Expression of epithelial growth factor receptor as a protein marker in oral reticular and erosive lichen planus

• Published in: BMC oral health Vol. 24; no. 1; pp. 726 - 9
• Main Authors: Keshani, Forooz, Kargahi, Neda, Nikbakht, Mohammad Hossein, Najafi, Shekufe, Fallah, Fateme
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 24.06.2024; BioMed Central; BMC
• Subjects: Adult; Aged; Antibodies; Antigens; Biomarkers; Biomarkers - analysis; Cross-Sectional Studies; Development and progression; EGFR; Epidermal growth factor receptors; Epithelial growth factor receptor; Epithelium; ErbB Receptors - analysis; ErbB Receptors - metabolism; Female; Fibroblast growth factor 2; Growth factor receptors; Growth factors; Health aspects; Humans; Hyperplasia; Immunohistochemistry; Inflammatory diseases; Kinases; Lesions; Lichen planus; Lichen Planus, Oral - metabolism; Lichen Planus, Oral - pathology; Male; Maxillofacial; Middle Aged; Oral cancer; Oral lichen planus; Paraffin; Precancerous Conditions - metabolism; Precancerous Conditions - pathology; Skin diseases; Squamous cell carcinoma; Statistical methods; Tumorigenesis; Ulcers; Iran; Immunohistochemistry; Oral lichen planus; Epithelial growth factor receptor; EGFR

Oral lichen planus (OLP) is a chronic inflammatory mucosal disease that is classified as a premalignant condition. Epithelial growth factor receptor (EGFR) is associated with tumorigenesis and tumor progression and is overexpressed in several oral malignant disorders. Despite the association of EGFR...