Isolated Renal Mucormycosis in Immunocompetent Hosts: Clinical Spectrum and Management Approach
Isolated renal mucormycosis in immunocompetent hosts is a rare entity. We present the largest case series of isolated renal mucormycosis in immunocompetent hosts. Retrospective data of isolated renal mucormycosis from March 2012 to June 2017 was reviewed. Fifteen patients of isolated renal mucormyco...
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Published in | The American journal of tropical medicine and hygiene Vol. 100; no. 4; pp. 791 - 797 |
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Main Authors | , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
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United States
Institute of Tropical Medicine
01.01.2019
The American Society of Tropical Medicine and Hygiene |
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Abstract | Isolated renal mucormycosis in immunocompetent hosts is a rare entity. We present the largest case series of isolated renal mucormycosis in immunocompetent hosts. Retrospective data of isolated renal mucormycosis from March 2012 to June 2017 was reviewed. Fifteen patients of isolated renal mucormycosis were identified. Contrast-enhanced computed tomography scan showed enlarged globular kidneys with decreased or patchy enhancement, perinephric stranding and thickened Gerota's fascia in all patients. Ten patients with unilateral involvement underwent nephrectomy and two of four patients with bilateral renal mucormycosis underwent bilateral nephrectomy. Two patients were managed with intravenous antifungal therapy alone. Overall, the mortality rate in our series was 40% (6/15). Isolated renal mucormycosis in healthy immunocompetent hosts is an emerging new entity. Prompt diagnosis based on the characteristic clinical and radiological picture and starting high-dose antifungal therapy at least 24 hours before surgical debridement offer the best chance of survival in these patients. |
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AbstractList | Isolated renal mucormycosis in immunocompetent hosts is a rare entity. We present the largest case series of isolated renal mucormycosis in immunocompetent hosts. Retrospective data of isolated renal mucormycosis from March 2012 to June 2017 was reviewed. Fifteen patients of isolated renal mucormycosis were identified. Contrast-enhanced computed tomography scan showed enlarged globular kidneys with decreased or patchy enhancement, perinephric stranding and thickened Gerota's fascia in all patients. Ten patients with unilateral involvement underwent nephrectomy and two of four patients with bilateral renal mucormycosis underwent bilateral nephrectomy. Two patients were managed with intravenous antifungal therapy alone. Overall, the mortality rate in our series was 40% (6/15). Isolated renal mucormycosis in healthy immunocompetent hosts is an emerging new entity. Prompt diagnosis based on the characteristic clinical and radiological picture and starting high-dose antifungal therapy at least 24 hours before surgical debridement offer the best chance of survival in these patients. |
Author | Bora, Girdhar S Parmar, Kalpesh M Gupta, Vijayanth G Mavuduru, Ravimohan S Ghosh, Anup Kakkar, Nandita Banerjee, Nirmalya Devana, Sudheer K Sharma, Aditya P Mete, Uttam K Singh, Shrawan K Kumar, Santosh Mandal, Arup K |
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Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Authors’ addresses: Sudheer K. Devana, Vijayanth G. Gupta, Ravimohan S. Mavuduru, Girdhar S. Bora, Aditya P. Sharma, Kalpesh M. Parmar, Santosh Kumar, Uttam K. Mete, Shrawan K. Singh, and Arup K. Mandal, Department of Urology, Post Graduate Institute of Medical Education and Research, Chandigarh, India, E-mails: drsudheer1983@gmail.com, vijayantgovinda@gmail.com, ravismi2003@yahoo.com, girdhar2k@gmail.com, aditya.p.sharma@gmail.com, kalpesh010385@gmail.com, santoshsp1967jaimatadi@yahoo.co.in, uttammetepgi@gmail.com, shrawanksingh2002@yahoo.com, and drarupkumar@gmail.com. Nandita Kakkar and Nirmalya Banerjee, Department of Histopathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India, E-mails: nandita_kakkar@yahoo.com and nirmalyapgi@gmail.com. Anup Ghosh, Department of Medical Microbiology, Post Graduate Institute of Medical Education and Research, Chandigarh, India, E-mail: anupkg3@gmail.com. |
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References | Rogenes (b4) 1998; 113 Gupta (b8) 1989; 11 Chakrabarti (b7) 2001; 42 Mignogna (b10) 2011; 15 Dhaliwal (b2) 2015; 385 Cornely (b14) 2014; 20 Pahwa (b6) 2013; 54 Singh (b1) 2014; 2014 Devana (b15) 2016; 32 Gupta (b11) 1999; 14 Chakrabarti (b9) 2013; 7 Chugh (b12) 1993; 22 Gupta (b5) 2012; 5 Paonam (b13) 2014; 2014 Pickles (b3) 1994; 160 |
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Title | Isolated Renal Mucormycosis in Immunocompetent Hosts: Clinical Spectrum and Management Approach |
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