Inverse modeling framework for characterizing patient-specific microstructural changes in the pulmonary arteries

• Published in: Journal of the mechanical behavior of biomedical materials Vol. 119; p. 104448
• Main Authors: Pourmodheji, Reza, Jiang, Zhenxiang, Tossas-Betancourt, Christopher, Figueroa, C. Alberto, Baek, Seungik, Lee, Lik-Chuan
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.07.2021
• Subjects: Child; Elastin; Humans; Inverse finite element; Lung; Myocytes, Smooth Muscle; Pulmonary arterial hypertension; Pulmonary Artery - diagnostic imaging; Pulmonary vascular stiffness; Vascular remodeling; Vascular remodeling; Inverse finite element; Pulmonary arterial hypertension; Pulmonary vascular stiffness

Microstructural changes in the pulmonary arteries associated with pulmonary arterial hypertension (PAH) is not well understood and characterized in humans. To address this issue, we developed and applied a patient-specific inverse finite element (FE) modeling framework to characterize mechanical and...