Oxidative stress markers in the neocortex of drug-resistant epilepsy patients submitted to epilepsy surgery

• Published in: Epilepsy research Vol. 107; no. 1; pp. 75 - 81
• Main Authors: Rumià, Jordi, Marmol, Frederic, Sanchez, Juan, Giménez-Crouseilles, José, Carreño, Mar, Bargalló, Núria, Boget, Teresa, Pintor, Luis, Setoain, Xavier, Donaire, Antonio, Saez, Guillermo T, Ribalta, Teresa, Ferrer, Enric, Puig-Parellada, Pere
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier B.V 01.11.2013; Elsevier
• Subjects: Adult; Anticonvulsants - therapeutic use; Biological and medical sciences; Biomarkers - metabolism; Catalase - metabolism; Drug-resistant epilepsy; Epilepsy - drug therapy; Epilepsy - metabolism; Epilepsy - surgery; Female; Glutathione Peroxidase - metabolism; Glutathione Reductase - metabolism; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy; Humans; Male; Medical sciences; Middle Aged; Neocortex; Neocortex - metabolism; Neocortex - surgery; Nervous system (semeiology, syndromes); Neurology; Oxidative stress; Oxidative Stress - physiology; Psychosurgery; Retreatment; Seizures; Superoxide Dismutase - metabolism; Treatment Failure; Oxidative stress; Drug-resistant epilepsy; Neocortex; Epilepsy surgery; Seizures; Human; Drug; Nervous system diseases; Epilepsy; Cerebral disorder; Convulsion; Surgery; Central nervous system disease; Neurological disorder

Summary Purpose While there is solid experimental evidence of brain oxidative stress in animal models of epilepsy, it has not been thoroughly verified in epileptic human brain. Our purpose was to determine and to compare oxidative stress markers in the neocortex of epileptic and non-epileptic humans...