Far-red light-activated human islet-like designer cells enable sustained fine-tuned secretion of insulin for glucose control

• Published in: Molecular therapy Vol. 30; no. 1; pp. 341 - 354
• Main Authors: Yu, Guiling, Zhang, Mingliang, Gao, Ling, Zhou, Yang, Qiao, Longliang, Yin, Jianli, Wang, Yiwen, Zhou, Jian, Ye, Haifeng
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 05.01.2022; American Society of Gene & Cell Therapy
• Subjects: Animals; Blood Glucose; blood glucose control; cell therapy; Diabetes Mellitus, Type 1 - therapy; Diabetes Mellitus, Type 2; far-red light; Humans; Insulin - metabolism; Insulin Secretion; Mice; optogenetics; Original; oxidative stress; renal damage; synthetic designer cell; type 1 diabetes; type 1 diabetes; far-red light; cell therapy; optogenetics; synthetic designer cell; blood glucose control; oxidative stress; renal damage

Diabetes affects almost half a billion people, and all individuals with type 1 diabetes (T1D) and a large portion of individuals with type 2 diabetes rely on self-administration of the peptide hormone insulin to achieve glucose control. However, this treatment modality has cumbersome storage and equ...