Daphnane diterpenoid orthoesters with an odd-numbered aliphatic side chain from Daphne pedunculata

• Published in: Journal of natural medicines Vol. 78; no. 4; pp. 901 - 907
• Main Authors: Tan, Lingjian, Otsuki, Kouharu, Kikuchi, Takashi, Zhou, Di, Li, Ning, Huang, Li, Chen, Chin-Ho, Li, Wei
• Format: Journal Article
• Language: English
• Published: Singapore Springer Nature Singapore 01.09.2024; Springer Nature B.V
• Subjects: Anti-HIV Agents - chemistry; Anti-HIV Agents - isolation & purification; Anti-HIV Agents - pharmacology; antiretroviral properties; Antiviral activity; Biomedical and Life Sciences; Biomedicine; Cell Line; Complementary & Alternative Medicine; Daphne; Daphne - chemistry; Diterpenes; Diterpenes - chemistry; Diterpenes - isolation & purification; Diterpenes - pharmacology; diterpenoids; Esters - chemistry; HIV; HIV infections; HIV-1 - drug effects; Human immunodeficiency virus; Humans; Medicinal Chemistry; Molecular Structure; Original Paper; ortho esters; Orthoesters; Pharmacology/Toxicology; Pharmacy; phytochemicals; Plant Extracts - chemistry; Plant Extracts - pharmacology; Plant Sciences; spectroscopy; Tandem Mass Spectrometry; Anti-HIV; Odd-numbered aliphatic side chain; Thymelaeaceae; Daphnane; Daphne pedunculata

Daphnane diterpenoids were recognized for their extensive range of potent biological activities. In the present study, phytochemical investigation including LC–MS/MS analysis resulted in the identification of five daphnane diterpenoid orthoesters ( 1 – 5 ). Among the five daphnane diterpenoids, two...