NtMYB4 and NtCHS1 Are Critical Factors in the Regulation of Flavonoid Biosynthesis and Are Involved in Salinity Responsiveness
High levels of salinity induce serious oxidative damage in plants. Flavonoids, as antioxidants, have important roles in reactive oxygen species (ROS) scavenging. In the present study, the tobacco R2R3 MYB type repressor, NtMYB4, was isolated and characterized. The expression of was suppressed by sal...
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| Published in | Frontiers in plant science Vol. 10; p. 178 |
|---|---|
| Main Authors | , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
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Frontiers Media S.A
21.02.2019
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| Abstract | High levels of salinity induce serious oxidative damage in plants. Flavonoids, as antioxidants, have important roles in reactive oxygen species (ROS) scavenging. In the present study, the tobacco R2R3 MYB type repressor, NtMYB4, was isolated and characterized. The expression of
was suppressed by salinity. Overexpression of
reduced the salt tolerance in transgenic tobacco plants. NtMYB4 repressed the promoter activity of
and negatively regulated its expression. Rutin accumulation was significantly decreased in
overexpressing transgenic plants and
RNAi silenced transgenic plants. Moreover, high H
O
and
contents were detected in both types of rutin-reduced transgenic plants under high salt stress. In addition, exogenous rutin supplementation effectively scavenged ROS (H
O
and
) and improved the salt tolerance of the rutin-reduced transgenic plants. In contrast,
overexpressing plants had increased rutin accumulation, lower H
O
and
contents, and higher tolerance to salinity. These results suggested that tobacco NtMYB4 acts as a salinity response repressor and negatively regulates
expression, which results in the reduced flavonoid accumulation and weakened ROS-scavenging ability under salt stress. |
|---|---|
| AbstractList | High levels of salinity induce serious oxidative damage in plants. Flavonoids, as antioxidants, have important roles in reactive oxygen species (ROS) scavenging. In the present study, the tobacco R2R3 MYB type repressor, NtMYB4, was isolated and characterized. The expression of NtMYB4 was suppressed by salinity. Overexpression of NtMYB4 reduced the salt tolerance in transgenic tobacco plants. NtMYB4 repressed the promoter activity of NtCHS1 and negatively regulated its expression. Rutin accumulation was significantly decreased in NtMYB4 overexpressing transgenic plants and NtCHS1 RNAi silenced transgenic plants. Moreover, high H2O2 and O 2 - contents were detected in both types of rutin-reduced transgenic plants under high salt stress. In addition, exogenous rutin supplementation effectively scavenged ROS (H2O2 and O 2 - ) and improved the salt tolerance of the rutin-reduced transgenic plants. In contrast, NtCHS1 overexpressing plants had increased rutin accumulation, lower H2O2 and O 2 - contents, and higher tolerance to salinity. These results suggested that tobacco NtMYB4 acts as a salinity response repressor and negatively regulates NtCHS1 expression, which results in the reduced flavonoid accumulation and weakened ROS-scavenging ability under salt stress.High levels of salinity induce serious oxidative damage in plants. Flavonoids, as antioxidants, have important roles in reactive oxygen species (ROS) scavenging. In the present study, the tobacco R2R3 MYB type repressor, NtMYB4, was isolated and characterized. The expression of NtMYB4 was suppressed by salinity. Overexpression of NtMYB4 reduced the salt tolerance in transgenic tobacco plants. NtMYB4 repressed the promoter activity of NtCHS1 and negatively regulated its expression. Rutin accumulation was significantly decreased in NtMYB4 overexpressing transgenic plants and NtCHS1 RNAi silenced transgenic plants. Moreover, high H2O2 and O 2 - contents were detected in both types of rutin-reduced transgenic plants under high salt stress. In addition, exogenous rutin supplementation effectively scavenged ROS (H2O2 and O 2 - ) and improved the salt tolerance of the rutin-reduced transgenic plants. In contrast, NtCHS1 overexpressing plants had increased rutin accumulation, lower H2O2 and O 2 - contents, and higher tolerance to salinity. These results suggested that tobacco NtMYB4 acts as a salinity response repressor and negatively regulates NtCHS1 expression, which results in the reduced flavonoid accumulation and weakened ROS-scavenging ability under salt stress. High levels of salinity induce serious oxidative damage in plants. Flavonoids, as antioxidants, have important roles in reactive oxygen species (ROS) scavenging. In the present study, the tobacco R2R3 MYB type repressor, NtMYB4, was isolated and characterized. The expression of NtMYB4 was suppressed by salinity. Overexpression of NtMYB4 reduced the salt tolerance in transgenic tobacco plants. NtMYB4 repressed the promoter activity of NtCHS1 and negatively regulated its expression. Rutin accumulation was significantly decreased in NtMYB4 overexpressing transgenic plants and NtCHS1 RNAi silenced transgenic plants. Moreover, high H2O2 and O2− contents were detected in both types of rutin-reduced transgenic plants under high salt stress. In addition, exogenous rutin supplementation effectively scavenged ROS (H2O2 and O2−) and improved the salt tolerance of the rutin-reduced transgenic plants. In contrast, NtCHS1 overexpressing plants had increased rutin accumulation, lower H2O2 and O2− contents, and higher tolerance to salinity. These results suggested that tobacco NtMYB4 acts as a salinity response repressor and negatively regulates NtCHS1 expression, which results in the reduced flavonoid accumulation and weakened ROS-scavenging ability under salt stress. High levels of salinity induce serious oxidative damage in plants. Flavonoids, as antioxidants, have important roles in reactive oxygen species (ROS) scavenging. In the present study, the tobacco R2R3 MYB type repressor, NtMYB4, was isolated and characterized. The expression of NtMYB4 was suppressed by salinity. Overexpression of NtMYB4 reduced the salt tolerance in transgenic tobacco plants. NtMYB4 repressed the promoter activity of NtCHS1 and negatively regulated its expression. Rutin accumulation was significantly decreased in NtMYB4 overexpressing transgenic plants and NtCHS1 RNAi silenced transgenic plants. Moreover, high H 2 O 2 and O 2 − contents were detected in both types of rutin-reduced transgenic plants under high salt stress. In addition, exogenous rutin supplementation effectively scavenged ROS (H 2 O 2 and O 2 − ) and improved the salt tolerance of the rutin-reduced transgenic plants. In contrast, NtCHS1 overexpressing plants had increased rutin accumulation, lower H 2 O 2 and O 2 − contents, and higher tolerance to salinity. These results suggested that tobacco NtMYB4 acts as a salinity response repressor and negatively regulates NtCHS1 expression, which results in the reduced flavonoid accumulation and weakened ROS-scavenging ability under salt stress. High levels of salinity induce serious oxidative damage in plants. Flavonoids, as antioxidants, have important roles in reactive oxygen species (ROS) scavenging. In the present study, the tobacco R2R3 MYB type repressor, NtMYB4, was isolated and characterized. The expression of was suppressed by salinity. Overexpression of reduced the salt tolerance in transgenic tobacco plants. NtMYB4 repressed the promoter activity of and negatively regulated its expression. Rutin accumulation was significantly decreased in overexpressing transgenic plants and RNAi silenced transgenic plants. Moreover, high H O and contents were detected in both types of rutin-reduced transgenic plants under high salt stress. In addition, exogenous rutin supplementation effectively scavenged ROS (H O and ) and improved the salt tolerance of the rutin-reduced transgenic plants. In contrast, overexpressing plants had increased rutin accumulation, lower H O and contents, and higher tolerance to salinity. These results suggested that tobacco NtMYB4 acts as a salinity response repressor and negatively regulates expression, which results in the reduced flavonoid accumulation and weakened ROS-scavenging ability under salt stress. |
| Author | Wang, Yuanying Wu, Fengyan Qian, Yanli Pan, Xuhao Wu, Zhenying Fu, Chunxiang Chen, Shuai Li, Yiting Lin, Hao Yang, Aiguo Li, Fengxia |
| AuthorAffiliation | 2 Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences , Qingdao , China 1 Tobacco Research Institute, Chinese Academy of Agricultural Sciences , Qingdao , China 3 Biotechnology Research Institute, Chinese Academy of Agricultural Sciences , Beijing , China |
| AuthorAffiliation_xml | – name: 2 Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences , Qingdao , China – name: 1 Tobacco Research Institute, Chinese Academy of Agricultural Sciences , Qingdao , China – name: 3 Biotechnology Research Institute, Chinese Academy of Agricultural Sciences , Beijing , China |
| Author_xml | – sequence: 1 givenname: Shuai surname: Chen fullname: Chen, Shuai – sequence: 2 givenname: Fengyan surname: Wu fullname: Wu, Fengyan – sequence: 3 givenname: Yiting surname: Li fullname: Li, Yiting – sequence: 4 givenname: Yanli surname: Qian fullname: Qian, Yanli – sequence: 5 givenname: Xuhao surname: Pan fullname: Pan, Xuhao – sequence: 6 givenname: Fengxia surname: Li fullname: Li, Fengxia – sequence: 7 givenname: Yuanying surname: Wang fullname: Wang, Yuanying – sequence: 8 givenname: Zhenying surname: Wu fullname: Wu, Zhenying – sequence: 9 givenname: Chunxiang surname: Fu fullname: Fu, Chunxiang – sequence: 10 givenname: Hao surname: Lin fullname: Lin, Hao – sequence: 11 givenname: Aiguo surname: Yang fullname: Yang, Aiguo |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30846995$$D View this record in MEDLINE/PubMed |
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| Copyright | Copyright © 2019 Chen, Wu, Li, Qian, Pan, Li, Wang, Wu, Fu, Lin and Yang. 2019 Chen, Wu, Li, Qian, Pan, Li, Wang, Wu, Fu, Lin and Yang |
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| Keywords | ROS level flavonoid pathway salt stress NtMYB4 NtCHS1 |
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| Title | NtMYB4 and NtCHS1 Are Critical Factors in the Regulation of Flavonoid Biosynthesis and Are Involved in Salinity Responsiveness |
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