Recurrent Hemorrhagic Venous Infarctions Caused by Thrombosis of a Pontine Developmental Venous Anomaly and Protein S Mutation

• Published in: Journal of stroke and cerebrovascular diseases Vol. 25; no. 11; pp. e216 - e217
• Main Authors: Nakamura, Yuri, MD, Takase, Kei-ichiro, MD, PhD, Matsushita, Takuya, MD, PhD, Yoshimura, Satoshi, MD, PhD, Yamasaki, Ryo, MD, PhD, Murai, Hiroyuki, MD, PhD, Kikuchi, Kazufumi, MD, PhD, Kira, Jun-ichi, MD, PhD
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.2016
• Subjects: Adult; Anticoagulants - therapeutic use; Blood Coagulation - genetics; Blood Coagulation Tests; Brain Infarction - diagnostic imaging; Brain Infarction - etiology; Cardiovascular; Central Nervous System Vascular Malformations - complications; Central Nervous System Vascular Malformations - diagnostic imaging; Cerebral Angiography - methods; Cerebral Veins - abnormalities; Cerebral Veins - diagnostic imaging; developmental venous anomaly; DNA Mutational Analysis; hemorrhagic cerebral venous infarction; Homozygote; Humans; Intracranial Hemorrhages - diagnostic imaging; Intracranial Hemorrhages - etiology; Intracranial Thrombosis - diagnostic imaging; Intracranial Thrombosis - drug therapy; Intracranial Thrombosis - etiology; Magnetic Resonance Angiography; Magnetic Resonance Imaging; Male; Mutation; Neurology; Pons - blood supply; Protein S - genetics; protein S deficiency; Protein S Deficiency - blood; Protein S Deficiency - complications; Protein S Deficiency - diagnosis; Protein S Deficiency - drug therapy; Protein S Deficiency - genetics; protein S Tokushima; Recurrence; Recurrent cerebral venous infarction; Treatment Outcome; Venous Thrombosis - diagnostic imaging; Venous Thrombosis - drug therapy; Venous Thrombosis - etiology; Warfarin - therapeutic use; Recurrent cerebral venous infarction; protein S deficiency; hemorrhagic cerebral venous infarction; protein S Tokushima; developmental venous anomaly

A 34-year-old man presented with an acute onset of upbeat nystagmus, slurred speech, and limb and truncal ataxias. The patient had a history of limb ataxia and gait disturbance previously treated as brainstem encephalitis with corticosteroids 3 years previously. Brain magnetic resonance imaging show...