6 Iodo-δ-lactone: A derivative of arachidonic acid with antitumor effects in HT-29 colon cancer cells

• Published in: Prostaglandins, leukotrienes and essential fatty acids Vol. 88; no. 4; pp. 273 - 280
• Main Authors: Thomasz, Lisa, Oglio, Romina, Rossich, Luciano, Villamar, Sonia, Perona, Marina, Salvarredi, Leonardo, Dagrosa, Alejandra, Pisarev, Mario A, Juvenal, Guillermo J
• Format: Journal Article
• Language: English
• Published: Scotland Elsevier Ltd 01.04.2013
• Subjects: Advanced Basic Science; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Apoptosis - drug effects; Arachidonic acid; Arachidonic Acid - chemistry; Arachidonic Acids - chemistry; Arachidonic Acids - pharmacology; Cell Proliferation - drug effects; Colon cancer; Endocrinology & Metabolism; HT29 Cells; Humans; Iodolactone; Iodolipids; Thyroid; Iodolipids; Iodolactone; Colon cancer; Arachidonic acid; Thyroid

Abstract Background IL-δ (5-hydroxy-6 iodo-8,11,14-eicosatrienoic delta lactone) an iodinated arachidonic acid (AA) derivative, is one of the iodolipids biosynthesized by the thyroid. Although IL-δ regulates several thyroid parameters such as cell proliferation and goiter growth it was found that th...