Novel insights on the effect of nicotine in a murine colitis model

• Published in: The Journal of pharmacology and experimental therapeutics Vol. 344; no. 1; pp. 207 - 217
• Main Authors: AlSharari, Shakir D, Akbarali, Hamid I, Abdullah, Rehab A, Shahab, Omer, Auttachoat, Wimolnut, Ferreira, Gabriela A, White, Kimber L, Lichtman, Aron H, Cabral, Guy A, Damaj, M Imad
• Format: Journal Article
• Language: English
• Published: United States The American Society for Pharmacology and Experimental Therapeutics 01.01.2013
• Subjects: Animals; Chromatography, High Pressure Liquid; Colitis, Ulcerative - chemically induced; Colitis, Ulcerative - drug therapy; Colitis, Ulcerative - pathology; Colon - pathology; Cotinine - blood; Cotinine - pharmacology; Dextran Sulfate; Dose-Response Relationship, Drug; Gastrointestinal, Hepatic, Pulmonary, and Renal; Inflammation - pathology; Infusions, Intravenous; Injections, Subcutaneous; Male; Mass Spectrometry; Mice; Mice, Inbred C57BL; Nicotine - administration & dosage; Nicotine - blood; Nicotine - therapeutic use; Nicotinic Agonists - administration & dosage; Nicotinic Agonists - blood; Nicotinic Agonists - therapeutic use; Peroxidase - metabolism; Smoking; Tumor Necrosis Factor-alpha - metabolism

Studies showed that nicotine has a positive influence on symptoms of ulcerative colitis. In the present study, we explored the effect of nicotine treatment using different routes of administration in the dextran sodium sulfate (DSS) colitis mouse model. We also investigated the effects of cotinine,...