Influences of age and gender on results of noninvasive brachial–ankle pulse wave velocity measurement—a survey of 12 517 subjects
The present study was conducted to evaluate the influences of age and gender on the results of noninvasive brachial–ankle pulse wave velocity (baPWV). In 12 517 subjects who had no medication and no history of cardiovascular diseases, multiple regression analysis demonstrated that age, blood pressur...
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| Published in | Atherosclerosis Vol. 166; no. 2; pp. 303 - 309 |
|---|---|
| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Amsterdam
Elsevier Ireland Ltd
01.02.2003
Elsevier |
| Subjects | |
| Online Access | Get full text |
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| Abstract | The present study was conducted to evaluate the influences of age and gender on the results of noninvasive brachial–ankle pulse wave velocity (baPWV). In 12 517 subjects who had no medication and no history of cardiovascular diseases, multiple regression analysis demonstrated that age, blood pressure, body mass index, triglycerides, blood glucose, and uric acid were significant variables for baPWV in both genders. From this population, we extracted 7881 ‘healthy subjects’ (4488 males and 3393 females, 25–87 years) without any of the atherogenic risk factors, and the results of baPWV were analyzed chronologically in 5-year age intervals. baPWV was lower in females than in males until age 60, and became similar in both genders over age 60. Multiple regression analysis demonstrated that not only the value of
R
2 but also the coefficient of the effect of age on baPWV are larger in females than in males. In the estimation of the regression curve, the relationship between age and baPWV demonstrated a quadratic curve in both genders. Thus, aging influences baPWV, and its effect is more prominent in female. Menopause seems to be the crucial phenomenon to explain the augmented increase in arterial stiffness with aging in females. |
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| AbstractList | The present study was conducted to evaluate the influences of age and gender on the results of noninvasive brachial–ankle pulse wave velocity (baPWV). In 12 517 subjects who had no medication and no history of cardiovascular diseases, multiple regression analysis demonstrated that age, blood pressure, body mass index, triglycerides, blood glucose, and uric acid were significant variables for baPWV in both genders. From this population, we extracted 7881 ‘healthy subjects’ (4488 males and 3393 females, 25–87 years) without any of the atherogenic risk factors, and the results of baPWV were analyzed chronologically in 5-year age intervals. baPWV was lower in females than in males until age 60, and became similar in both genders over age 60. Multiple regression analysis demonstrated that not only the value of
R
2 but also the coefficient of the effect of age on baPWV are larger in females than in males. In the estimation of the regression curve, the relationship between age and baPWV demonstrated a quadratic curve in both genders. Thus, aging influences baPWV, and its effect is more prominent in female. Menopause seems to be the crucial phenomenon to explain the augmented increase in arterial stiffness with aging in females. |
| Author | Chikamori, Taishiro Yamamoto, Yoshio Doba, Nobutaka Koji, Yutaka Tomiyama, Hirofumi Arai, Tomio Hirose, Kenichi Hinohara, Shigeaki Yamashina, Akira Hori, Saburoh |
| Author_xml | – sequence: 1 givenname: Hirofumi surname: Tomiyama fullname: Tomiyama, Hirofumi organization: The Second Department of Internal Medicine, Tokyo Medical University, 6-7-1, Nishi-shinjuku, Shinjuku-ku, Tokyo 160-0023, Japan – sequence: 2 givenname: Akira surname: Yamashina fullname: Yamashina, Akira email: akyam@tokyo-med.ac.jp organization: The Second Department of Internal Medicine, Tokyo Medical University, 6-7-1, Nishi-shinjuku, Shinjuku-ku, Tokyo 160-0023, Japan – sequence: 3 givenname: Tomio surname: Arai fullname: Arai, Tomio organization: The Second Department of Internal Medicine, Tokyo Medical University, 6-7-1, Nishi-shinjuku, Shinjuku-ku, Tokyo 160-0023, Japan – sequence: 4 givenname: Kenichi surname: Hirose fullname: Hirose, Kenichi organization: The Second Department of Internal Medicine, Tokyo Medical University, 6-7-1, Nishi-shinjuku, Shinjuku-ku, Tokyo 160-0023, Japan – sequence: 5 givenname: Yutaka surname: Koji fullname: Koji, Yutaka organization: The Second Department of Internal Medicine, Tokyo Medical University, 6-7-1, Nishi-shinjuku, Shinjuku-ku, Tokyo 160-0023, Japan – sequence: 6 givenname: Taishiro surname: Chikamori fullname: Chikamori, Taishiro organization: The Second Department of Internal Medicine, Tokyo Medical University, 6-7-1, Nishi-shinjuku, Shinjuku-ku, Tokyo 160-0023, Japan – sequence: 7 givenname: Saburoh surname: Hori fullname: Hori, Saburoh organization: The Preventive Medical Center, St. Luke's International Hospital, Tokyo, Japan – sequence: 8 givenname: Yoshio surname: Yamamoto fullname: Yamamoto, Yoshio organization: The Health Care Center, Kajima Corporation, Tokyo, Japan – sequence: 9 givenname: Nobutaka surname: Doba fullname: Doba, Nobutaka organization: The Life Planning Center, Tokyo, Japan – sequence: 10 givenname: Shigeaki surname: Hinohara fullname: Hinohara, Shigeaki organization: The Life Planning Center, Tokyo, Japan |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14472241$$DView record in Pascal Francis |
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| Snippet | The present study was conducted to evaluate the influences of age and gender on the results of noninvasive brachial–ankle pulse wave velocity (baPWV). In 12... |
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| SubjectTerms | Age Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Gender Medical sciences Pulse pressure Pulse wave velocity |
| Title | Influences of age and gender on results of noninvasive brachial–ankle pulse wave velocity measurement—a survey of 12 517 subjects |
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