Brief postnatal exposure to bisphenol A affects apoptosis and gene expression in the medial prefrontal cortex and social behavior in rats with sex specificity

• Published in: Neurotoxicology (Park Forest South) Vol. 94; pp. 126 - 134
• Main Authors: Drzewiecki, Carly M., Brinks, Amara S., Sellinger, Elli P., Doshi, Aditi D., Koh, Jessie Y., Juraska, Janice M.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.01.2023
• Subjects: Adolescent; Animals; Apoptosis; Autism; Autism Spectrum Disorder - metabolism; Benzhydryl Compounds - metabolism; Benzhydryl Compounds - toxicity; BPA; Endocrine disruptor; Endocrine Disruptors - toxicity; Female; Gene Expression; Male; Prefrontal Cortex; Pregnancy; Prenatal Exposure Delayed Effects - chemically induced; Prenatal Exposure Delayed Effects - metabolism; Rats; Shank3; Social Behavior; Social preference; Social preference; Autism; BPA; Endocrine disruptor; Shank3

Bisphenol A (BPA) is an endocrine disruptor found in polycarbonate plastics and exposure in humans is nearly ubiquitous and it has widespread effects on cognitive, emotional, and reproductive behaviors in both humans and animal models. In our laboratory we previously found that perinatal BPA exposur...