; Transgenic animals; Tumors; Vertebrata; Mammalia; Urinary system; Mouse; Hyperplasia; Lung; Rodentia; Transgenic animal; Mammary gland; Gene expression; Respiratory system; Kidney

The pathogenicity of the human c-erbB-2 oncogene was evaluated in transgenic mice. A DNA sequence comprising the promoter-enhancer region of the MMTV LTR and a constitutively activated allele of the human c-erbB-2 growth factor receptor gene was introduced into the germ line of mice. Expression of t...