In-depth Site-specific Analysis of N-glycoproteome in Human Cerebrospinal Fluid and Glycosylation Landscape Changes in Alzheimer's Disease
As the body fluid that directly interchanges with the extracellular fluid of the central nervous system (CNS), cerebrospinal fluid (CSF) serves as a rich source for CNS-related disease biomarker discovery. Extensive proteome profiling has been conducted for CSF, but studies aimed at unraveling site-...
Saved in:
| Published in | Molecular & cellular proteomics Vol. 20; p. 100081 |
|---|---|
| Main Authors | , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
01.01.2021
American Society for Biochemistry and Molecular Biology |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | As the body fluid that directly interchanges with the extracellular fluid of the central nervous system (CNS), cerebrospinal fluid (CSF) serves as a rich source for CNS-related disease biomarker discovery. Extensive proteome profiling has been conducted for CSF, but studies aimed at unraveling site-specific CSF N-glycoproteome are lacking. Initial efforts into site-specific N-glycoproteomics study in CSF yield limited coverage, hindering further experimental design of glycosylation-based disease biomarker discovery in CSF. In the present study, we have developed an N-glycoproteomic approach that combines enhanced N-glycopeptide sequential enrichment by hydrophilic interaction chromatography (HILIC) and boronic acid enrichment with electron transfer and higher-energy collision dissociation (EThcD) for large-scale intact N-glycopeptide analysis. The application of the developed approach to the analyses of human CSF samples enabled identifications of a total of 2893 intact N-glycopeptides from 511 N-glycosites and 285 N-glycoproteins. To our knowledge, this is the largest site-specific N-glycoproteome dataset reported for CSF to date. Such dataset provides molecular basis for a better understanding of the structure–function relationships of glycoproteins and their roles in CNS-related physiological and pathological processes. As accumulating evidence suggests that defects in glycosylation are involved in Alzheimer's disease (AD) pathogenesis, in the present study, a comparative in-depth N-glycoproteomic analysis was conducted for CSF samples from healthy control and AD patients, which yielded a comparable N-glycoproteome coverage but a distinct expression pattern for different categories of glycoforms, such as decreased fucosylation in AD CSF samples. Altered glycosylation patterns were detected for a number of N-glycoproteins including alpha-1-antichymotrypsin, ephrin-A3 and carnosinase CN1 etc., which serve as potentially interesting targets for further glycosylation-based AD study and may eventually lead to molecular elucidation of the role of glycosylation in AD progression.
[Display omitted]
•Efficient N-glycopeptide sequential enrichment by HILIC and boronic acid enrichment.•Site-specific intact N-glycopeptide characterization using EThcD.•In-depth site-specific N-glycoproteome analysis in human CSF.•Mapping the landscape of glycosylation patterns in Alzheimer's disease.
An exploratory glycosylation-based biomarker study has been conducted for in-depth mapping of an overall glycosylation landscape and site-specific alteration in glycoproteome collected from cerebrospinal fluids (CSF) in healthy control and Alzheimer’s disease (AD) subjects. The comparison will shed light on the glycoproteome profile, dominant glycosylation differences and similarities, and some of the interesting glycoprotein candidates with specific glycosylation pattern alterations in AD. |
|---|---|
| AbstractList | As the body fluid that directly interchanges with the extracellular fluid of the central nervous system (CNS), cerebrospinal fluid (CSF) serves as a rich source for CNS-related disease biomarker discovery. Extensive proteome profiling has been conducted for CSF, but studies aimed at unraveling site-specific CSF N-glycoproteome are lacking. Initial efforts into site-specific N-glycoproteomics study in CSF yield limited coverage, hindering further experimental design of glycosylation-based disease biomarker discovery in CSF. In the present study, we have developed an N-glycoproteomic approach that combines enhanced N-glycopeptide sequential enrichment by hydrophilic interaction chromatography (HILIC) and boronic acid enrichment with electron transfer and higher-energy collision dissociation (EThcD) for large-scale intact N-glycopeptide analysis. The application of the developed approach to the analyses of human CSF samples enabled identifications of a total of 2893 intact N-glycopeptides from 511 N-glycosites and 285 N-glycoproteins. To our knowledge, this is the largest site-specific N-glycoproteome dataset reported for CSF to date. Such dataset provides molecular basis for a better understanding of the structure–function relationships of glycoproteins and their roles in CNS-related physiological and pathological processes. As accumulating evidence suggests that defects in glycosylation are involved in Alzheimer's disease (AD) pathogenesis, in the present study, a comparative in-depth N-glycoproteomic analysis was conducted for CSF samples from healthy control and AD patients, which yielded a comparable N-glycoproteome coverage but a distinct expression pattern for different categories of glycoforms, such as decreased fucosylation in AD CSF samples. Altered glycosylation patterns were detected for a number of N-glycoproteins including alpha-1-antichymotrypsin, ephrin-A3 and carnosinase CN1 etc., which serve as potentially interesting targets for further glycosylation-based AD study and may eventually lead to molecular elucidation of the role of glycosylation in AD progression.
•
Efficient N-glycopeptide sequential enrichment by HILIC and boronic acid enrichment.
•
Site-specific intact N-glycopeptide characterization using EThcD.
•
In-depth site-specific N-glycoproteome analysis in human CSF.
•
Mapping the landscape of glycosylation patterns in Alzheimer's disease.
An exploratory glycosylation-based biomarker study has been conducted for in-depth mapping of an overall glycosylation landscape and site-specific alteration in glycoproteome collected from cerebrospinal fluids (CSF) in healthy control and Alzheimer’s disease (AD) subjects. The comparison will shed light on the glycoproteome profile, dominant glycosylation differences and similarities, and some of the interesting glycoprotein candidates with specific glycosylation pattern alterations in AD. As the body fluid that directly interchanges with the extracellular fluid of the central nervous system (CNS), cerebrospinal fluid (CSF) serves as a rich source for CNS-related disease biomarker discovery. Extensive proteome profiling has been conducted for CSF, but studies aimed at unraveling site-specific CSF N-glycoproteome are lacking. Initial efforts into site-specific N-glycoproteomics study in CSF yield limited coverage, hindering further experimental design of glycosylation-based disease biomarker discovery in CSF. In the present study, we have developed an N-glycoproteomic approach that combines enhanced N-glycopeptide sequential enrichment by hydrophilic interaction chromatography (HILIC) and boronic acid enrichment with electron transfer and higher-energy collision dissociation (EThcD) for large-scale intact N-glycopeptide analysis. The application of the developed approach to the analyses of human CSF samples enabled identifications of a total of 2893 intact N-glycopeptides from 511 N-glycosites and 285 N-glycoproteins. To our knowledge, this is the largest site-specific N-glycoproteome dataset reported for CSF to date. Such dataset provides molecular basis for a better understanding of the structure-function relationships of glycoproteins and their roles in CNS-related physiological and pathological processes. As accumulating evidence suggests that defects in glycosylation are involved in Alzheimer's disease (AD) pathogenesis, in the present study, a comparative in-depth N-glycoproteomic analysis was conducted for CSF samples from healthy control and AD patients, which yielded a comparable N-glycoproteome coverage but a distinct expression pattern for different categories of glycoforms, such as decreased fucosylation in AD CSF samples. Altered glycosylation patterns were detected for a number of N-glycoproteins including alpha-1-antichymotrypsin, ephrin-A3 and carnosinase CN1 etc., which serve as potentially interesting targets for further glycosylation-based AD study and may eventually lead to molecular elucidation of the role of glycosylation in AD progression.As the body fluid that directly interchanges with the extracellular fluid of the central nervous system (CNS), cerebrospinal fluid (CSF) serves as a rich source for CNS-related disease biomarker discovery. Extensive proteome profiling has been conducted for CSF, but studies aimed at unraveling site-specific CSF N-glycoproteome are lacking. Initial efforts into site-specific N-glycoproteomics study in CSF yield limited coverage, hindering further experimental design of glycosylation-based disease biomarker discovery in CSF. In the present study, we have developed an N-glycoproteomic approach that combines enhanced N-glycopeptide sequential enrichment by hydrophilic interaction chromatography (HILIC) and boronic acid enrichment with electron transfer and higher-energy collision dissociation (EThcD) for large-scale intact N-glycopeptide analysis. The application of the developed approach to the analyses of human CSF samples enabled identifications of a total of 2893 intact N-glycopeptides from 511 N-glycosites and 285 N-glycoproteins. To our knowledge, this is the largest site-specific N-glycoproteome dataset reported for CSF to date. Such dataset provides molecular basis for a better understanding of the structure-function relationships of glycoproteins and their roles in CNS-related physiological and pathological processes. As accumulating evidence suggests that defects in glycosylation are involved in Alzheimer's disease (AD) pathogenesis, in the present study, a comparative in-depth N-glycoproteomic analysis was conducted for CSF samples from healthy control and AD patients, which yielded a comparable N-glycoproteome coverage but a distinct expression pattern for different categories of glycoforms, such as decreased fucosylation in AD CSF samples. Altered glycosylation patterns were detected for a number of N-glycoproteins including alpha-1-antichymotrypsin, ephrin-A3 and carnosinase CN1 etc., which serve as potentially interesting targets for further glycosylation-based AD study and may eventually lead to molecular elucidation of the role of glycosylation in AD progression. As the body fluid that directly interchanges with the extracellular fluid of the central nervous system (CNS), cerebrospinal fluid (CSF) serves as a rich source for CNS-related disease biomarker discovery. Extensive proteome profiling has been conducted for CSF, but studies aimed at unraveling site-specific CSF N-glycoproteome are lacking. Initial efforts into site-specific N-glycoproteomics study in CSF yield limited coverage, hindering further experimental design of glycosylation-based disease biomarker discovery in CSF. In the present study, we have developed an N-glycoproteomic approach that combines enhanced N-glycopeptide sequential enrichment by hydrophilic interaction chromatography (HILIC) and boronic acid enrichment with electron transfer and higher-energy collision dissociation (EThcD) for large-scale intact N-glycopeptide analysis. The application of the developed approach to the analyses of human CSF samples enabled identifications of a total of 2893 intact N-glycopeptides from 511 N-glycosites and 285 N-glycoproteins. To our knowledge, this is the largest site-specific N-glycoproteome dataset reported for CSF to date. Such dataset provides molecular basis for a better understanding of the structure-function relationships of glycoproteins and their roles in CNS-related physiological and pathological processes. As accumulating evidence suggests that defects in glycosylation are involved in Alzheimer's disease (AD) pathogenesis, in the present study, a comparative in-depth N-glycoproteomic analysis was conducted for CSF samples from healthy control and AD patients, which yielded a comparable N-glycoproteome coverage but a distinct expression pattern for different categories of glycoforms, such as decreased fucosylation in AD CSF samples. Altered glycosylation patterns were detected for a number of N-glycoproteins including alpha-1-antichymotrypsin, ephrin-A3 and carnosinase CN1 etc., which serve as potentially interesting targets for further glycosylation-based AD study and may eventually lead to molecular elucidation of the role of glycosylation in AD progression. As the body fluid that directly interchanges with the extracellular fluid of the central nervous system (CNS), cerebrospinal fluid (CSF) serves as a rich source for CNS-related disease biomarker discovery. Extensive proteome profiling has been conducted for CSF, but studies aimed at unraveling site-specific CSF N-glycoproteome are lacking. Initial efforts into site-specific N-glycoproteomics study in CSF yield limited coverage, hindering further experimental design of glycosylation-based disease biomarker discovery in CSF. In the present study, we have developed an N-glycoproteomic approach that combines enhanced N-glycopeptide sequential enrichment by hydrophilic interaction chromatography (HILIC) and boronic acid enrichment with electron transfer and higher-energy collision dissociation (EThcD) for large-scale intact N-glycopeptide analysis. The application of the developed approach to the analyses of human CSF samples enabled identifications of a total of 2893 intact N-glycopeptides from 511 N-glycosites and 285 N-glycoproteins. To our knowledge, this is the largest site-specific N-glycoproteome dataset reported for CSF to date. Such dataset provides molecular basis for a better understanding of the structure–function relationships of glycoproteins and their roles in CNS-related physiological and pathological processes. As accumulating evidence suggests that defects in glycosylation are involved in Alzheimer's disease (AD) pathogenesis, in the present study, a comparative in-depth N-glycoproteomic analysis was conducted for CSF samples from healthy control and AD patients, which yielded a comparable N-glycoproteome coverage but a distinct expression pattern for different categories of glycoforms, such as decreased fucosylation in AD CSF samples. Altered glycosylation patterns were detected for a number of N-glycoproteins including alpha-1-antichymotrypsin, ephrin-A3 and carnosinase CN1 etc., which serve as potentially interesting targets for further glycosylation-based AD study and may eventually lead to molecular elucidation of the role of glycosylation in AD progression. [Display omitted] •Efficient N-glycopeptide sequential enrichment by HILIC and boronic acid enrichment.•Site-specific intact N-glycopeptide characterization using EThcD.•In-depth site-specific N-glycoproteome analysis in human CSF.•Mapping the landscape of glycosylation patterns in Alzheimer's disease. An exploratory glycosylation-based biomarker study has been conducted for in-depth mapping of an overall glycosylation landscape and site-specific alteration in glycoproteome collected from cerebrospinal fluids (CSF) in healthy control and Alzheimer’s disease (AD) subjects. The comparison will shed light on the glycoproteome profile, dominant glycosylation differences and similarities, and some of the interesting glycoprotein candidates with specific glycosylation pattern alterations in AD. |
| ArticleNumber | 100081 |
| Author | Yu, Qing Carlsson, Cynthia Huang, Junfeng Chen, Zhengwei Okonkwo, Ozioma Yu, Qinying Asthana, Sanjay Zhong, Xiaofang Johnson, Jillian Li, Lingjun Shipman, Richard |
| Author_xml | – sequence: 1 givenname: Zhengwei surname: Chen fullname: Chen, Zhengwei organization: Department of Chemistry, University of Wisconsin, Madison, Wisconsin, USA – sequence: 2 givenname: Qinying surname: Yu fullname: Yu, Qinying organization: School of Pharmacy, University of Wisconsin, Madison, Wisconsin, USA – sequence: 3 givenname: Qing surname: Yu fullname: Yu, Qing organization: School of Pharmacy, University of Wisconsin, Madison, Wisconsin, USA – sequence: 4 givenname: Jillian surname: Johnson fullname: Johnson, Jillian organization: School of Pharmacy, University of Wisconsin, Madison, Wisconsin, USA – sequence: 5 givenname: Richard orcidid: 0000-0003-4731-5563 surname: Shipman fullname: Shipman, Richard organization: Department of Applied Science, University of Wisconsin-Stout, Menomonie, Wisconsin, USA – sequence: 6 givenname: Xiaofang surname: Zhong fullname: Zhong, Xiaofang organization: School of Pharmacy, University of Wisconsin, Madison, Wisconsin, USA – sequence: 7 givenname: Junfeng surname: Huang fullname: Huang, Junfeng organization: School of Pharmacy, University of Wisconsin, Madison, Wisconsin, USA – sequence: 8 givenname: Sanjay surname: Asthana fullname: Asthana, Sanjay organization: School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, USA – sequence: 9 givenname: Cynthia surname: Carlsson fullname: Carlsson, Cynthia organization: School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, USA – sequence: 10 givenname: Ozioma surname: Okonkwo fullname: Okonkwo, Ozioma organization: School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, USA – sequence: 11 givenname: Lingjun surname: Li fullname: Li, Lingjun email: lingjun.li@wisc.edu organization: Department of Chemistry, University of Wisconsin, Madison, Wisconsin, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33862227$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kUtvEzEUhS1URB_wC5CQd7CZYHueWYAUBfqQIlgAa8tj30lu5LEHe6ZS-An8ajxNWwGLrmxdf-cc655zcuK8A0Jec7bgjFfv94teD8EvBBM8TRhr-DNyxsu8zJZFU5w83uvqlJzHuGdMMF6XL8hpnjeVEKI-I79vXGZgGHf0G46QxQE0dqjpyil7iBip7-iXbGsP2qesEXwPFB29nnrl6BoCtMHHARNNL-2Ehipn6NWMx4NVI3pHN2kUtRqArnfKbSHOBiv7awfYQ3gb6SeMoCK8JM87ZSO8uj8vyI_Lz9_X19nm69XNerXJdFEux0zleam5gMYAdGXLTN4smaq5qYQxquSm5UwrrUW9nBnOoWjaogPVaKh12eQX5OPRd5jaHowGNwZl5RCwV-EgvUL574vDndz6W9nUoqjyKhm8uzcI_ucEcZQ9Rg3WKgd-ilKUvKhY-ixP6Ju_sx5DHgpIwPII6LTHGKCTGse7vaVotJIzOZct9_KubDmXLY9lJ23-n_bB_mnVh6MK0o5vEYKMGsFpMBhAj9J4fFL_B0HryDs |
| CitedBy_id | crossref_primary_10_1002_mco2_261 crossref_primary_10_1016_j_jbc_2024_105683 crossref_primary_10_3390_ijms24031937 crossref_primary_10_1016_j_molmed_2022_01_004 crossref_primary_10_1016_j_trac_2023_117290 crossref_primary_10_1016_j_mcpro_2022_100205 crossref_primary_10_3390_ijms23031609 crossref_primary_10_1016_j_sbi_2022_102371 crossref_primary_10_1002_fft2_290 crossref_primary_10_1021_jasms_4c00052 crossref_primary_10_1002_pmic_202300620 crossref_primary_10_1186_s12935_022_02572_4 crossref_primary_10_1007_s12272_022_01408_z crossref_primary_10_1016_j_teac_2024_e00232 crossref_primary_10_1016_j_tem_2021_09_006 crossref_primary_10_1016_j_foodres_2022_111938 crossref_primary_10_1021_acs_jproteome_3c00496 crossref_primary_10_1038_s42003_023_04439_4 crossref_primary_10_1016_j_mcpro_2021_100086 crossref_primary_10_1016_j_ijbiomac_2024_139303 crossref_primary_10_3390_biom11060858 crossref_primary_10_1016_j_tifs_2022_07_017 crossref_primary_10_1021_jacs_4c14454 crossref_primary_10_1016_j_ijms_2022_116947 crossref_primary_10_1021_acs_analchem_2c01773 crossref_primary_10_1002_mas_21771 crossref_primary_10_1038_s43586_022_00128_4 crossref_primary_10_1021_acschembio_1c00932 crossref_primary_10_3724_SP_J_1123_2021_06011 crossref_primary_10_1093_nsr_nwac059 crossref_primary_10_3390_cells11081279 crossref_primary_10_1021_acs_analchem_3c04484 crossref_primary_10_1126_sciadv_adk6911 crossref_primary_10_1016_j_mcpro_2023_100595 crossref_primary_10_1038_s43586_023_00205_2 crossref_primary_10_1021_acs_jproteome_3c00015 crossref_primary_10_1007_s11357_024_01133_z crossref_primary_10_1016_j_jbc_2023_105624 crossref_primary_10_1021_acs_analchem_1c04503 crossref_primary_10_1021_acs_analchem_3c00408 crossref_primary_10_1038_s41551_023_01067_5 crossref_primary_10_1016_j_jprot_2022_104507 crossref_primary_10_3389_fchem_2021_707387 crossref_primary_10_1080_14789450_2024_2418491 crossref_primary_10_1016_j_mcpro_2023_100540 crossref_primary_10_1016_j_mcpro_2022_100433 crossref_primary_10_1016_j_arr_2023_101991 crossref_primary_10_1002_alz_12523 crossref_primary_10_1002_mas_21792 crossref_primary_10_1002_mco2_674 crossref_primary_10_1016_j_chroma_2022_463721 crossref_primary_10_1038_s41420_023_01617_5 crossref_primary_10_1111_1541_4337_13395 |
| Cites_doi | 10.1016/j.ijms.2017.09.002 10.1007/s12035-012-8234-4 10.1002/jms.3069 10.1074/mcp.O115.049627 10.1007/s00401-009-0536-x 10.1186/s12014-019-9254-0 10.1021/acs.analchem.5b01835 10.1016/j.molcel.2012.04.031 10.1101/gad.2.2.259 10.1523/JNEUROSCI.21-05-01444.2001 10.1038/nmeth.1392 10.1021/bp034378n 10.1093/brain/awl255 10.1039/C4CS00529E 10.1093/nar/gkh131 10.1021/cn500099f 10.1242/jcs.034058 10.1074/mcp.M113.033977 10.1093/glycob/cwj110 10.1007/s12035-012-8237-1 10.1016/S0167-4838(00)00153-9 10.1155/2006/241817 10.1002/mas.20221 10.1021/pr200780j 10.1021/pr301130k 10.1074/jbc.M112.365643 10.1016/j.bbrc.2007.04.096 10.1016/j.ab.2005.10.036 10.1021/ac100530w 10.1074/mcp.O115.057638 10.1016/j.cell.2006.08.019 10.1074/mcp.M111.011601 10.3109/13547500903108423 10.1096/fj.14-255414 10.1021/bi200218s 10.1016/j.cbpa.2017.10.007 10.1096/fj.03-1040fje 10.1111/febs.12590 10.1016/j.brainres.2009.01.058 10.1021/cr000423j 10.1016/j.neuroscience.2010.05.022 10.1021/jacs.5b06586 10.1097/00002093-199509020-00009 10.1074/jbc.M113.464008 10.1073/pnas.0601279103 10.1021/acs.analchem.8b04580 10.2169/internalmedicine.54.2876 10.1074/jbc.M311601200 10.3233/JAD-131088 10.1074/jbc.M305858200 10.1016/j.neurobiolaging.2014.11.006 10.1385/JMN:18:1-2:53 10.1016/j.bbcan.2015.08.003 10.1002/prca.200700081 10.1002/jssc.201200434 10.1073/pnas.0400348101 10.1146/annurev-pharmtox-011112-140226 10.1038/nrc3982 10.1021/acs.jproteome.0c00270 10.1021/acs.analchem.0c01136 10.1194/jlr.R075796 10.1111/j.1460-9568.2006.04735.x 10.1128/IAI.72.4.1946-1955.2004 10.1021/pr500893m 10.1038/nrm.2015.16 10.1002/pmic.200300764 10.1093/glycob/cwj081 10.1159/000147479 10.1093/glycob/cws112 10.1074/jbc.M209764200 10.1186/alzrt265 10.1016/j.bbrc.2014.06.067 10.1074/jbc.272.11.7229 10.1111/jnc.13216 10.1016/j.trac.2018.10.009 10.4161/pri.26746 10.3171/jns.1983.59.3.0369 10.1021/acs.jproteome.6b00438 10.1016/j.jprot.2008.04.005 10.3233/JAD-2006-9309 10.1046/j.1471-4159.2001.00144.x 10.1016/j.jprot.2015.10.006 10.1111/j.1471-4159.2010.06647.x 10.1073/pnas.0500607102 10.1016/j.cellsig.2011.11.016 10.3233/JAD-2009-0966 10.1523/JNEUROSCI.20-20-07505.2000 10.1021/acs.jproteome.6b00098 10.1007/s13361-017-1701-4 10.1074/jbc.M116.770123 10.1021/acs.jproteome.0c00291 10.1074/jbc.M006201200 10.1016/j.brainres.2014.08.022 10.1038/nn1576 10.1007/s10719-015-9626-2 10.3389/fnmol.2018.00483 10.1016/j.carres.2009.04.028 10.1016/1357-2725(96)00032-5 10.1039/C8AN00216A 10.1074/jbc.M114.631622 10.1007/s00216-017-0387-6 10.1517/14728222.2013.789862 10.1186/1742-4933-7-S1-S6 10.1038/372092a0 10.1038/nmeth.1322 10.1136/gut.51.2.169 10.1016/j.clineuro.2008.12.004 10.1016/0197-4580(96)00112-1 10.1016/j.neuron.2019.12.015 10.1016/j.talanta.2013.06.031 10.1074/jbc.M512769200 10.1186/1750-1326-9-22 10.1021/bi9013775 10.1021/acs.analchem.9b01698 10.1093/clinchem/34.5.911 10.1186/gb-2003-4-9-r60 10.1021/ac503276z 10.1007/BF00711896 10.1038/nchembio.797 10.1021/ac3025366 10.1021/pr0502065 10.1074/jbc.M303480200 10.2337/db09-0868 10.1021/pr400861m 10.1039/c3ra42960a 10.1016/j.cell.2010.04.012 10.1016/S0002-9440(10)64839-0 10.1080/19336950.2016.1138189 10.1155/2006/202938 10.1002/0471250953.bi1320s40 10.1002/prca.201600009 10.1101/gad.1630408 10.1002/rcm.7125 10.1021/acs.jproteome.9b00525 10.1002/elps.200900210 10.1016/j.nbd.2009.03.002 10.1074/mcp.M114.038554 10.1016/S0304-4165(99)00165-8 10.1038/s41592-020-0967-9 |
| ContentType | Journal Article |
| Copyright | 2021 The Authors Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved. 2021 The Authors 2021 |
| Copyright_xml | – notice: 2021 The Authors – notice: Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved. – notice: 2021 The Authors 2021 |
| DBID | 6I. AAFTH AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 5PM |
| DOI | 10.1016/j.mcpro.2021.100081 |
| DatabaseName | ScienceDirect Open Access Titles Elsevier:ScienceDirect:Open Access CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Anatomy & Physiology Biology |
| EISSN | 1535-9484 |
| ExternalDocumentID | PMC8724636 33862227 10_1016_j_mcpro_2021_100081 S1535947621000542 |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GrantInformation_xml | – fundername: NIA NIH HHS grantid: RF1 AG052324 – fundername: NIGMS NIH HHS grantid: P41 GM108538 – fundername: NIDDK NIH HHS grantid: R01 DK071801 – fundername: NIA NIH HHS grantid: R21 AG065728 – fundername: NCI NIH HHS grantid: U01 CA231081 – fundername: NCRR NIH HHS grantid: S10 RR029531 – fundername: NIA NIH HHS grantid: P30 AG062715 |
| GroupedDBID | --- 0SF 123 18M 29M 2WC 34G 39C 4.4 53G 5VS 6I. AAEDW AAFTH AAFWJ AAXUO ABDNZ ACGFO ACIWK ACPRK ACYGS ADBBV AENEX AEXQZ AFPKN AFRAH ALMA_UNASSIGNED_HOLDINGS AMRAJ AOIJS BAWUL BTFSW C1A CS3 DIK DU5 E3Z EBS EJD F5P FDB FRP GROUPED_DOAJ GX1 HH5 HYE KQ8 OK1 P2P RHF RHI RNS ROL RPM TBC TR2 W8F WOQ ZA5 0R~ AALRI AAYWO AAYXX ACVFH ADCNI ADVLN AEUPX AFPUW AIGII AITUG AKBMS AKRWK AKYEP CITATION H13 CGR CUY CVF ECM EIF NPM 7X8 5PM |
| ID | FETCH-LOGICAL-c459t-a335c12e8deef5b0d3890a71d62dda51db10cacc279e8de11e48b4fea8ce7c583 |
| ISSN | 1535-9476 1535-9484 |
| IngestDate | Thu Aug 21 18:25:56 EDT 2025 Fri Jul 11 09:12:02 EDT 2025 Thu Apr 03 07:04:19 EDT 2025 Tue Jul 01 03:35:29 EDT 2025 Thu Apr 24 22:54:17 EDT 2025 Fri Feb 23 02:36:49 EST 2024 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | APP ABC site-specific intact glycopeptide characterization AD SDS DMSO DTT IAA PTM glycopeptide enrichment CNS ADRC EThcD PBA TFA N-glycoproteome analysis WGA RCA electron-transfer higher-energy collision induced dissociation (EThcD) FDR cerebrospinal fluid CSF HILIC ConA |
| Language | English |
| License | This is an open access article under the CC BY license. Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c459t-a335c12e8deef5b0d3890a71d62dda51db10cacc279e8de11e48b4fea8ce7c583 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 These authors contributed equally to this work. |
| ORCID | 0000-0003-4731-5563 |
| OpenAccessLink | http://dx.doi.org/10.1016/j.mcpro.2021.100081 |
| PMID | 33862227 |
| PQID | 2514604591 |
| PQPubID | 23479 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_8724636 proquest_miscellaneous_2514604591 pubmed_primary_33862227 crossref_citationtrail_10_1016_j_mcpro_2021_100081 crossref_primary_10_1016_j_mcpro_2021_100081 elsevier_sciencedirect_doi_10_1016_j_mcpro_2021_100081 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2021-01-01 |
| PublicationDateYYYYMMDD | 2021-01-01 |
| PublicationDate_xml | – month: 01 year: 2021 text: 2021-01-01 day: 01 |
| PublicationDecade | 2020 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | Molecular & cellular proteomics |
| PublicationTitleAlternate | Mol Cell Proteomics |
| PublicationYear | 2021 |
| Publisher | Elsevier Inc American Society for Biochemistry and Molecular Biology |
| Publisher_xml | – name: Elsevier Inc – name: American Society for Biochemistry and Molecular Biology |
| References | Kalsheker (bib81) 1996; 28 Schedin-Weiss, Winblad, Tjernberg (bib16) 2014; 281 Apweiler, Hermjakob, Sharon (bib35) 1999; 1473 Pan, Bai, Ma, Deng, Qin, Qian (bib25) 2013; 115 Dente, Rüther, Tripodi, Wagner, Cortese (bib67) 1988; 2 Barquilla, Pasquale (bib95) 2015; 55 Mucke, Yu, McConlogue, Rockenstein, Abraham, Masliah (bib86) 2000; 157 Carlo (bib111) 2013; 7 Zielinska, Gnad, Schropp, Wiśniewski, Mann (bib30) 2012; 46 Yin, Lee, Cho, Suk (bib127) 2009; 1265 Marino, Bern, Mommen, Leney, van Gaans-van den Brink, Bonvin, Becker, van Els, Heck (bib50) 2015; 137 Bern, Kil (bib33) 2011; 10 Farriol-Mathis, Garavelli, Boeckmann, Duvaud, Gasteiger, Gateau, Veuthey, Bairoch (bib61) 2004; 4 Krog, Bock (bib131) 1991; 27 Spagnuolo, Maresca, La Marca, Carrizzo, Veronesi, Cupidi, Piccoli, Maletta, Bruni, Abrescia, Cigliano (bib136) 2014; 5 Sarkar, Leventis, Silvescu, Reinhold, Schachter, Boulianne (bib69) 2006; 281 Licastro, Parnetti, Morini, Davis, Cucinotta, Gaiti, Senin (bib82) 1995; 9 Chen, Fu, Ip (bib94) 2012; 24 Shinohara, Tachibana, Kanekiyo, Bu (bib151) 2017; 58 Cunningham, Wang, Wellner, Li (bib28) 2012; 47 Arvanitis, Davy (bib93) 2008; 22 Zhu, Chen, Zhang, An, Wu, Yu, Skilton, Bern, Ilker Sen, Li, Lubman (bib39) 2018; 18 Joosten, Cohen, Ritter, Batt, Shuler (bib72) 2004; 20 Wang, Cunningham, Zetterberg, Asthana, Carlsson, Okonkwo, Li (bib23) 2016; 10 Rudd, Morgan, Wormald, Harvey, van den Berg, Davis, Ferguson, Dwek (bib124) 1997; 272 Harazono, Kawasaki, Itoh, Hashii, Ishii-Watabe, Kawanishi, Hayakawa (bib134) 2006; 348 Thaysen-Andersen, Larsen, Packer, Palmisano (bib46) 2013; 3 Sethi, Thaysen-Andersen, Smith, Baker, Packer, Hancock, Fanayan (bib73) 2013; 13 Padmanabhan, Levy, Dickson, Potter (bib87) 2006; 129 Li, Lu, Wang, Gong (bib17) 2006; 23 Nilsson, Bales, DiCarlo, Gordon, Morgan, Paul, Potter (bib85) 2001; 21 Balog, Stavenhagen, Fung, Koeleman, McDonnell, Verhoeven, Mesker, Tollenaar, Deelder, Wuhrer (bib74) 2012; 11 Ferluga, Hantgan, Goldgur, Himanen, Nikolov, Debinski (bib96) 2013; 288 Hulleman, Kelly (bib119) 2015; 29 Glover, Yu, Chen, Shi, Kent, Li (bib42) 2018; 427 Clerc, Reiding, Jansen, Kammeijer, Bondt, Wuhrer (bib121) 2016; 33 Bruggink, Kuiperij, Gloerich, Otte-Höller, Rozemuller, Claassen, Küsters, Verbeek (bib145) 2015; 134 Palmigiano, Barone, Sturiale, Sanfilippo, Bua, Romeo, Messina, Capuana, Maci, Le Pira, Zappia, Garozzo (bib20) 2016; 131 Langer, Guo, Shashikanth, Pierce, Leckband (bib104) 2012; 125 Barrack (bib98) 2013 Harrington, Fonteh, Biringer, Hühmer, Cowan (bib141) 2006; 22 Parry, Hanisch, Leir, Sutton-Smith, Morris, Dell, Harris (bib63) 2006; 16 Zhang, Zhang, Jiang, Yang, Lu (bib36) 2015; 44 Frost, Greer, Li (bib100) 2014; 87 Kendziorski, Irizarry, Chen, Haag, Gould (bib80) 2005; 102 Lee, Moh, Parker, Bern, Packer, Thaysen-Andersen (bib34) 2016; 15 Kaden, Voigt, Munter, Bobowski, Schaefer, Multhaup (bib144) 2009; 122 Chen, Yu, Hao, Liu, Johnson, Tian, Kao, Xu, Li (bib38) 2018; 143 Frese, Zhou, Taus, Altelaar, Mechtler, Heck, Mohammed (bib48) 2013; 12 Schachter (bib70) 2009; 344 Regeniter, Kuhle, Mehling, Möller, Wurster, Freidank, Siede (bib3) 2009; 111 Svensson, Hyrenius Wittsten, Linse, Mani (bib109) 2011; 50 Thaysen-Andersen, Venkatakrishnan, Loke, Laurini, Diestel, Parker, Packer (bib76) 2015; 290 Liu, Gu, Scafidi, Davis (bib138) 2004; 72 Chen, Huang, Li (bib13) 2019; 118 Sun, Hu, Ao, Shah, Chen, Yang, Jia, Tian, Thomas, Zhang (bib54) 2019; 16 Bai, Wang, Li, Chen, Yu, Dey, Yarbro, Han, Lutz, Rao, Jiao, Sifford, Han, Wang, Tan (bib58) 2020; 105 Morawski, Brückner, Jäger, Seeger, Arendt (bib108) 2010; 169 Roher, Maarouf, Sue, Hu, Wilson, Beach (bib122) 2009; 14 Chacón, del Marco, Arévalo, Domínguez-Giménez, García-Segura, Rodríguez-Tébar (bib105) 2015; 36 Zhu, Huang, Zhang, Chen, Lin, Grigorean, Li, Liu, Singal, Parikh, Lubman (bib41) 2020; 19 Liu, Zeng, Fang, Cao, Liu, Yan, Zhang, Peng, Wu, Zhang (bib55) 2017; 8 Mysling, Palmisano, Højrup, Thaysen-Andersen (bib47) 2010; 82 Deeb, Cox, Schmidt-Supprian, Mann (bib29) 2014; 13 Ma, Brewer, Potter (bib84) 1996; 17 Viapiano, Matthews, Hockfield (bib116) 2003; 278 Parnetti, Balducci, Pierguidi, De Carlo, Peducci, D'Amore, Padiglioni, Mastrocola, Persichetti, Paciotti, Bellomo, Tambasco, Rossi, Beccari, Calabresi (bib133) 2009; 34 Batth, Francavilla, Olsen (bib44) 2014; 13 Chen, Glover, Li (bib12) 2018; 42 Eggert, Paliga, Soba, Evin, Masters, Weidemann, Beyreuther (bib143) 2004; 279 Martiskainen, Haapasalo, Kurkinen, Pihlajamäki, Soininen, Hiltunen (bib150) 2013; 17 Dennis, Sherman, Hosack, Yang, Gao, Lane, Lempicki (bib57) 2003; 4 Hirai, Pang, Bao, Miyazaki, Li, Miura, Parris, Rong, Watanabe, Yuzaki, Morgan (bib106) 2005; 8 Kania, Klein (bib91) 2016; 17 Cao, Yu, Liu, Chen, Li (bib43) 2019; 19 Segal (bib1) 1993; 16 Fournier, Medjoubi-N, Porquet (bib66) 2000; 1482 Zhong, Wang, Carlsson, Okonkwo, Zetterberg, Li (bib53) 2019; 11 Nilsson, Rüetschi, Halim, Hesse, Carlsohn, Brinkmalm, Larson (bib21) 2009; 6 Goyallon, Cholet, Chapelle, Junot, Fenaille (bib22) 2015; 29 Chen, Zhong, Tie, Chen, Zhang, Li (bib11) 2017; 409 Yu, Zhong, Chen, Feng, Ma, Diamond, Voeller, Kim, DeSantes, Capitini, Patel, Hoover-Regan, Burke, Janko, Puccetti (bib7) 2020; 19 Polasky, Yu, Teo, Nesvizhskii (bib56) 2020; 17 Lukiw, Alexandrov (bib118) 2012; 46 Chugh, Gnanapragassam, Jain, Rachagani, Ponnusamy, Batra (bib65) 2015; 1856 Bern, Kil, Becker (bib32) 2012; 40 Zhang, Ye, Xue, Shu, Zhou, Ji, Fu, Wang, Yang (bib24) 2016; 15 Lundström, Yang, Lyutvinskiy, Rutishauser, Herukka, Soininen, Zubarev (bib142) 2014; 38 Ohtsubo, Marth (bib9) 2006; 126 Fonteh, Harrington, Huhmer, Biringer, Riggins, Harrington (bib6) 2006; 22 Ajmo, Bailey, Howell, Cortez, Pennypacker, Mehta, Morgan, Gordon, Gottschall (bib117) 2010; 113 Huang, Dong, Shi, Chen, Cui, Liu, Ye, Li (bib40) 2019; 91 Watanabe, Araki, Chui, Makifuchi, Ihara, Tabira (bib110) 2004; 18 Yang, Li, Meri, Rogers, Shen (bib123) 2000; 20 Taniguchi, Okayama, Hashimoto, Kitaura, Jimbo, Wakutani, Wada-Isoe, Nakashima, Akatsu, Furukawa, Arai, Urakami (bib125) 2008; 26 Hansson, Andréasson, Wall, Skoog, Andreasen, Wallin, Zetterberg, Blennow (bib140) 2009; 16 Guldbrandsen, Vethe, Farag, Oveland, Garberg, Berle, Myhr, Opsahl, Barsnes, Berven (bib8) 2014; 13 Frese, Altelaar, van den Toorn, Nolting, Griep-Raming, Heck, Mohammed (bib49) 2012; 84 Abdi, Quinn, Jankovic, McIntosh, Leverenz, Peskind, Nixon, Nutt, Chung, Zabetian, Samii, Lin, Hattan, Pan, Wang (bib4) 2006; 9 Zhang (bib5) 2007; 1 Kitagishi, Nakanishi, Ogura, Matsuda (bib148) 2014; 6 McComb (bib2) 1983; 59 Roth (bib59) 2002; 102 Ohsawa, Takamura, Kohsaka (bib120) 2001; 76 Laine, Davril, Rabaud, Vercaigne-Marko, Hayem (bib88) 1985; 151 Zhong, Frost, Yu, Li, Gu, Li (bib102) 2020; 92 Ondacova, Karmazinova, Lazniewska, Weiss, Lacinova (bib112) 2016; 10 Yagi, Saito, Yanagisawa, Robert, Kato (bib71) 2012; 287 Leshchyns'ka, Sytnyk (bib103) 2016; 2016 Zielinska, Gnad, Wiśniewski, Mann (bib26) 2010; 141 Zhong, Yu, Ma, Frost, Lu, Chen, Zetterberg, Carlsson, Okonkwo, Li (bib101) 2019; 91 Hwang, Zhang, Chung, Leverenz, Zabetian, Peskind, Jankovic, Su, Hancock, Pan, Montine, Pan, Nutt, Albin, Gearing (bib15) 2010; 29 Riedl, Koeppel, Pfister, Peters, Sauerhoefer, Sternik, Brinkkoetter, Zentgraf, Navis, Henning, Van Den Born, Bakker, Janssen, van der Woude, Yard (bib99) 2010; 59 Arendt (bib130) 2009; 118 Apweiler, Bairoch, Wu, Barker, Boeckmann, Ferro, Gasteiger, Huang, Lopez, Magrane, Martin, Natale, O'Donovan, Redaschi, Yeh (bib60) 2004; 32 Liu, Qian, Gritsenko, Camp, Monroe, Moore, Smith (bib52) 2005; 4 He (bib146) 2008 Ongay, Boichenko, Govorukhina, Bischoff (bib37) 2012; 35 Liu, Iqbal, Grundke-Iqbal, Hart, Gong (bib18) 2004; 101 Kobayashi, Ogata, Morikawa, Iijima, Harada, Yoshida, Brown, Inoue, Hamada, Ishii, Watanabe, Hibi (bib62) 2002; 51 Zhu, He, Johnson, Stoops, Eaker, Stoffer, Bell, Zarnegar, DeFrances (bib147) 2007; 358 Song, Kim, Chung, Cho (bib137) 2015; 54 Hachulla, Laine, Hayem (bib89) 1988; 34 Pinho, Reis (bib10) 2015; 15 Diz, Truebano, Skibinski (bib79) 2009; 30 Baycin-Hizal, Gottschalk, Jacobson, Mai, Wolozny, Zhang, Krag, Betenbaugh (bib113) 2014; 453 Thaysen-Andersen, Packer, Schulz (bib78) 2016; 15 Ma, Yee, Brewer, Das, Potter (bib83) 1994; 372 Teufel, Saudek, Ledig, Bernhardt, Boularand, Carreau, Cairns, Carter, Cowley, Duverger, Ganzhorn, Guenet, Heintzelmann, Laucher, Sauvage (bib97) 2003; 278 Botella-Lopez, Burgaya, Gavin, Garcia-Ayllon, Gomez-Tortosa, Pena-Casanova, Urena, Del Rio, Blesa, Soriano, Saez-Valero (bib149) 2006; 103 Faid, Evjen, Tollersrud, Michalski, Morelle (bib132) 2006; 16 Yu, Wang, Chen, Urabe, Glover, Shi, Guo, Kent, Li (bib51) 2017; 28 Sparbier, Koch, Kessler, Wenzel, Kostrzewa (bib45) 2005; 16 Ianni, Manerba, Di Stefano, Porcellini, Chiappelli, Carbone, Licastro (bib92) 2010; 7 Takemoto, Berry, Bellinger (bib153) 2010; 20 Kristinsson, Snaedal, Tórsdóttir, Jóhannesson (bib135) 2012; 8 Everest-Dass, Jin, Thaysen-Andersen, Nevalainen, Kolarich, Packer (bib75) 2012; 22 May, Bock, Nimpf, Herz (bib152) 2003; 278 Zhong, Chen, Snovida, Liu, Rogers, Li (bib14) 2015; 87 Yuzwa, Shan, Macauley, Clark, Skorobogatko, Vosseller, Vocadlo (bib19) 2012; 8 Pratta, Tortorella, Arner (bib107) 2000; 275 Wang, Yuan, Fan, Karch, Ball, Denu, Garcia (bib31) 2016; 15 Wildsmith, Schauer, Smith, Arnott, Zhu, Haznedar, Kaur, Mathews, Honigberg (bib126) 2014; 9 Crehan, Hardy, Pocock (bib139) 2012; 2012 Taniguchi, Woodward, Magnelli, McColgan, Lehoux, Jacobo, Mauris, Argüeso (bib64) 2017; 292 Wiśniewski, Zougman, Nagaraj, Mann (bib27) 2009; 6 Ajit, Richard, Jeffrey, Hudson, Gerald, Jamey (bib77) 2009 Imre, Kremmer, Heberger, Molnár-Szöllősi, Ludanyi, Pocsfalvi, Malorni, Drahos, Vekey (bib68) 2008; 71 Yu, Tan (bib114) 2012; 45 Marksteiner, Kaufmann, Gurka, Humpel (bib115) 2002; 18 Meyer, Giddens, Coleman, Hall (bib129) 2014; 1585 Laine, Hachulla, Strecker, Michalski, Wieruszeski (bib90) 1991; 197 Dunham, Meyer, Garcia, Hall (bib128) 2009; 48 Harazono (10.1016/j.mcpro.2021.100081_bib134) 2006; 348 Schedin-Weiss (10.1016/j.mcpro.2021.100081_bib16) 2014; 281 Spagnuolo (10.1016/j.mcpro.2021.100081_bib136) 2014; 5 Chacón (10.1016/j.mcpro.2021.100081_bib105) 2015; 36 Yu (10.1016/j.mcpro.2021.100081_bib51) 2017; 28 Regeniter (10.1016/j.mcpro.2021.100081_bib3) 2009; 111 Leshchyns'ka (10.1016/j.mcpro.2021.100081_bib103) 2016; 2016 Sparbier (10.1016/j.mcpro.2021.100081_bib45) 2005; 16 Everest-Dass (10.1016/j.mcpro.2021.100081_bib75) 2012; 22 Abdi (10.1016/j.mcpro.2021.100081_bib4) 2006; 9 Lundström (10.1016/j.mcpro.2021.100081_bib142) 2014; 38 Parry (10.1016/j.mcpro.2021.100081_bib63) 2006; 16 Rudd (10.1016/j.mcpro.2021.100081_bib124) 1997; 272 Fonteh (10.1016/j.mcpro.2021.100081_bib6) 2006; 22 Liu (10.1016/j.mcpro.2021.100081_bib138) 2004; 72 Harrington (10.1016/j.mcpro.2021.100081_bib141) 2006; 22 Langer (10.1016/j.mcpro.2021.100081_bib104) 2012; 125 Joosten (10.1016/j.mcpro.2021.100081_bib72) 2004; 20 Batth (10.1016/j.mcpro.2021.100081_bib44) 2014; 13 Farriol-Mathis (10.1016/j.mcpro.2021.100081_bib61) 2004; 4 Sarkar (10.1016/j.mcpro.2021.100081_bib69) 2006; 281 Nilsson (10.1016/j.mcpro.2021.100081_bib21) 2009; 6 Kania (10.1016/j.mcpro.2021.100081_bib91) 2016; 17 Arendt (10.1016/j.mcpro.2021.100081_bib130) 2009; 118 Zielinska (10.1016/j.mcpro.2021.100081_bib30) 2012; 46 Pratta (10.1016/j.mcpro.2021.100081_bib107) 2000; 275 Roher (10.1016/j.mcpro.2021.100081_bib122) 2009; 14 Zhu (10.1016/j.mcpro.2021.100081_bib147) 2007; 358 Yu (10.1016/j.mcpro.2021.100081_bib114) 2012; 45 Mucke (10.1016/j.mcpro.2021.100081_bib86) 2000; 157 Liu (10.1016/j.mcpro.2021.100081_bib18) 2004; 101 Carlo (10.1016/j.mcpro.2021.100081_bib111) 2013; 7 Ma (10.1016/j.mcpro.2021.100081_bib84) 1996; 17 Ianni (10.1016/j.mcpro.2021.100081_bib92) 2010; 7 Krog (10.1016/j.mcpro.2021.100081_bib131) 1991; 27 Hwang (10.1016/j.mcpro.2021.100081_bib15) 2010; 29 Li (10.1016/j.mcpro.2021.100081_bib17) 2006; 23 Pan (10.1016/j.mcpro.2021.100081_bib25) 2013; 115 Zhong (10.1016/j.mcpro.2021.100081_bib101) 2019; 91 Ongay (10.1016/j.mcpro.2021.100081_bib37) 2012; 35 Meyer (10.1016/j.mcpro.2021.100081_bib129) 2014; 1585 Zhu (10.1016/j.mcpro.2021.100081_bib41) 2020; 19 Polasky (10.1016/j.mcpro.2021.100081_bib56) 2020; 17 Bern (10.1016/j.mcpro.2021.100081_bib33) 2011; 10 Chen (10.1016/j.mcpro.2021.100081_bib94) 2012; 24 Laine (10.1016/j.mcpro.2021.100081_bib90) 1991; 197 Takemoto (10.1016/j.mcpro.2021.100081_bib153) 2010; 20 Nilsson (10.1016/j.mcpro.2021.100081_bib85) 2001; 21 Schachter (10.1016/j.mcpro.2021.100081_bib70) 2009; 344 Zhang (10.1016/j.mcpro.2021.100081_bib5) 2007; 1 Thaysen-Andersen (10.1016/j.mcpro.2021.100081_bib76) 2015; 290 Bai (10.1016/j.mcpro.2021.100081_bib58) 2020; 105 Zhong (10.1016/j.mcpro.2021.100081_bib53) 2019; 11 Sun (10.1016/j.mcpro.2021.100081_bib54) 2019; 16 Barrack (10.1016/j.mcpro.2021.100081_bib98) 2013 Lukiw (10.1016/j.mcpro.2021.100081_bib118) 2012; 46 Hachulla (10.1016/j.mcpro.2021.100081_bib89) 1988; 34 Goyallon (10.1016/j.mcpro.2021.100081_bib22) 2015; 29 Hulleman (10.1016/j.mcpro.2021.100081_bib119) 2015; 29 Wiśniewski (10.1016/j.mcpro.2021.100081_bib27) 2009; 6 Frost (10.1016/j.mcpro.2021.100081_bib100) 2014; 87 Yang (10.1016/j.mcpro.2021.100081_bib123) 2000; 20 Martiskainen (10.1016/j.mcpro.2021.100081_bib150) 2013; 17 Yu (10.1016/j.mcpro.2021.100081_bib7) 2020; 19 Liu (10.1016/j.mcpro.2021.100081_bib52) 2005; 4 Ferluga (10.1016/j.mcpro.2021.100081_bib96) 2013; 288 Apweiler (10.1016/j.mcpro.2021.100081_bib60) 2004; 32 Song (10.1016/j.mcpro.2021.100081_bib137) 2015; 54 Cunningham (10.1016/j.mcpro.2021.100081_bib28) 2012; 47 Chugh (10.1016/j.mcpro.2021.100081_bib65) 2015; 1856 Taniguchi (10.1016/j.mcpro.2021.100081_bib125) 2008; 26 Wang (10.1016/j.mcpro.2021.100081_bib23) 2016; 10 Cao (10.1016/j.mcpro.2021.100081_bib43) 2019; 19 Hirai (10.1016/j.mcpro.2021.100081_bib106) 2005; 8 Licastro (10.1016/j.mcpro.2021.100081_bib82) 1995; 9 Barquilla (10.1016/j.mcpro.2021.100081_bib95) 2015; 55 Dunham (10.1016/j.mcpro.2021.100081_bib128) 2009; 48 Ma (10.1016/j.mcpro.2021.100081_bib83) 1994; 372 Laine (10.1016/j.mcpro.2021.100081_bib88) 1985; 151 Kalsheker (10.1016/j.mcpro.2021.100081_bib81) 1996; 28 Marksteiner (10.1016/j.mcpro.2021.100081_bib115) 2002; 18 Imre (10.1016/j.mcpro.2021.100081_bib68) 2008; 71 Morawski (10.1016/j.mcpro.2021.100081_bib108) 2010; 169 Viapiano (10.1016/j.mcpro.2021.100081_bib116) 2003; 278 Deeb (10.1016/j.mcpro.2021.100081_bib29) 2014; 13 Segal (10.1016/j.mcpro.2021.100081_bib1) 1993; 16 Mysling (10.1016/j.mcpro.2021.100081_bib47) 2010; 82 Lee (10.1016/j.mcpro.2021.100081_bib34) 2016; 15 Pinho (10.1016/j.mcpro.2021.100081_bib10) 2015; 15 Chen (10.1016/j.mcpro.2021.100081_bib38) 2018; 143 Padmanabhan (10.1016/j.mcpro.2021.100081_bib87) 2006; 129 Ohsawa (10.1016/j.mcpro.2021.100081_bib120) 2001; 76 Balog (10.1016/j.mcpro.2021.100081_bib74) 2012; 11 Zhong (10.1016/j.mcpro.2021.100081_bib14) 2015; 87 Chen (10.1016/j.mcpro.2021.100081_bib12) 2018; 42 Zhang (10.1016/j.mcpro.2021.100081_bib24) 2016; 15 Clerc (10.1016/j.mcpro.2021.100081_bib121) 2016; 33 Guldbrandsen (10.1016/j.mcpro.2021.100081_bib8) 2014; 13 Parnetti (10.1016/j.mcpro.2021.100081_bib133) 2009; 34 He (10.1016/j.mcpro.2021.100081_bib146) 2008 Chen (10.1016/j.mcpro.2021.100081_bib11) 2017; 409 Apweiler (10.1016/j.mcpro.2021.100081_bib35) 1999; 1473 Ohtsubo (10.1016/j.mcpro.2021.100081_bib9) 2006; 126 Bern (10.1016/j.mcpro.2021.100081_bib32) 2012; 40 Ondacova (10.1016/j.mcpro.2021.100081_bib112) 2016; 10 Wildsmith (10.1016/j.mcpro.2021.100081_bib126) 2014; 9 May (10.1016/j.mcpro.2021.100081_bib152) 2003; 278 Thaysen-Andersen (10.1016/j.mcpro.2021.100081_bib46) 2013; 3 Palmigiano (10.1016/j.mcpro.2021.100081_bib20) 2016; 131 Botella-Lopez (10.1016/j.mcpro.2021.100081_bib149) 2006; 103 Zhu (10.1016/j.mcpro.2021.100081_bib39) 2018; 18 Faid (10.1016/j.mcpro.2021.100081_bib132) 2006; 16 Chen (10.1016/j.mcpro.2021.100081_bib13) 2019; 118 Zielinska (10.1016/j.mcpro.2021.100081_bib26) 2010; 141 Frese (10.1016/j.mcpro.2021.100081_bib48) 2013; 12 Frese (10.1016/j.mcpro.2021.100081_bib49) 2012; 84 Yagi (10.1016/j.mcpro.2021.100081_bib71) 2012; 287 Riedl (10.1016/j.mcpro.2021.100081_bib99) 2010; 59 Roth (10.1016/j.mcpro.2021.100081_bib59) 2002; 102 McComb (10.1016/j.mcpro.2021.100081_bib2) 1983; 59 Baycin-Hizal (10.1016/j.mcpro.2021.100081_bib113) 2014; 453 Wang (10.1016/j.mcpro.2021.100081_bib31) 2016; 15 Zhong (10.1016/j.mcpro.2021.100081_bib102) 2020; 92 Marino (10.1016/j.mcpro.2021.100081_bib50) 2015; 137 Arvanitis (10.1016/j.mcpro.2021.100081_bib93) 2008; 22 Teufel (10.1016/j.mcpro.2021.100081_bib97) 2003; 278 Kendziorski (10.1016/j.mcpro.2021.100081_bib80) 2005; 102 Dennis (10.1016/j.mcpro.2021.100081_bib57) 2003; 4 Thaysen-Andersen (10.1016/j.mcpro.2021.100081_bib78) 2016; 15 Svensson (10.1016/j.mcpro.2021.100081_bib109) 2011; 50 Eggert (10.1016/j.mcpro.2021.100081_bib143) 2004; 279 Ajit (10.1016/j.mcpro.2021.100081_bib77) 2009 Sethi (10.1016/j.mcpro.2021.100081_bib73) 2013; 13 Kitagishi (10.1016/j.mcpro.2021.100081_bib148) 2014; 6 Glover (10.1016/j.mcpro.2021.100081_bib42) 2018; 427 Kobayashi (10.1016/j.mcpro.2021.100081_bib62) 2002; 51 Watanabe (10.1016/j.mcpro.2021.100081_bib110) 2004; 18 Liu (10.1016/j.mcpro.2021.100081_bib55) 2017; 8 Huang (10.1016/j.mcpro.2021.100081_bib40) 2019; 91 Crehan (10.1016/j.mcpro.2021.100081_bib139) 2012; 2012 Yuzwa (10.1016/j.mcpro.2021.100081_bib19) 2012; 8 Zhang (10.1016/j.mcpro.2021.100081_bib36) 2015; 44 Fournier (10.1016/j.mcpro.2021.100081_bib66) 2000; 1482 Ajmo (10.1016/j.mcpro.2021.100081_bib117) 2010; 113 Kaden (10.1016/j.mcpro.2021.100081_bib144) 2009; 122 Taniguchi (10.1016/j.mcpro.2021.100081_bib64) 2017; 292 Dente (10.1016/j.mcpro.2021.100081_bib67) 1988; 2 Bruggink (10.1016/j.mcpro.2021.100081_bib145) 2015; 134 Kristinsson (10.1016/j.mcpro.2021.100081_bib135) 2012; 8 Diz (10.1016/j.mcpro.2021.100081_bib79) 2009; 30 Hansson (10.1016/j.mcpro.2021.100081_bib140) 2009; 16 Shinohara (10.1016/j.mcpro.2021.100081_bib151) 2017; 58 Yin (10.1016/j.mcpro.2021.100081_bib127) 2009; 1265 |
| References_xml | – volume: 17 start-page: 1125 year: 2020 end-page: 1132 ident: bib56 article-title: Fast and comprehensive N-and O-glycoproteomics analysis with MSFragger-Glyco publication-title: Nat. Methods – volume: 19 start-page: 3452 year: 2020 end-page: 3466 ident: bib41 article-title: Glycopeptide biomarkers in serum haptoglobin for hepatocellular carcinoma detection in patients with non-alcoholic steatohepatitis publication-title: J. Proteome Res. – volume: 1265 start-page: 158 year: 2009 end-page: 170 ident: bib127 article-title: Neuronal pentraxin receptor in cerebrospinal fluid as a potential biomarker for neurodegenerative diseases publication-title: Brain Res. – volume: 5 start-page: 837 year: 2014 end-page: 847 ident: bib136 article-title: Haptoglobin interacts with apolipoprotein E and beta-amyloid and influences their crosstalk publication-title: ACS Chem. Neurosci. – volume: 15 start-page: 2960 year: 2016 end-page: 2968 ident: bib24 article-title: Evaluation of different N-glycopeptide enrichment methods for N-glycosylation sites mapping in mouse brain publication-title: J. Proteome Res. – volume: 58 start-page: 1267 year: 2017 end-page: 1281 ident: bib151 article-title: Role of LRP1 in the pathogenesis of Alzheimer's disease: Evidence from clinical and preclinical studies publication-title: J. Lipid Res. – volume: 1 start-page: 805 year: 2007 end-page: 819 ident: bib5 article-title: Proteomics of human cerebrospinal fluid–the good, the bad, and the ugly publication-title: Proteomics Clin. Appl. – volume: 12 start-page: 1520 year: 2013 end-page: 1525 ident: bib48 article-title: Unambiguous phosphosite localization using electron-transfer/higher-energy collision dissociation (EThcD) publication-title: J. Proteome Res. – volume: 13 start-page: 277 year: 2013 end-page: 288 ident: bib73 article-title: Comparative N-glycan profiling of colorectal cancer cell lines reveals unique bisecting GlcNAc and α-2, 3-linked sialic acid determinants are associated with membrane proteins of the more metastatic/aggressive cell lines publication-title: J. Proteome Res. – volume: 16 start-page: 389 year: 2009 end-page: 397 ident: bib140 article-title: Reduced levels of amyloid-β-binding proteins in cerebrospinal fluid from Alzheimer's disease patients publication-title: J. Alzheimers Dis. – volume: 20 start-page: S1 year: 2010 ident: bib153 article-title: Role of selenoprotein P in Alzheimer's disease publication-title: Ethn. Dis. – volume: 409 start-page: 4437 year: 2017 end-page: 4447 ident: bib11 article-title: Development of a hydrophilic interaction liquid chromatography coupled with matrix-assisted laser desorption/ionization-mass spectrometric imaging platform for N-glycan relative quantitation using stable-isotope labeled hydrazide reagents publication-title: Anal. Bioanal. Chem. – volume: 40 year: 2012 ident: bib32 article-title: Byonic: Advanced peptide and protein identification software publication-title: Curr. Protoc. Bioinformatics – volume: 102 start-page: 285 year: 2002 end-page: 304 ident: bib59 article-title: Protein N-glycosylation along the secretory pathway: Relationship to organelle topography and function, protein quality control, and cell interactions publication-title: Chem. Rev. – volume: 358 start-page: 66 year: 2007 end-page: 72 ident: bib147 article-title: PI3K is negatively regulated by PIK3IP1, a novel p110 interacting protein publication-title: Biochem. Biophys. Res. Commun. – volume: 34 start-page: 484 year: 2009 end-page: 486 ident: bib133 article-title: Cerebrospinal fluid beta-glucocerebrosidase activity is reduced in dementia with Lewy bodies publication-title: Neurobiol. Dis. – volume: 10 start-page: 175 year: 2016 end-page: 184 ident: bib112 article-title: Modulation of Cav3. 2 T-type calcium channel permeability by asparagine-linked glycosylation publication-title: Channels – volume: 125 start-page: 2478 year: 2012 end-page: 2485 ident: bib104 article-title: N-glycosylation alters cadherin-mediated intercellular binding kinetics publication-title: J. Cell Sci. – volume: 87 start-page: 6527 year: 2015 end-page: 6534 ident: bib14 article-title: Capillary electrophoresis-electrospray ionization-mass spectrometry for quantitative analysis of glycans labeled with multiplex carbonyl-reactive tandem mass tags publication-title: Anal. Chem. – volume: 348 start-page: 259 year: 2006 end-page: 268 ident: bib134 article-title: Site-specific N-glycosylation analysis of human plasma ceruloplasmin using liquid chromatography with electrospray ionization tandem mass spectrometry publication-title: Anal. Biochem. – volume: 292 start-page: 11079 year: 2017 end-page: 11090 ident: bib64 article-title: N-glycosylation affects the stability and barrier function of the MUC16 mucin publication-title: J. Biol. Chem – volume: 278 start-page: 33239 year: 2003 end-page: 33247 ident: bib116 article-title: A novel membrane-associated glycovariant of BEHAB/brevican is up-regulated during rat brain development and in a rat model of invasive glioma publication-title: J. Biol. Chem. – volume: 35 start-page: 2341 year: 2012 end-page: 2372 ident: bib37 article-title: Glycopeptide enrichment and separation for protein glycosylation analysis publication-title: J. Sep. Sci. – volume: 26 start-page: 117 year: 2008 end-page: 122 ident: bib125 article-title: Sugar chains of cerebrospinal fluid transferrin as a new biological marker of Alzheimer's disease publication-title: Dement. Geriatr. Cogn. Disord. – volume: 134 start-page: 1152 year: 2015 end-page: 1162 ident: bib145 article-title: Dickkopf-related protein 3 is a potential Aβ-associated protein in Alzheimer's Disease publication-title: J. Neurochem. – volume: 118 start-page: 880 year: 2019 end-page: 892 ident: bib13 article-title: Recent advances in mass spectrometry (MS)-based glycoproteomics in complex biological samples publication-title: Trac Trends Anal. Chem. – volume: 2 start-page: 259 year: 1988 end-page: 266 ident: bib67 article-title: Expression of human alpha 1-acid glycoprotein genes in cultured cells and in transgenic mice publication-title: Genes Dev. – volume: 372 start-page: 92 year: 1994 end-page: 94 ident: bib83 article-title: Amyloid-associated proteins α1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer β-protein into filaments publication-title: Nature – volume: 126 start-page: 855 year: 2006 end-page: 867 ident: bib9 article-title: Glycosylation in cellular mechanisms of health and disease publication-title: Cell – volume: 21 start-page: 1444 year: 2001 end-page: 1451 ident: bib85 article-title: α-1-Antichymotrypsin promotes β-sheet amyloid plaque deposition in a transgenic mouse model of Alzheimer's disease publication-title: J. Neurosci. – volume: 2012 start-page: 983640 year: 2012 ident: bib139 article-title: Microglia, Alzheimer's disease, and complement publication-title: Int. J. Alzheimers Dis. – volume: 20 start-page: 7505 year: 2000 end-page: 7509 ident: bib123 article-title: Deficiency of complement defense protein CD59 may contribute to neurodegeneration in Alzheimer's disease publication-title: J. Neurosci. – volume: 278 start-page: 6521 year: 2003 end-page: 6531 ident: bib97 article-title: Sequence identification and characterization of human carnosinase and a closely related non-specific dipeptidase publication-title: J. Biol. Chem. – volume: 16 start-page: 440 year: 2006 end-page: 461 ident: bib132 article-title: Site-specific glycosylation analysis of the bovine lysosomal α-mannosidase publication-title: Glycobiology – volume: 278 start-page: 37386 year: 2003 end-page: 37392 ident: bib152 article-title: Differential glycosylation regulates processing of lipoprotein receptors by γ-secretase publication-title: J. Biol. Chem. – volume: 1482 start-page: 157 year: 2000 end-page: 171 ident: bib66 article-title: Alpha-1-acid glycoprotein publication-title: Biochim. Biophys. Acta Protein Struct. Mol. Enzymol. – volume: 13 start-page: 3152 year: 2014 end-page: 3163 ident: bib8 article-title: In-depth characterization of the cerebrospinal fluid (CSF) proteome displayed through the CSF proteome resource (CSF-PR) publication-title: Mol. Cell. Proteomics – volume: 131 start-page: 29 year: 2016 end-page: 37 ident: bib20 article-title: CSF N-glycoproteomics for early diagnosis in Alzheimer's disease publication-title: J. Proteomics – volume: 281 start-page: 46 year: 2014 end-page: 62 ident: bib16 article-title: The role of protein glycosylation in Alzheimer disease publication-title: FEBS J. – volume: 7 start-page: 378 year: 2013 end-page: 382 ident: bib111 article-title: Sortilin, a novel APOE receptor implicated in Alzheimer disease publication-title: Prion – volume: 22 start-page: 39 year: 2006 end-page: 64 ident: bib6 article-title: Identification of disease markers in human cerebrospinal fluid using lipidomic and proteomic methods publication-title: Dis. Markers – volume: 4 start-page: 1537 year: 2004 end-page: 1550 ident: bib61 article-title: Annotation of post-translational modifications in the Swiss-Prot knowledge base publication-title: Proteomics – volume: 6 start-page: 809 year: 2009 end-page: 811 ident: bib21 article-title: Enrichment of glycopeptides for glycan structure and attachment site identification publication-title: Nat. Methods – volume: 91 start-page: 11589 year: 2019 end-page: 11597 ident: bib40 article-title: Dual-functional titanium (IV) immobilized metal affinity chromatography approach for enabling large-scale profiling of protein mannose-6-phosphate glycosylation and revealing its predominant substrates publication-title: Anal. Chem. – volume: 82 start-page: 5598 year: 2010 end-page: 5609 ident: bib47 article-title: Utilizing ion-pairing hydrophilic interaction chromatography solid phase extraction for efficient glycopeptide enrichment in glycoproteomics publication-title: Anal. Chem. – volume: 11 start-page: 483 year: 2019 ident: bib53 article-title: A strategy for discovery and verification of candidate biomarkers in cerebrospinal fluid of preclinical Alzheimer’s disease publication-title: Front. Mol. Neurosci. – volume: 169 start-page: 1347 year: 2010 end-page: 1363 ident: bib108 article-title: Neurons associated with aggrecan-based perineuronal nets are protected against tau pathology in subcortical regions in Alzheimer's disease publication-title: Neuroscience – volume: 20 start-page: 1273 year: 2004 end-page: 1279 ident: bib72 article-title: Glycosylation profiles of the human colorectal cancer A33 antigen naturally expressed in the human colorectal cancer cell line SW1222 and expressed as recombinant protein in different insect cell lines publication-title: Biotechnol. Prog. – volume: 38 start-page: 567 year: 2014 end-page: 579 ident: bib142 article-title: Blood plasma IgG Fc glycans are significantly altered in Alzheimer's disease and progressive mild cognitive impairment publication-title: J. Alzheimers Dis. – volume: 143 start-page: 2508 year: 2018 end-page: 2519 ident: bib38 article-title: Site-specific characterization and quantitation of N-glycopeptides in PKM2 knockout breast cancer cells using DiLeu isobaric tags enabled by electron-transfer/higher-energy collision dissociation (EThcD) publication-title: Analyst – volume: 1856 start-page: 211 year: 2015 end-page: 225 ident: bib65 article-title: Pathobiological implications of mucin glycans in cancer: Sweet poison and novel targets publication-title: Biochim. Biophys. Acta Rev. Cancer – volume: 344 start-page: 1391 year: 2009 end-page: 1396 ident: bib70 article-title: Paucimannose N-glycans in Caenorhabditis elegans and Drosophila melanogaster publication-title: Carbohydr. Res. – volume: 92 start-page: 11119 year: 2020 end-page: 11126 ident: bib102 article-title: Mass defect-based DiLeu tagging for multiplexed data-independent acquisition publication-title: Anal. Chem. – volume: 151 start-page: 327 year: 1985 end-page: 331 ident: bib88 article-title: Human serum α1-antichymotrypsin is an inhibitor of pancreatic elastases publication-title: FEBS J. – volume: 33 start-page: 309 year: 2016 end-page: 343 ident: bib121 article-title: Human plasma protein N publication-title: Glycoconj. J. – volume: 55 start-page: 465 year: 2015 end-page: 487 ident: bib95 article-title: Eph receptors and ephrins: Therapeutic opportunities publication-title: Annu. Rev. Pharmacol. Toxicol. – volume: 118 start-page: 167 year: 2009 end-page: 179 ident: bib130 article-title: Synaptic degeneration in Alzheimer's disease publication-title: Acta Neuropathol. – volume: 275 start-page: 39096 year: 2000 end-page: 39102 ident: bib107 article-title: Age-related changes in aggrecan glycosylation affect cleavage by aggrecanase publication-title: J. Biol. Chem. – volume: 29 start-page: 565 year: 2015 end-page: 575 ident: bib119 article-title: Genetic ablation of N-linked glycosylation reveals two key folding pathways for R345W fibulin-3, a secreted protein associated with retinal degeneration publication-title: FASEB J. – volume: 19 start-page: 634 year: 2019 end-page: 643 ident: bib43 article-title: Signature-ion-triggered mass spectrometry approach enabled discovery of N-and O-linked glycosylated neuropeptides in the Crustacean nervous system publication-title: J. Proteome Res. – volume: 84 start-page: 9668 year: 2012 end-page: 9673 ident: bib49 article-title: Toward full peptide sequence coverage by dual fragmentation combining electron-transfer and higher-energy collision dissociation tandem mass spectrometry publication-title: Anal. Chem. – volume: 101 start-page: 10804 year: 2004 end-page: 10809 ident: bib18 article-title: O-GlcNAcylation regulates phosphorylation of tau: A mechanism involved in Alzheimer's disease publication-title: Proc. Natl. Acad. Sci. U. S. A. – volume: 279 start-page: 18146 year: 2004 end-page: 18156 ident: bib143 article-title: The proteolytic processing of the amyloid precursor protein gene family members APLP-1 and APLP-2 involves α-, β-, γ-, and ε-like cleavages modulation of APLP-1 processing by N-glycosylation publication-title: J. Biol. Chem. – volume: 115 start-page: 842 year: 2013 end-page: 848 ident: bib25 article-title: Brush polymer modified and lectin immobilized core–shell microparticle for highly efficient glycoprotein/glycopeptide enrichment publication-title: Talanta – volume: 22 start-page: 416 year: 2008 end-page: 429 ident: bib93 article-title: Eph/ephrin signaling: Networks publication-title: Genes Dev. – volume: 427 start-page: 35 year: 2018 end-page: 42 ident: bib42 article-title: Characterization of intact sialylated glycopeptides and phosphorylated glycopeptides from IMAC enriched samples by EThcD fragmentation: Toward combining phosphoproteomics and glycoproteomics publication-title: Int. J. Mass Spectrom. – volume: 15 start-page: 3904 year: 2016 end-page: 3915 ident: bib34 article-title: Toward automated N-glycopeptide identification in glycoproteomics publication-title: J. Proteome Res. – volume: 287 start-page: 24356 year: 2012 end-page: 24364 ident: bib71 article-title: Lewis X-carrying N-glycans regulate the proliferation of mouse embryonic neural stem cells via the Notch signaling pathway publication-title: J. Biol. Chem. – volume: 87 start-page: 1646 year: 2014 end-page: 1654 ident: bib100 article-title: High-resolution enabled 12-plex DiLeu isobaric tags for quantitative proteomics publication-title: Anal. Chem. – volume: 9 start-page: 293 year: 2006 end-page: 348 ident: bib4 article-title: Detection of biomarkers with a multiplex quantitative proteomic platform in cerebrospinal fluid of patients with neurodegenerative disorders publication-title: J. Alzheimers Dis. – volume: 42 start-page: 1 year: 2018 end-page: 8 ident: bib12 article-title: Recent advances in ion mobility–mass spectrometry for improved structural characterization of glycans and glycoconjugates publication-title: Curr. Opin. Chem. Biol. – volume: 14 start-page: 493 year: 2009 end-page: 501 ident: bib122 article-title: Proteomics-derived cerebrospinal fluid markers of autopsy-confirmed Alzheimer's disease publication-title: Biomarkers – volume: 50 start-page: 9377 year: 2011 end-page: 9387 ident: bib109 article-title: The structural role of N-linked glycans on human glypican-1 publication-title: Biochemistry – year: 2013 ident: bib98 article-title: Biochemical Biomarkers in Alzheimer’s Disease – volume: 19 start-page: 2606 year: 2020 end-page: 2616 ident: bib7 article-title: Isobaric labeling strategy utilizing 4-plex N, N-dimethyl leucine (DiLeu) tags reveals proteomic changes induced by chemotherapy in cerebrospinal fluid of children with B-cell acute lymphoblastic leukemia publication-title: J. Proteome Res. – volume: 157 start-page: 2003 year: 2000 end-page: 2010 ident: bib86 article-title: Astroglial expression of human α 1-antichymotrypsin enhances Alzheimer-like pathology in amyloid protein precursor transgenic mice publication-title: Am. J. Pathol. – volume: 45 start-page: 314 year: 2012 end-page: 326 ident: bib114 article-title: The role of clusterin in Alzheimer's disease: Pathways, pathogenesis, and therapy publication-title: Mol. Neurobiol. – volume: 6 start-page: 359 year: 2009 end-page: 362 ident: bib27 article-title: Universal sample preparation method for proteome analysis publication-title: Nat. Methods – volume: 9 start-page: 22 year: 2014 ident: bib126 article-title: Identification of longitudinally dynamic biomarkers in Alzheimer's disease cerebrospinal fluid by targeted proteomics publication-title: Mol. Neurodegener. – volume: 15 start-page: 2462 year: 2016 end-page: 2475 ident: bib31 article-title: A novel quantitative mass spectrometry platform for determining protein O-GlcNAcylation dynamics publication-title: Mol. Cell. Proteomics – volume: 28 start-page: 961 year: 1996 end-page: 964 ident: bib81 article-title: α1-antichymotrypsin publication-title: Int. J. Biochem. Cell Biol. – volume: 17 start-page: 781 year: 2013 end-page: 794 ident: bib150 article-title: Targeting ApoE4/ApoE receptor LRP1 in Alzheimer's disease publication-title: Expert Opin. Ther. Targets – volume: 34 start-page: 911 year: 1988 end-page: 915 ident: bib89 article-title: Alpha 1-antichymotrypsin microheterogeneity in crossed immunoaffinoelectrophoresis with free concanavalin A: A useful diagnostic tool in inflammatory syndrome publication-title: Clin. Chem. – volume: 17 start-page: 240 year: 2016 end-page: 257 ident: bib91 article-title: Mechanisms of ephrin-Eph signalling in development, physiology and disease publication-title: Nat. Rev. Mol. Cel. Biol. – volume: 111 start-page: 313 year: 2009 end-page: 318 ident: bib3 article-title: A modern approach to CSF analysis: Pathophysiology, clinical application, proof of concept and laboratory reporting publication-title: Clin. Neurol. Neurosurg. – volume: 72 start-page: 1946 year: 2004 end-page: 1955 ident: bib138 article-title: N-linked glycosylation is required for C1 inhibitor-mediated protection from endotoxin shock in mice publication-title: Infect. Immun. – volume: 29 start-page: 79 year: 2010 end-page: 125 ident: bib15 article-title: Glycoproteomics in neurodegenerative diseases publication-title: Mass Spectrom. Rev. – volume: 7 start-page: S6 year: 2010 ident: bib92 article-title: Altered glycosylation profile of purified plasma ACT from Alzheimer’s disease publication-title: Immun. Ageing – volume: 13 start-page: 6176 year: 2014 end-page: 6186 ident: bib44 article-title: Off-line high-pH reversed-phase fractionation for in-depth phosphoproteomics publication-title: J. Proteome Res. – volume: 102 start-page: 4252 year: 2005 end-page: 4257 ident: bib80 article-title: On the utility of pooling biological samples in microarray experiments publication-title: Proc. Natl. Acad. Sci. U. S. A. – volume: 48 start-page: 10286 year: 2009 end-page: 10297 ident: bib128 article-title: GPR37 surface expression enhancement via N-terminal truncation or protein−protein interactions publication-title: Biochemistry – volume: 122 start-page: 368 year: 2009 end-page: 377 ident: bib144 article-title: Subcellular localization and dimerization of APLP1 are strikingly different from APP and APLP2 publication-title: J. Cell Sci. – volume: 30 start-page: 2967 year: 2009 end-page: 2975 ident: bib79 article-title: The consequences of sample pooling in proteomics: An empirical study publication-title: Electrophoresis – volume: 47 start-page: 1327 year: 2012 end-page: 1332 ident: bib28 article-title: Investigation and reduction of sub-microgram peptide loss using molecular weight cut-off fractionation prior to mass spectrometric analysis publication-title: J. Mass Spectrom. – volume: 24 start-page: 606 year: 2012 end-page: 611 ident: bib94 article-title: Eph receptors at synapses: Implications in neurodegenerative diseases publication-title: Cell. Signal. – volume: 29 start-page: 461 year: 2015 end-page: 473 ident: bib22 article-title: Evaluation of a combined glycomics and glycoproteomics approach for studying the major glycoproteins present in biofluids: Application to cerebrospinal fluid publication-title: Rapid Commun. Mass Spectrom. – volume: 18 start-page: 359 year: 2018 end-page: 371 ident: bib39 article-title: Differential quantitative determination of site-specific intact N-glycopeptides in serum haptoglobin between hepatocellular carcinoma and cirrhosis using LC-EThcD-MS/MS publication-title: J. Proteome Res. – year: 2009 ident: bib77 article-title: Essentials of Glycobiology – volume: 16 start-page: 407 year: 2005 ident: bib45 article-title: Selective isolation of glycoproteins and glycopeptides for MALDI-TOF MS detection supported by magnetic particles publication-title: J. Biomol. Tech. JBT – volume: 4 start-page: R60 year: 2003 ident: bib57 article-title: David: Database for annotation, visualization, and integrated discovery publication-title: Genome Biol. – volume: 46 start-page: 11 year: 2012 end-page: 19 ident: bib118 article-title: Regulation of complement factor H (CFH) by multiple miRNAs in Alzheimer's disease (AD) brain publication-title: Mol. Neurobiol. – volume: 197 start-page: 209 year: 1991 end-page: 215 ident: bib90 article-title: Structure determination of the glycans of human-serum α1-antichymotrypsin using 1H-NMR spectroscopy and deglycosylation by N-glycanase publication-title: FEBS J. – volume: 15 start-page: 540 year: 2015 ident: bib10 article-title: Glycosylation in cancer: Mechanisms and clinical implications publication-title: Nat. Rev. Cancer – volume: 290 start-page: 8789 year: 2015 end-page: 8802 ident: bib76 article-title: Human neutrophils secrete bioactive paucimannosidic proteins from azurophilic granules into pathogen-infected sputum publication-title: J. Biol. Chem. – volume: 1585 start-page: 1 year: 2014 end-page: 12 ident: bib129 article-title: The protective role of prosaposin and its receptors in the nervous system publication-title: Brain Res. – volume: 23 start-page: 2078 year: 2006 end-page: 2086 ident: bib17 article-title: Concurrent alterations of O-GlcNAcylation and phosphorylation of tau in mouse brains during fasting publication-title: Eur. J. Neurosci. – volume: 46 start-page: 542 year: 2012 end-page: 548 ident: bib30 article-title: Mapping N-glycosylation sites across seven evolutionarily distant species reveals a divergent substrate proteome despite a common core machinery publication-title: Mol. Cell – volume: 17 start-page: 773 year: 1996 end-page: 780 ident: bib84 article-title: Alzheimer Aβ neurotoxicity: Promotion by antichymotrypsin, apoE4; inhibition by Aβ-related peptides publication-title: Neurobiol. Aging – volume: 8 start-page: 515 year: 2012 ident: bib135 article-title: Ceruloplasmin and iron in Alzheimer's disease and Parkinson's disease: A synopsis of recent studies publication-title: Neuropsychiatr. Dis. Treat. – volume: 103 start-page: 5573 year: 2006 end-page: 5578 ident: bib149 article-title: Reelin expression and glycosylation patterns are altered in Alzheimer's disease publication-title: Proc. Natl. Acad. Sci. U. S. A. – volume: 3 start-page: 22683 year: 2013 end-page: 22705 ident: bib46 article-title: Structural analysis of glycoprotein sialylation–part I: Pre-LC-MS analytical strategies publication-title: Rsc Adv. – volume: 44 start-page: 8260 year: 2015 end-page: 8287 ident: bib36 article-title: Fishing the PTM proteome with chemical approaches using functional solid phases publication-title: Chem. Soc. Rev. – volume: 113 start-page: 784 year: 2010 end-page: 795 ident: bib117 article-title: Abnormal post-translational and extracellular processing of brevican in plaque-bearing mice over-expressing APPsw publication-title: J. Neurochem. – volume: 32 start-page: D115 year: 2004 end-page: D119 ident: bib60 article-title: UniProt: The universal protein knowledgebase publication-title: Nucleic Acids Res – volume: 76 start-page: 1411 year: 2001 end-page: 1420 ident: bib120 article-title: Fibulin-1 binds the amino-terminal head of β-amyloid precursor protein and modulates its physiological function publication-title: J. Neurochem. – volume: 272 start-page: 7229 year: 1997 end-page: 7244 ident: bib124 article-title: The glycosylation of the complement regulatory protein, human erythrocyte CD59 publication-title: J. Biol. Chem. – volume: 453 start-page: 243 year: 2014 end-page: 253 ident: bib113 article-title: Physiologic and pathophysiologic consequences of altered sialylation and glycosylation on ion channel function publication-title: Biochem. Biophys. Res. Commun. – volume: 27 start-page: 53 year: 1991 end-page: 70 ident: bib131 article-title: Glycosylation of neural cell adhesion molecules of the immunoglobulin superfamily publication-title: APMIS Suppl. – volume: 10 start-page: 1225 year: 2016 end-page: 1241 ident: bib23 article-title: Label-free quantitative comparison of cerebrospinal fluid glycoproteins and endogenous peptides in subjects with Alzheimer's disease, mild cognitive impairment, and healthy individuals publication-title: Proteomics Clin. Appl. – volume: 137 start-page: 10922 year: 2015 end-page: 10925 ident: bib50 article-title: Extended O-GlcNAc on HLA class-I-bound peptides publication-title: J. Am. Chem. Soc. – volume: 71 start-page: 186 year: 2008 end-page: 197 ident: bib68 article-title: Mass spectrometric and linear discriminant analysis of N-glycans of human serum alpha-1-acid glycoprotein in cancer patients and healthy individuals publication-title: J. Proteomics – volume: 288 start-page: 18448 year: 2013 end-page: 18457 ident: bib96 article-title: Biological and structural characterization of glycosylation on ephrin-A1, a preferred ligand for EphA2 receptor tyrosine kinase publication-title: J. Biol. Chem. – volume: 1473 start-page: 4 year: 1999 end-page: 8 ident: bib35 article-title: On the frequency of protein glycosylation, as deduced from analysis of the SWISS-PROT database publication-title: Biochim. Biophys. Acta – volume: 8 start-page: 393 year: 2012 end-page: 399 ident: bib19 article-title: Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation publication-title: Nat. Chem. Biol. – volume: 16 start-page: 1 year: 2019 end-page: 11 ident: bib54 article-title: N-GlycositeAtlas: A database resource for mass spectrometry-based human N-linked glycoprotein and glycosylation site mapping publication-title: Clin. Proteomics – volume: 13 start-page: 240 year: 2014 end-page: 251 ident: bib29 article-title: N-linked glycosylation enrichment for in-depth cell surface proteomics of diffuse large B-cell lymphoma subtypes publication-title: Mol. Cell. Proteomics – volume: 11 start-page: 571 year: 2012 end-page: 585 ident: bib74 article-title: N-glycosylation of colorectal cancer tissues a liquid chromatography and mass spectrometry-based investigation publication-title: Mol. Cell. Proteomics – year: 2008 ident: bib146 article-title: Role of PIK3IP1, a negative PI3K regulator publication-title: Hepatic Tumorigenesis and Metabolism – volume: 6 start-page: 35 year: 2014 ident: bib148 article-title: Dietary regulation of PI3K/AKT/GSK-3β pathway in Alzheimer's disease publication-title: Alzheimers Res. Ther. – volume: 22 start-page: 73 year: 2006 end-page: 81 ident: bib141 article-title: Prostaglandin D synthase isoforms from cerebrospinal fluid vary with brain pathology publication-title: Dis. Markers – volume: 129 start-page: 3020 year: 2006 end-page: 3034 ident: bib87 article-title: Alpha1-antichymotrypsin, an inflammatory protein overexpressed in Alzheimer's disease brain, induces tau phosphorylation in neurons publication-title: Brain – volume: 8 start-page: 1 year: 2017 end-page: 14 ident: bib55 article-title: pGlyco 2.0 enables precision N-glycoproteomics with comprehensive quality control and one-step mass spectrometry for intact glycopeptide identification publication-title: Nat. Commun. – volume: 9 start-page: 112 year: 1995 end-page: 118 ident: bib82 article-title: Acute phase reactant [alpha] 1Antichymotrypsin is increased in cerebrospinal fluid and serum of patients with probable Alzheimer disease publication-title: Alzheimer Dis. Assoc. Disord. – volume: 28 start-page: 1751 year: 2017 end-page: 1764 ident: bib51 article-title: Electron-transfer/higher-energy collision dissociation (EThcD)-Enabled intact glycopeptide/glycoproteome characterization publication-title: J. Am. Soc. Mass Spectrom. – volume: 4 start-page: 2070 year: 2005 end-page: 2080 ident: bib52 article-title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry publication-title: J. Proteome Res. – volume: 18 start-page: 1013 year: 2004 end-page: 1015 ident: bib110 article-title: Glypican-1 as an Aβ binding HSPG in the human brain: Its localization in DIG domains and possible roles in the pathogenesis of Alzheimer's disease publication-title: FASEB J. – volume: 8 start-page: 1534 year: 2005 end-page: 1541 ident: bib106 article-title: Cbln1 is essential for synaptic integrity and plasticity in the cerebellum publication-title: Nat. Neurosci. – volume: 59 start-page: 1984 year: 2010 end-page: 1990 ident: bib99 article-title: N-glycosylation of carnosinase influences protein secretion and enzyme activity: implications for hyperglycemia publication-title: Diabetes – volume: 59 start-page: 369 year: 1983 end-page: 383 ident: bib2 article-title: Recent research into the nature of cerebrospinal fluid formation and absorption publication-title: J. Neurosurg. – volume: 16 start-page: 623 year: 2006 end-page: 634 ident: bib63 article-title: N-Glycosylation of the MUC1 mucin in epithelial cells and secretions publication-title: Glycobiology – volume: 22 start-page: 1465 year: 2012 end-page: 1479 ident: bib75 article-title: Comparative structural analysis of the glycosylation of salivary and buccal cell proteins: Innate protection against infection by Candida albicans publication-title: Glycobiology – volume: 51 start-page: 169 year: 2002 end-page: 176 ident: bib62 article-title: Distribution and partial characterisation of IgG Fc binding protein in various mucin producing cells and body fluids publication-title: Gut – volume: 105 start-page: 975 year: 2020 end-page: 991.e7 ident: bib58 article-title: Deep multilayer brain proteomics identifies molecular networks in Alzheimer’s disease progression publication-title: Neuron – volume: 16 start-page: 617 year: 1993 end-page: 638 ident: bib1 article-title: Extracellular and cerebrospinal fluids publication-title: J. Inherit. Metab. Dis. – volume: 2016 start-page: 6427537 year: 2016 ident: bib103 article-title: Synaptic cell adhesion molecules in Alzheimer's disease publication-title: Neural Plast. – volume: 141 start-page: 897 year: 2010 end-page: 907 ident: bib26 article-title: Precision mapping of an publication-title: Cell – volume: 10 start-page: 5296 year: 2011 end-page: 5301 ident: bib33 article-title: Two-dimensional target decoy strategy for shotgun proteomics publication-title: J. Proteome Res. – volume: 36 start-page: 1057 year: 2015 end-page: 1071 ident: bib105 article-title: Cerebellin 4, a synaptic protein, enhances inhibitory activity and resistance of neurons to amyloid-β toxicity publication-title: Neurobiol. Aging – volume: 91 start-page: 2112 year: 2019 end-page: 2119 ident: bib101 article-title: Hotmaq: A multiplexed absolute quantification method for targeted proteomics publication-title: Anal. Chem. – volume: 15 start-page: 1773 year: 2016 end-page: 1790 ident: bib78 article-title: Maturing glycoproteomics technologies provide unique structural insights into the N-glycoproteome and its regulation in health and disease publication-title: Mol. Cell. Proteomics – volume: 54 start-page: 453 year: 2015 end-page: 457 ident: bib137 article-title: Association between serum haptoglobin and the pathogenesis of Alzheimer's disease publication-title: Intern. Med. – volume: 281 start-page: 12776 year: 2006 end-page: 12785 ident: bib69 article-title: Null mutations in Drosophila N-acetylglucosaminyltransferase I produce defects in locomotion and a reduced life span publication-title: J. Biol. Chem. – volume: 18 start-page: 53 year: 2002 end-page: 63 ident: bib115 article-title: Synaptic proteins in Alzheimer's disease publication-title: J. Mol. Neurosci. – volume: 427 start-page: 35 year: 2018 ident: 10.1016/j.mcpro.2021.100081_bib42 article-title: Characterization of intact sialylated glycopeptides and phosphorylated glycopeptides from IMAC enriched samples by EThcD fragmentation: Toward combining phosphoproteomics and glycoproteomics publication-title: Int. J. Mass Spectrom. doi: 10.1016/j.ijms.2017.09.002 – volume: 46 start-page: 11 year: 2012 ident: 10.1016/j.mcpro.2021.100081_bib118 article-title: Regulation of complement factor H (CFH) by multiple miRNAs in Alzheimer's disease (AD) brain publication-title: Mol. Neurobiol. doi: 10.1007/s12035-012-8234-4 – volume: 47 start-page: 1327 year: 2012 ident: 10.1016/j.mcpro.2021.100081_bib28 article-title: Investigation and reduction of sub-microgram peptide loss using molecular weight cut-off fractionation prior to mass spectrometric analysis publication-title: J. Mass Spectrom. doi: 10.1002/jms.3069 – volume: 15 start-page: 2462 year: 2016 ident: 10.1016/j.mcpro.2021.100081_bib31 article-title: A novel quantitative mass spectrometry platform for determining protein O-GlcNAcylation dynamics publication-title: Mol. Cell. Proteomics doi: 10.1074/mcp.O115.049627 – year: 2013 ident: 10.1016/j.mcpro.2021.100081_bib98 – volume: 118 start-page: 167 year: 2009 ident: 10.1016/j.mcpro.2021.100081_bib130 article-title: Synaptic degeneration in Alzheimer's disease publication-title: Acta Neuropathol. doi: 10.1007/s00401-009-0536-x – volume: 16 start-page: 1 year: 2019 ident: 10.1016/j.mcpro.2021.100081_bib54 article-title: N-GlycositeAtlas: A database resource for mass spectrometry-based human N-linked glycoprotein and glycosylation site mapping publication-title: Clin. Proteomics doi: 10.1186/s12014-019-9254-0 – volume: 87 start-page: 6527 year: 2015 ident: 10.1016/j.mcpro.2021.100081_bib14 article-title: Capillary electrophoresis-electrospray ionization-mass spectrometry for quantitative analysis of glycans labeled with multiplex carbonyl-reactive tandem mass tags publication-title: Anal. Chem. doi: 10.1021/acs.analchem.5b01835 – volume: 27 start-page: 53 year: 1991 ident: 10.1016/j.mcpro.2021.100081_bib131 article-title: Glycosylation of neural cell adhesion molecules of the immunoglobulin superfamily publication-title: APMIS Suppl. – volume: 46 start-page: 542 year: 2012 ident: 10.1016/j.mcpro.2021.100081_bib30 article-title: Mapping N-glycosylation sites across seven evolutionarily distant species reveals a divergent substrate proteome despite a common core machinery publication-title: Mol. Cell doi: 10.1016/j.molcel.2012.04.031 – volume: 2 start-page: 259 year: 1988 ident: 10.1016/j.mcpro.2021.100081_bib67 article-title: Expression of human alpha 1-acid glycoprotein genes in cultured cells and in transgenic mice publication-title: Genes Dev. doi: 10.1101/gad.2.2.259 – volume: 2012 start-page: 983640 year: 2012 ident: 10.1016/j.mcpro.2021.100081_bib139 article-title: Microglia, Alzheimer's disease, and complement publication-title: Int. J. Alzheimers Dis. – volume: 21 start-page: 1444 year: 2001 ident: 10.1016/j.mcpro.2021.100081_bib85 article-title: α-1-Antichymotrypsin promotes β-sheet amyloid plaque deposition in a transgenic mouse model of Alzheimer's disease publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.21-05-01444.2001 – volume: 6 start-page: 809 year: 2009 ident: 10.1016/j.mcpro.2021.100081_bib21 article-title: Enrichment of glycopeptides for glycan structure and attachment site identification publication-title: Nat. Methods doi: 10.1038/nmeth.1392 – volume: 20 start-page: 1273 year: 2004 ident: 10.1016/j.mcpro.2021.100081_bib72 article-title: Glycosylation profiles of the human colorectal cancer A33 antigen naturally expressed in the human colorectal cancer cell line SW1222 and expressed as recombinant protein in different insect cell lines publication-title: Biotechnol. Prog. doi: 10.1021/bp034378n – volume: 129 start-page: 3020 year: 2006 ident: 10.1016/j.mcpro.2021.100081_bib87 article-title: Alpha1-antichymotrypsin, an inflammatory protein overexpressed in Alzheimer's disease brain, induces tau phosphorylation in neurons publication-title: Brain doi: 10.1093/brain/awl255 – volume: 44 start-page: 8260 year: 2015 ident: 10.1016/j.mcpro.2021.100081_bib36 article-title: Fishing the PTM proteome with chemical approaches using functional solid phases publication-title: Chem. Soc. Rev. doi: 10.1039/C4CS00529E – volume: 32 start-page: D115 year: 2004 ident: 10.1016/j.mcpro.2021.100081_bib60 article-title: UniProt: The universal protein knowledgebase publication-title: Nucleic Acids Res doi: 10.1093/nar/gkh131 – volume: 5 start-page: 837 year: 2014 ident: 10.1016/j.mcpro.2021.100081_bib136 article-title: Haptoglobin interacts with apolipoprotein E and beta-amyloid and influences their crosstalk publication-title: ACS Chem. Neurosci. doi: 10.1021/cn500099f – volume: 122 start-page: 368 year: 2009 ident: 10.1016/j.mcpro.2021.100081_bib144 article-title: Subcellular localization and dimerization of APLP1 are strikingly different from APP and APLP2 publication-title: J. Cell Sci. doi: 10.1242/jcs.034058 – volume: 13 start-page: 240 year: 2014 ident: 10.1016/j.mcpro.2021.100081_bib29 article-title: N-linked glycosylation enrichment for in-depth cell surface proteomics of diffuse large B-cell lymphoma subtypes publication-title: Mol. Cell. Proteomics doi: 10.1074/mcp.M113.033977 – volume: 16 start-page: 623 year: 2006 ident: 10.1016/j.mcpro.2021.100081_bib63 article-title: N-Glycosylation of the MUC1 mucin in epithelial cells and secretions publication-title: Glycobiology doi: 10.1093/glycob/cwj110 – volume: 45 start-page: 314 year: 2012 ident: 10.1016/j.mcpro.2021.100081_bib114 article-title: The role of clusterin in Alzheimer's disease: Pathways, pathogenesis, and therapy publication-title: Mol. Neurobiol. doi: 10.1007/s12035-012-8237-1 – volume: 1482 start-page: 157 year: 2000 ident: 10.1016/j.mcpro.2021.100081_bib66 article-title: Alpha-1-acid glycoprotein publication-title: Biochim. Biophys. Acta Protein Struct. Mol. Enzymol. doi: 10.1016/S0167-4838(00)00153-9 – volume: 22 start-page: 73 year: 2006 ident: 10.1016/j.mcpro.2021.100081_bib141 article-title: Prostaglandin D synthase isoforms from cerebrospinal fluid vary with brain pathology publication-title: Dis. Markers doi: 10.1155/2006/241817 – volume: 29 start-page: 79 year: 2010 ident: 10.1016/j.mcpro.2021.100081_bib15 article-title: Glycoproteomics in neurodegenerative diseases publication-title: Mass Spectrom. Rev. doi: 10.1002/mas.20221 – volume: 10 start-page: 5296 year: 2011 ident: 10.1016/j.mcpro.2021.100081_bib33 article-title: Two-dimensional target decoy strategy for shotgun proteomics publication-title: J. Proteome Res. doi: 10.1021/pr200780j – volume: 12 start-page: 1520 year: 2013 ident: 10.1016/j.mcpro.2021.100081_bib48 article-title: Unambiguous phosphosite localization using electron-transfer/higher-energy collision dissociation (EThcD) publication-title: J. Proteome Res. doi: 10.1021/pr301130k – volume: 287 start-page: 24356 year: 2012 ident: 10.1016/j.mcpro.2021.100081_bib71 article-title: Lewis X-carrying N-glycans regulate the proliferation of mouse embryonic neural stem cells via the Notch signaling pathway publication-title: J. Biol. Chem. doi: 10.1074/jbc.M112.365643 – volume: 358 start-page: 66 year: 2007 ident: 10.1016/j.mcpro.2021.100081_bib147 article-title: PI3K is negatively regulated by PIK3IP1, a novel p110 interacting protein publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/j.bbrc.2007.04.096 – volume: 348 start-page: 259 year: 2006 ident: 10.1016/j.mcpro.2021.100081_bib134 article-title: Site-specific N-glycosylation analysis of human plasma ceruloplasmin using liquid chromatography with electrospray ionization tandem mass spectrometry publication-title: Anal. Biochem. doi: 10.1016/j.ab.2005.10.036 – volume: 16 start-page: 407 year: 2005 ident: 10.1016/j.mcpro.2021.100081_bib45 article-title: Selective isolation of glycoproteins and glycopeptides for MALDI-TOF MS detection supported by magnetic particles publication-title: J. Biomol. Tech. JBT – volume: 82 start-page: 5598 year: 2010 ident: 10.1016/j.mcpro.2021.100081_bib47 article-title: Utilizing ion-pairing hydrophilic interaction chromatography solid phase extraction for efficient glycopeptide enrichment in glycoproteomics publication-title: Anal. Chem. doi: 10.1021/ac100530w – volume: 15 start-page: 1773 year: 2016 ident: 10.1016/j.mcpro.2021.100081_bib78 article-title: Maturing glycoproteomics technologies provide unique structural insights into the N-glycoproteome and its regulation in health and disease publication-title: Mol. Cell. Proteomics doi: 10.1074/mcp.O115.057638 – year: 2008 ident: 10.1016/j.mcpro.2021.100081_bib146 article-title: Role of PIK3IP1, a negative PI3K regulator – volume: 126 start-page: 855 year: 2006 ident: 10.1016/j.mcpro.2021.100081_bib9 article-title: Glycosylation in cellular mechanisms of health and disease publication-title: Cell doi: 10.1016/j.cell.2006.08.019 – volume: 18 start-page: 359 year: 2018 ident: 10.1016/j.mcpro.2021.100081_bib39 article-title: Differential quantitative determination of site-specific intact N-glycopeptides in serum haptoglobin between hepatocellular carcinoma and cirrhosis using LC-EThcD-MS/MS publication-title: J. Proteome Res. – volume: 11 start-page: 571 year: 2012 ident: 10.1016/j.mcpro.2021.100081_bib74 article-title: N-glycosylation of colorectal cancer tissues a liquid chromatography and mass spectrometry-based investigation publication-title: Mol. Cell. Proteomics doi: 10.1074/mcp.M111.011601 – volume: 14 start-page: 493 year: 2009 ident: 10.1016/j.mcpro.2021.100081_bib122 article-title: Proteomics-derived cerebrospinal fluid markers of autopsy-confirmed Alzheimer's disease publication-title: Biomarkers doi: 10.3109/13547500903108423 – volume: 29 start-page: 565 year: 2015 ident: 10.1016/j.mcpro.2021.100081_bib119 article-title: Genetic ablation of N-linked glycosylation reveals two key folding pathways for R345W fibulin-3, a secreted protein associated with retinal degeneration publication-title: FASEB J. doi: 10.1096/fj.14-255414 – volume: 50 start-page: 9377 year: 2011 ident: 10.1016/j.mcpro.2021.100081_bib109 article-title: The structural role of N-linked glycans on human glypican-1 publication-title: Biochemistry doi: 10.1021/bi200218s – volume: 42 start-page: 1 year: 2018 ident: 10.1016/j.mcpro.2021.100081_bib12 article-title: Recent advances in ion mobility–mass spectrometry for improved structural characterization of glycans and glycoconjugates publication-title: Curr. Opin. Chem. Biol. doi: 10.1016/j.cbpa.2017.10.007 – volume: 18 start-page: 1013 year: 2004 ident: 10.1016/j.mcpro.2021.100081_bib110 article-title: Glypican-1 as an Aβ binding HSPG in the human brain: Its localization in DIG domains and possible roles in the pathogenesis of Alzheimer's disease publication-title: FASEB J. doi: 10.1096/fj.03-1040fje – volume: 281 start-page: 46 year: 2014 ident: 10.1016/j.mcpro.2021.100081_bib16 article-title: The role of protein glycosylation in Alzheimer disease publication-title: FEBS J. doi: 10.1111/febs.12590 – volume: 1265 start-page: 158 year: 2009 ident: 10.1016/j.mcpro.2021.100081_bib127 article-title: Neuronal pentraxin receptor in cerebrospinal fluid as a potential biomarker for neurodegenerative diseases publication-title: Brain Res. doi: 10.1016/j.brainres.2009.01.058 – volume: 102 start-page: 285 year: 2002 ident: 10.1016/j.mcpro.2021.100081_bib59 article-title: Protein N-glycosylation along the secretory pathway: Relationship to organelle topography and function, protein quality control, and cell interactions publication-title: Chem. Rev. doi: 10.1021/cr000423j – volume: 169 start-page: 1347 year: 2010 ident: 10.1016/j.mcpro.2021.100081_bib108 article-title: Neurons associated with aggrecan-based perineuronal nets are protected against tau pathology in subcortical regions in Alzheimer's disease publication-title: Neuroscience doi: 10.1016/j.neuroscience.2010.05.022 – volume: 137 start-page: 10922 year: 2015 ident: 10.1016/j.mcpro.2021.100081_bib50 article-title: Extended O-GlcNAc on HLA class-I-bound peptides publication-title: J. Am. Chem. Soc. doi: 10.1021/jacs.5b06586 – volume: 9 start-page: 112 year: 1995 ident: 10.1016/j.mcpro.2021.100081_bib82 article-title: Acute phase reactant [alpha] 1Antichymotrypsin is increased in cerebrospinal fluid and serum of patients with probable Alzheimer disease publication-title: Alzheimer Dis. Assoc. Disord. doi: 10.1097/00002093-199509020-00009 – volume: 288 start-page: 18448 year: 2013 ident: 10.1016/j.mcpro.2021.100081_bib96 article-title: Biological and structural characterization of glycosylation on ephrin-A1, a preferred ligand for EphA2 receptor tyrosine kinase publication-title: J. Biol. Chem. doi: 10.1074/jbc.M113.464008 – volume: 103 start-page: 5573 year: 2006 ident: 10.1016/j.mcpro.2021.100081_bib149 article-title: Reelin expression and glycosylation patterns are altered in Alzheimer's disease publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.0601279103 – volume: 91 start-page: 2112 year: 2019 ident: 10.1016/j.mcpro.2021.100081_bib101 article-title: Hotmaq: A multiplexed absolute quantification method for targeted proteomics publication-title: Anal. Chem. doi: 10.1021/acs.analchem.8b04580 – volume: 54 start-page: 453 year: 2015 ident: 10.1016/j.mcpro.2021.100081_bib137 article-title: Association between serum haptoglobin and the pathogenesis of Alzheimer's disease publication-title: Intern. Med. doi: 10.2169/internalmedicine.54.2876 – volume: 279 start-page: 18146 year: 2004 ident: 10.1016/j.mcpro.2021.100081_bib143 article-title: The proteolytic processing of the amyloid precursor protein gene family members APLP-1 and APLP-2 involves α-, β-, γ-, and ε-like cleavages modulation of APLP-1 processing by N-glycosylation publication-title: J. Biol. Chem. doi: 10.1074/jbc.M311601200 – volume: 38 start-page: 567 year: 2014 ident: 10.1016/j.mcpro.2021.100081_bib142 article-title: Blood plasma IgG Fc glycans are significantly altered in Alzheimer's disease and progressive mild cognitive impairment publication-title: J. Alzheimers Dis. doi: 10.3233/JAD-131088 – volume: 278 start-page: 37386 year: 2003 ident: 10.1016/j.mcpro.2021.100081_bib152 article-title: Differential glycosylation regulates processing of lipoprotein receptors by γ-secretase publication-title: J. Biol. Chem. doi: 10.1074/jbc.M305858200 – volume: 36 start-page: 1057 year: 2015 ident: 10.1016/j.mcpro.2021.100081_bib105 article-title: Cerebellin 4, a synaptic protein, enhances inhibitory activity and resistance of neurons to amyloid-β toxicity publication-title: Neurobiol. Aging doi: 10.1016/j.neurobiolaging.2014.11.006 – volume: 18 start-page: 53 year: 2002 ident: 10.1016/j.mcpro.2021.100081_bib115 article-title: Synaptic proteins in Alzheimer's disease publication-title: J. Mol. Neurosci. doi: 10.1385/JMN:18:1-2:53 – volume: 1856 start-page: 211 year: 2015 ident: 10.1016/j.mcpro.2021.100081_bib65 article-title: Pathobiological implications of mucin glycans in cancer: Sweet poison and novel targets publication-title: Biochim. Biophys. Acta Rev. Cancer doi: 10.1016/j.bbcan.2015.08.003 – volume: 1 start-page: 805 year: 2007 ident: 10.1016/j.mcpro.2021.100081_bib5 article-title: Proteomics of human cerebrospinal fluid–the good, the bad, and the ugly publication-title: Proteomics Clin. Appl. doi: 10.1002/prca.200700081 – volume: 35 start-page: 2341 year: 2012 ident: 10.1016/j.mcpro.2021.100081_bib37 article-title: Glycopeptide enrichment and separation for protein glycosylation analysis publication-title: J. Sep. Sci. doi: 10.1002/jssc.201200434 – volume: 101 start-page: 10804 year: 2004 ident: 10.1016/j.mcpro.2021.100081_bib18 article-title: O-GlcNAcylation regulates phosphorylation of tau: A mechanism involved in Alzheimer's disease publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.0400348101 – volume: 55 start-page: 465 year: 2015 ident: 10.1016/j.mcpro.2021.100081_bib95 article-title: Eph receptors and ephrins: Therapeutic opportunities publication-title: Annu. Rev. Pharmacol. Toxicol. doi: 10.1146/annurev-pharmtox-011112-140226 – volume: 15 start-page: 540 year: 2015 ident: 10.1016/j.mcpro.2021.100081_bib10 article-title: Glycosylation in cancer: Mechanisms and clinical implications publication-title: Nat. Rev. Cancer doi: 10.1038/nrc3982 – volume: 19 start-page: 3452 year: 2020 ident: 10.1016/j.mcpro.2021.100081_bib41 article-title: Glycopeptide biomarkers in serum haptoglobin for hepatocellular carcinoma detection in patients with non-alcoholic steatohepatitis publication-title: J. Proteome Res. doi: 10.1021/acs.jproteome.0c00270 – volume: 92 start-page: 11119 year: 2020 ident: 10.1016/j.mcpro.2021.100081_bib102 article-title: Mass defect-based DiLeu tagging for multiplexed data-independent acquisition publication-title: Anal. Chem. doi: 10.1021/acs.analchem.0c01136 – volume: 58 start-page: 1267 year: 2017 ident: 10.1016/j.mcpro.2021.100081_bib151 article-title: Role of LRP1 in the pathogenesis of Alzheimer's disease: Evidence from clinical and preclinical studies publication-title: J. Lipid Res. doi: 10.1194/jlr.R075796 – volume: 23 start-page: 2078 year: 2006 ident: 10.1016/j.mcpro.2021.100081_bib17 article-title: Concurrent alterations of O-GlcNAcylation and phosphorylation of tau in mouse brains during fasting publication-title: Eur. J. Neurosci. doi: 10.1111/j.1460-9568.2006.04735.x – volume: 72 start-page: 1946 year: 2004 ident: 10.1016/j.mcpro.2021.100081_bib138 article-title: N-linked glycosylation is required for C1 inhibitor-mediated protection from endotoxin shock in mice publication-title: Infect. Immun. doi: 10.1128/IAI.72.4.1946-1955.2004 – volume: 13 start-page: 6176 year: 2014 ident: 10.1016/j.mcpro.2021.100081_bib44 article-title: Off-line high-pH reversed-phase fractionation for in-depth phosphoproteomics publication-title: J. Proteome Res. doi: 10.1021/pr500893m – volume: 17 start-page: 240 year: 2016 ident: 10.1016/j.mcpro.2021.100081_bib91 article-title: Mechanisms of ephrin-Eph signalling in development, physiology and disease publication-title: Nat. Rev. Mol. Cel. Biol. doi: 10.1038/nrm.2015.16 – volume: 4 start-page: 1537 year: 2004 ident: 10.1016/j.mcpro.2021.100081_bib61 article-title: Annotation of post-translational modifications in the Swiss-Prot knowledge base publication-title: Proteomics doi: 10.1002/pmic.200300764 – volume: 16 start-page: 440 year: 2006 ident: 10.1016/j.mcpro.2021.100081_bib132 article-title: Site-specific glycosylation analysis of the bovine lysosomal α-mannosidase publication-title: Glycobiology doi: 10.1093/glycob/cwj081 – volume: 26 start-page: 117 year: 2008 ident: 10.1016/j.mcpro.2021.100081_bib125 article-title: Sugar chains of cerebrospinal fluid transferrin as a new biological marker of Alzheimer's disease publication-title: Dement. Geriatr. Cogn. Disord. doi: 10.1159/000147479 – volume: 22 start-page: 1465 year: 2012 ident: 10.1016/j.mcpro.2021.100081_bib75 article-title: Comparative structural analysis of the glycosylation of salivary and buccal cell proteins: Innate protection against infection by Candida albicans publication-title: Glycobiology doi: 10.1093/glycob/cws112 – volume: 278 start-page: 6521 year: 2003 ident: 10.1016/j.mcpro.2021.100081_bib97 article-title: Sequence identification and characterization of human carnosinase and a closely related non-specific dipeptidase publication-title: J. Biol. Chem. doi: 10.1074/jbc.M209764200 – volume: 6 start-page: 35 year: 2014 ident: 10.1016/j.mcpro.2021.100081_bib148 article-title: Dietary regulation of PI3K/AKT/GSK-3β pathway in Alzheimer's disease publication-title: Alzheimers Res. Ther. doi: 10.1186/alzrt265 – volume: 453 start-page: 243 year: 2014 ident: 10.1016/j.mcpro.2021.100081_bib113 article-title: Physiologic and pathophysiologic consequences of altered sialylation and glycosylation on ion channel function publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/j.bbrc.2014.06.067 – volume: 272 start-page: 7229 year: 1997 ident: 10.1016/j.mcpro.2021.100081_bib124 article-title: The glycosylation of the complement regulatory protein, human erythrocyte CD59 publication-title: J. Biol. Chem. doi: 10.1074/jbc.272.11.7229 – year: 2009 ident: 10.1016/j.mcpro.2021.100081_bib77 – volume: 134 start-page: 1152 year: 2015 ident: 10.1016/j.mcpro.2021.100081_bib145 article-title: Dickkopf-related protein 3 is a potential Aβ-associated protein in Alzheimer's Disease publication-title: J. Neurochem. doi: 10.1111/jnc.13216 – volume: 118 start-page: 880 year: 2019 ident: 10.1016/j.mcpro.2021.100081_bib13 article-title: Recent advances in mass spectrometry (MS)-based glycoproteomics in complex biological samples publication-title: Trac Trends Anal. Chem. doi: 10.1016/j.trac.2018.10.009 – volume: 7 start-page: 378 year: 2013 ident: 10.1016/j.mcpro.2021.100081_bib111 article-title: Sortilin, a novel APOE receptor implicated in Alzheimer disease publication-title: Prion doi: 10.4161/pri.26746 – volume: 59 start-page: 369 year: 1983 ident: 10.1016/j.mcpro.2021.100081_bib2 article-title: Recent research into the nature of cerebrospinal fluid formation and absorption publication-title: J. Neurosurg. doi: 10.3171/jns.1983.59.3.0369 – volume: 15 start-page: 3904 year: 2016 ident: 10.1016/j.mcpro.2021.100081_bib34 article-title: Toward automated N-glycopeptide identification in glycoproteomics publication-title: J. Proteome Res. doi: 10.1021/acs.jproteome.6b00438 – volume: 71 start-page: 186 year: 2008 ident: 10.1016/j.mcpro.2021.100081_bib68 article-title: Mass spectrometric and linear discriminant analysis of N-glycans of human serum alpha-1-acid glycoprotein in cancer patients and healthy individuals publication-title: J. Proteomics doi: 10.1016/j.jprot.2008.04.005 – volume: 9 start-page: 293 year: 2006 ident: 10.1016/j.mcpro.2021.100081_bib4 article-title: Detection of biomarkers with a multiplex quantitative proteomic platform in cerebrospinal fluid of patients with neurodegenerative disorders publication-title: J. Alzheimers Dis. doi: 10.3233/JAD-2006-9309 – volume: 76 start-page: 1411 year: 2001 ident: 10.1016/j.mcpro.2021.100081_bib120 article-title: Fibulin-1 binds the amino-terminal head of β-amyloid precursor protein and modulates its physiological function publication-title: J. Neurochem. doi: 10.1046/j.1471-4159.2001.00144.x – volume: 131 start-page: 29 year: 2016 ident: 10.1016/j.mcpro.2021.100081_bib20 article-title: CSF N-glycoproteomics for early diagnosis in Alzheimer's disease publication-title: J. Proteomics doi: 10.1016/j.jprot.2015.10.006 – volume: 113 start-page: 784 year: 2010 ident: 10.1016/j.mcpro.2021.100081_bib117 article-title: Abnormal post-translational and extracellular processing of brevican in plaque-bearing mice over-expressing APPsw publication-title: J. Neurochem. doi: 10.1111/j.1471-4159.2010.06647.x – volume: 102 start-page: 4252 year: 2005 ident: 10.1016/j.mcpro.2021.100081_bib80 article-title: On the utility of pooling biological samples in microarray experiments publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.0500607102 – volume: 24 start-page: 606 year: 2012 ident: 10.1016/j.mcpro.2021.100081_bib94 article-title: Eph receptors at synapses: Implications in neurodegenerative diseases publication-title: Cell. Signal. doi: 10.1016/j.cellsig.2011.11.016 – volume: 16 start-page: 389 year: 2009 ident: 10.1016/j.mcpro.2021.100081_bib140 article-title: Reduced levels of amyloid-β-binding proteins in cerebrospinal fluid from Alzheimer's disease patients publication-title: J. Alzheimers Dis. doi: 10.3233/JAD-2009-0966 – volume: 20 start-page: 7505 year: 2000 ident: 10.1016/j.mcpro.2021.100081_bib123 article-title: Deficiency of complement defense protein CD59 may contribute to neurodegeneration in Alzheimer's disease publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.20-20-07505.2000 – volume: 15 start-page: 2960 year: 2016 ident: 10.1016/j.mcpro.2021.100081_bib24 article-title: Evaluation of different N-glycopeptide enrichment methods for N-glycosylation sites mapping in mouse brain publication-title: J. Proteome Res. doi: 10.1021/acs.jproteome.6b00098 – volume: 28 start-page: 1751 year: 2017 ident: 10.1016/j.mcpro.2021.100081_bib51 article-title: Electron-transfer/higher-energy collision dissociation (EThcD)-Enabled intact glycopeptide/glycoproteome characterization publication-title: J. Am. Soc. Mass Spectrom. doi: 10.1007/s13361-017-1701-4 – volume: 292 start-page: 11079 year: 2017 ident: 10.1016/j.mcpro.2021.100081_bib64 article-title: N-glycosylation affects the stability and barrier function of the MUC16 mucin publication-title: J. Biol. Chem doi: 10.1074/jbc.M116.770123 – volume: 19 start-page: 2606 year: 2020 ident: 10.1016/j.mcpro.2021.100081_bib7 article-title: Isobaric labeling strategy utilizing 4-plex N, N-dimethyl leucine (DiLeu) tags reveals proteomic changes induced by chemotherapy in cerebrospinal fluid of children with B-cell acute lymphoblastic leukemia publication-title: J. Proteome Res. doi: 10.1021/acs.jproteome.0c00291 – volume: 197 start-page: 209 year: 1991 ident: 10.1016/j.mcpro.2021.100081_bib90 article-title: Structure determination of the glycans of human-serum α1-antichymotrypsin using 1H-NMR spectroscopy and deglycosylation by N-glycanase publication-title: FEBS J. – volume: 275 start-page: 39096 year: 2000 ident: 10.1016/j.mcpro.2021.100081_bib107 article-title: Age-related changes in aggrecan glycosylation affect cleavage by aggrecanase publication-title: J. Biol. Chem. doi: 10.1074/jbc.M006201200 – volume: 1585 start-page: 1 year: 2014 ident: 10.1016/j.mcpro.2021.100081_bib129 article-title: The protective role of prosaposin and its receptors in the nervous system publication-title: Brain Res. doi: 10.1016/j.brainres.2014.08.022 – volume: 8 start-page: 1534 year: 2005 ident: 10.1016/j.mcpro.2021.100081_bib106 article-title: Cbln1 is essential for synaptic integrity and plasticity in the cerebellum publication-title: Nat. Neurosci. doi: 10.1038/nn1576 – volume: 33 start-page: 309 year: 2016 ident: 10.1016/j.mcpro.2021.100081_bib121 article-title: Human plasma protein N publication-title: Glycoconj. J. doi: 10.1007/s10719-015-9626-2 – volume: 8 start-page: 515 year: 2012 ident: 10.1016/j.mcpro.2021.100081_bib135 article-title: Ceruloplasmin and iron in Alzheimer's disease and Parkinson's disease: A synopsis of recent studies publication-title: Neuropsychiatr. Dis. Treat. – volume: 11 start-page: 483 year: 2019 ident: 10.1016/j.mcpro.2021.100081_bib53 article-title: A strategy for discovery and verification of candidate biomarkers in cerebrospinal fluid of preclinical Alzheimer’s disease publication-title: Front. Mol. Neurosci. doi: 10.3389/fnmol.2018.00483 – volume: 344 start-page: 1391 year: 2009 ident: 10.1016/j.mcpro.2021.100081_bib70 article-title: Paucimannose N-glycans in Caenorhabditis elegans and Drosophila melanogaster publication-title: Carbohydr. Res. doi: 10.1016/j.carres.2009.04.028 – volume: 28 start-page: 961 year: 1996 ident: 10.1016/j.mcpro.2021.100081_bib81 article-title: α1-antichymotrypsin publication-title: Int. J. Biochem. Cell Biol. doi: 10.1016/1357-2725(96)00032-5 – volume: 20 start-page: S1 year: 2010 ident: 10.1016/j.mcpro.2021.100081_bib153 article-title: Role of selenoprotein P in Alzheimer's disease publication-title: Ethn. Dis. – volume: 8 start-page: 1 year: 2017 ident: 10.1016/j.mcpro.2021.100081_bib55 article-title: pGlyco 2.0 enables precision N-glycoproteomics with comprehensive quality control and one-step mass spectrometry for intact glycopeptide identification publication-title: Nat. Commun. – volume: 143 start-page: 2508 year: 2018 ident: 10.1016/j.mcpro.2021.100081_bib38 article-title: Site-specific characterization and quantitation of N-glycopeptides in PKM2 knockout breast cancer cells using DiLeu isobaric tags enabled by electron-transfer/higher-energy collision dissociation (EThcD) publication-title: Analyst doi: 10.1039/C8AN00216A – volume: 290 start-page: 8789 year: 2015 ident: 10.1016/j.mcpro.2021.100081_bib76 article-title: Human neutrophils secrete bioactive paucimannosidic proteins from azurophilic granules into pathogen-infected sputum publication-title: J. Biol. Chem. doi: 10.1074/jbc.M114.631622 – volume: 409 start-page: 4437 year: 2017 ident: 10.1016/j.mcpro.2021.100081_bib11 article-title: Development of a hydrophilic interaction liquid chromatography coupled with matrix-assisted laser desorption/ionization-mass spectrometric imaging platform for N-glycan relative quantitation using stable-isotope labeled hydrazide reagents publication-title: Anal. Bioanal. Chem. doi: 10.1007/s00216-017-0387-6 – volume: 17 start-page: 781 year: 2013 ident: 10.1016/j.mcpro.2021.100081_bib150 article-title: Targeting ApoE4/ApoE receptor LRP1 in Alzheimer's disease publication-title: Expert Opin. Ther. Targets doi: 10.1517/14728222.2013.789862 – volume: 7 start-page: S6 year: 2010 ident: 10.1016/j.mcpro.2021.100081_bib92 article-title: Altered glycosylation profile of purified plasma ACT from Alzheimer’s disease publication-title: Immun. Ageing doi: 10.1186/1742-4933-7-S1-S6 – volume: 372 start-page: 92 year: 1994 ident: 10.1016/j.mcpro.2021.100081_bib83 article-title: Amyloid-associated proteins α1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer β-protein into filaments publication-title: Nature doi: 10.1038/372092a0 – volume: 6 start-page: 359 year: 2009 ident: 10.1016/j.mcpro.2021.100081_bib27 article-title: Universal sample preparation method for proteome analysis publication-title: Nat. Methods doi: 10.1038/nmeth.1322 – volume: 51 start-page: 169 year: 2002 ident: 10.1016/j.mcpro.2021.100081_bib62 article-title: Distribution and partial characterisation of IgG Fc binding protein in various mucin producing cells and body fluids publication-title: Gut doi: 10.1136/gut.51.2.169 – volume: 2016 start-page: 6427537 year: 2016 ident: 10.1016/j.mcpro.2021.100081_bib103 article-title: Synaptic cell adhesion molecules in Alzheimer's disease publication-title: Neural Plast. – volume: 111 start-page: 313 year: 2009 ident: 10.1016/j.mcpro.2021.100081_bib3 article-title: A modern approach to CSF analysis: Pathophysiology, clinical application, proof of concept and laboratory reporting publication-title: Clin. Neurol. Neurosurg. doi: 10.1016/j.clineuro.2008.12.004 – volume: 17 start-page: 773 year: 1996 ident: 10.1016/j.mcpro.2021.100081_bib84 article-title: Alzheimer Aβ neurotoxicity: Promotion by antichymotrypsin, apoE4; inhibition by Aβ-related peptides publication-title: Neurobiol. Aging doi: 10.1016/0197-4580(96)00112-1 – volume: 151 start-page: 327 year: 1985 ident: 10.1016/j.mcpro.2021.100081_bib88 article-title: Human serum α1-antichymotrypsin is an inhibitor of pancreatic elastases publication-title: FEBS J. – volume: 105 start-page: 975 year: 2020 ident: 10.1016/j.mcpro.2021.100081_bib58 article-title: Deep multilayer brain proteomics identifies molecular networks in Alzheimer’s disease progression publication-title: Neuron doi: 10.1016/j.neuron.2019.12.015 – volume: 115 start-page: 842 year: 2013 ident: 10.1016/j.mcpro.2021.100081_bib25 article-title: Brush polymer modified and lectin immobilized core–shell microparticle for highly efficient glycoprotein/glycopeptide enrichment publication-title: Talanta doi: 10.1016/j.talanta.2013.06.031 – volume: 281 start-page: 12776 year: 2006 ident: 10.1016/j.mcpro.2021.100081_bib69 article-title: Null mutations in Drosophila N-acetylglucosaminyltransferase I produce defects in locomotion and a reduced life span publication-title: J. Biol. Chem. doi: 10.1074/jbc.M512769200 – volume: 9 start-page: 22 year: 2014 ident: 10.1016/j.mcpro.2021.100081_bib126 article-title: Identification of longitudinally dynamic biomarkers in Alzheimer's disease cerebrospinal fluid by targeted proteomics publication-title: Mol. Neurodegener. doi: 10.1186/1750-1326-9-22 – volume: 48 start-page: 10286 year: 2009 ident: 10.1016/j.mcpro.2021.100081_bib128 article-title: GPR37 surface expression enhancement via N-terminal truncation or protein−protein interactions publication-title: Biochemistry doi: 10.1021/bi9013775 – volume: 91 start-page: 11589 year: 2019 ident: 10.1016/j.mcpro.2021.100081_bib40 article-title: Dual-functional titanium (IV) immobilized metal affinity chromatography approach for enabling large-scale profiling of protein mannose-6-phosphate glycosylation and revealing its predominant substrates publication-title: Anal. Chem. doi: 10.1021/acs.analchem.9b01698 – volume: 34 start-page: 911 year: 1988 ident: 10.1016/j.mcpro.2021.100081_bib89 article-title: Alpha 1-antichymotrypsin microheterogeneity in crossed immunoaffinoelectrophoresis with free concanavalin A: A useful diagnostic tool in inflammatory syndrome publication-title: Clin. Chem. doi: 10.1093/clinchem/34.5.911 – volume: 4 start-page: R60 year: 2003 ident: 10.1016/j.mcpro.2021.100081_bib57 article-title: David: Database for annotation, visualization, and integrated discovery publication-title: Genome Biol. doi: 10.1186/gb-2003-4-9-r60 – volume: 87 start-page: 1646 year: 2014 ident: 10.1016/j.mcpro.2021.100081_bib100 article-title: High-resolution enabled 12-plex DiLeu isobaric tags for quantitative proteomics publication-title: Anal. Chem. doi: 10.1021/ac503276z – volume: 16 start-page: 617 year: 1993 ident: 10.1016/j.mcpro.2021.100081_bib1 article-title: Extracellular and cerebrospinal fluids publication-title: J. Inherit. Metab. Dis. doi: 10.1007/BF00711896 – volume: 8 start-page: 393 year: 2012 ident: 10.1016/j.mcpro.2021.100081_bib19 article-title: Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation publication-title: Nat. Chem. Biol. doi: 10.1038/nchembio.797 – volume: 84 start-page: 9668 year: 2012 ident: 10.1016/j.mcpro.2021.100081_bib49 article-title: Toward full peptide sequence coverage by dual fragmentation combining electron-transfer and higher-energy collision dissociation tandem mass spectrometry publication-title: Anal. Chem. doi: 10.1021/ac3025366 – volume: 4 start-page: 2070 year: 2005 ident: 10.1016/j.mcpro.2021.100081_bib52 article-title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry publication-title: J. Proteome Res. doi: 10.1021/pr0502065 – volume: 278 start-page: 33239 year: 2003 ident: 10.1016/j.mcpro.2021.100081_bib116 article-title: A novel membrane-associated glycovariant of BEHAB/brevican is up-regulated during rat brain development and in a rat model of invasive glioma publication-title: J. Biol. Chem. doi: 10.1074/jbc.M303480200 – volume: 125 start-page: 2478 year: 2012 ident: 10.1016/j.mcpro.2021.100081_bib104 article-title: N-glycosylation alters cadherin-mediated intercellular binding kinetics publication-title: J. Cell Sci. – volume: 59 start-page: 1984 year: 2010 ident: 10.1016/j.mcpro.2021.100081_bib99 article-title: N-glycosylation of carnosinase influences protein secretion and enzyme activity: implications for hyperglycemia publication-title: Diabetes doi: 10.2337/db09-0868 – volume: 13 start-page: 277 year: 2013 ident: 10.1016/j.mcpro.2021.100081_bib73 article-title: Comparative N-glycan profiling of colorectal cancer cell lines reveals unique bisecting GlcNAc and α-2, 3-linked sialic acid determinants are associated with membrane proteins of the more metastatic/aggressive cell lines publication-title: J. Proteome Res. doi: 10.1021/pr400861m – volume: 3 start-page: 22683 year: 2013 ident: 10.1016/j.mcpro.2021.100081_bib46 article-title: Structural analysis of glycoprotein sialylation–part I: Pre-LC-MS analytical strategies publication-title: Rsc Adv. doi: 10.1039/c3ra42960a – volume: 141 start-page: 897 year: 2010 ident: 10.1016/j.mcpro.2021.100081_bib26 article-title: Precision mapping of an in vivo N-glycoproteome reveals rigid topological and sequence constraints publication-title: Cell doi: 10.1016/j.cell.2010.04.012 – volume: 157 start-page: 2003 year: 2000 ident: 10.1016/j.mcpro.2021.100081_bib86 article-title: Astroglial expression of human α 1-antichymotrypsin enhances Alzheimer-like pathology in amyloid protein precursor transgenic mice publication-title: Am. J. Pathol. doi: 10.1016/S0002-9440(10)64839-0 – volume: 10 start-page: 175 year: 2016 ident: 10.1016/j.mcpro.2021.100081_bib112 article-title: Modulation of Cav3. 2 T-type calcium channel permeability by asparagine-linked glycosylation publication-title: Channels doi: 10.1080/19336950.2016.1138189 – volume: 22 start-page: 39 year: 2006 ident: 10.1016/j.mcpro.2021.100081_bib6 article-title: Identification of disease markers in human cerebrospinal fluid using lipidomic and proteomic methods publication-title: Dis. Markers doi: 10.1155/2006/202938 – volume: 40 year: 2012 ident: 10.1016/j.mcpro.2021.100081_bib32 article-title: Byonic: Advanced peptide and protein identification software publication-title: Curr. Protoc. Bioinformatics doi: 10.1002/0471250953.bi1320s40 – volume: 10 start-page: 1225 year: 2016 ident: 10.1016/j.mcpro.2021.100081_bib23 article-title: Label-free quantitative comparison of cerebrospinal fluid glycoproteins and endogenous peptides in subjects with Alzheimer's disease, mild cognitive impairment, and healthy individuals publication-title: Proteomics Clin. Appl. doi: 10.1002/prca.201600009 – volume: 22 start-page: 416 year: 2008 ident: 10.1016/j.mcpro.2021.100081_bib93 article-title: Eph/ephrin signaling: Networks publication-title: Genes Dev. doi: 10.1101/gad.1630408 – volume: 29 start-page: 461 year: 2015 ident: 10.1016/j.mcpro.2021.100081_bib22 article-title: Evaluation of a combined glycomics and glycoproteomics approach for studying the major glycoproteins present in biofluids: Application to cerebrospinal fluid publication-title: Rapid Commun. Mass Spectrom. doi: 10.1002/rcm.7125 – volume: 19 start-page: 634 year: 2019 ident: 10.1016/j.mcpro.2021.100081_bib43 article-title: Signature-ion-triggered mass spectrometry approach enabled discovery of N-and O-linked glycosylated neuropeptides in the Crustacean nervous system publication-title: J. Proteome Res. doi: 10.1021/acs.jproteome.9b00525 – volume: 30 start-page: 2967 year: 2009 ident: 10.1016/j.mcpro.2021.100081_bib79 article-title: The consequences of sample pooling in proteomics: An empirical study publication-title: Electrophoresis doi: 10.1002/elps.200900210 – volume: 34 start-page: 484 year: 2009 ident: 10.1016/j.mcpro.2021.100081_bib133 article-title: Cerebrospinal fluid beta-glucocerebrosidase activity is reduced in dementia with Lewy bodies publication-title: Neurobiol. Dis. doi: 10.1016/j.nbd.2009.03.002 – volume: 13 start-page: 3152 year: 2014 ident: 10.1016/j.mcpro.2021.100081_bib8 article-title: In-depth characterization of the cerebrospinal fluid (CSF) proteome displayed through the CSF proteome resource (CSF-PR) publication-title: Mol. Cell. Proteomics doi: 10.1074/mcp.M114.038554 – volume: 1473 start-page: 4 year: 1999 ident: 10.1016/j.mcpro.2021.100081_bib35 article-title: On the frequency of protein glycosylation, as deduced from analysis of the SWISS-PROT database publication-title: Biochim. Biophys. Acta doi: 10.1016/S0304-4165(99)00165-8 – volume: 17 start-page: 1125 year: 2020 ident: 10.1016/j.mcpro.2021.100081_bib56 article-title: Fast and comprehensive N-and O-glycoproteomics analysis with MSFragger-Glyco publication-title: Nat. Methods doi: 10.1038/s41592-020-0967-9 |
| SSID | ssj0020175 |
| Score | 2.5517995 |
| Snippet | As the body fluid that directly interchanges with the extracellular fluid of the central nervous system (CNS), cerebrospinal fluid (CSF) serves as a rich... |
| SourceID | pubmedcentral proquest pubmed crossref elsevier |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 100081 |
| SubjectTerms | Alzheimer Disease - cerebrospinal fluid Cell Line cerebrospinal fluid electron-transfer higher-energy collision induced dissociation (EThcD) glycopeptide enrichment Glycopeptides - cerebrospinal fluid Glycoproteins - cerebrospinal fluid Glycosylation Humans N-glycoproteome analysis Proteome - analysis site-specific intact glycopeptide characterization |
| Title | In-depth Site-specific Analysis of N-glycoproteome in Human Cerebrospinal Fluid and Glycosylation Landscape Changes in Alzheimer's Disease |
| URI | https://dx.doi.org/10.1016/j.mcpro.2021.100081 https://www.ncbi.nlm.nih.gov/pubmed/33862227 https://www.proquest.com/docview/2514604591 https://pubmed.ncbi.nlm.nih.gov/PMC8724636 |
| Volume | 20 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3bbtNAEF2FIlBfKmihhJsWCcFDcBQ7vj6WiFIQrUC0UsWLZa_XjavEjhpHVfoJ_B4_xMzeaidQQV-cZLNerzzH65nZMzOEvI5cO4wSNwAjJwEDxXdtK8yz3OI598Khn2YOQz_k4ZF_cOJ-PvVOO51fDdbSok777OqPcSW3kSq0gVwxSvY_JGsGhQb4DvKFI0gYjv8k40-llfFZPe59B8XRwqBJJP60Eo0cWWeTJatEOoZqKjKESL_9iF-AOYxVQ1Af3Z8sCpG0tfcRu8-XkiLX-4KRwMiRUmEIgj27N7ka80KUXQnmmL_TbPHo0lC65q4AFu4NiB9qEg1-_UjFhvyAz7NLXpg1aIGt34pyqd-szUbTosp7CSQKv1HZdGI49ooTw-xONamq7wusGSaL3knWiZm8rNO5bK3bnhW5gcqq3WyTFej0Yi8i79bfG9KFcd6fMrgVfZwh0kcGsppMA0mzqYAS2PU-BhFfv0QNtfHr4SgMHEzDdofcdcB2cbSdr7wAsAR6MomvnLFOhSVIh2vX3yT39cX-pjmtW0arBN-GxnT8gGwpU4fuSdw-JB1ebpMdAGddTZf0DRXkY3GHt8k9da93yE8NatoCNdWgplVOV0BNi5IKUNMWqKkANQWZ0haoqQE1VaDGAQyo386pgvQjcrL_4Xh0YKmCIRZzvai2kuHQY7bDw4zz3EsHGWjjgySwM9_JssSzs9QesIQxJ4iwj21zN0zdnCch4wGDtekx2Sirkj8hNGAZ9PJB_04zrGUd2YmdJq7npQ6MPUy6xNHCiJnKpo9FXSaxpk2ex0KYMQozlsLsknfmpJlMJnNzd19LOVb6sNRzY4DtzSe-0piI4fnBxzwpebWYx2DNuD5YcRH02ZUYMTPROOuSoIUe0wEz0bf_KYuxyEivEP_01mc-I5vXy8JzslFfLPgL0Pbr9KV4en4DsFAIqA |
| linkProvider | Directory of Open Access Journals |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=In-depth+Site-specific+Analysis+of+N-glycoproteome+in+Human+Cerebrospinal+Fluid+and+Glycosylation+Landscape+Changes+in+Alzheimer%27s+Disease&rft.jtitle=Molecular+%26+cellular+proteomics&rft.au=Chen%2C+Zhengwei&rft.au=Yu%2C+Qinying&rft.au=Yu%2C+Qing&rft.au=Johnson%2C+Jillian&rft.date=2021-01-01&rft.pub=American+Society+for+Biochemistry+and+Molecular+Biology&rft.issn=1535-9476&rft.eissn=1535-9484&rft.volume=20&rft_id=info:doi/10.1016%2Fj.mcpro.2021.100081&rft_id=info%3Apmid%2F33862227&rft.externalDocID=PMC8724636 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1535-9476&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1535-9476&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1535-9476&client=summon |