Overexpressing lipid raft protein STOML2 modulates the tumor microenvironment via NF-κB signaling in colorectal cancer

• Published in: Cellular and molecular life sciences : CMLS Vol. 81; no. 1; p. 39
• Main Authors: Gong, Hui, Chen, Shaojing, Liu, Shuguang, Hu, Qianying, Li, Yixuan, Li, Yifan, Li, Guiqiu, Huang, Kaimeng, Li, Riqing, Fang, Lishan
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.12.2024; Springer Nature B.V
• Subjects: Angiogenesis; Biochemistry; Biomedical and Life Sciences; Biomedicine; Cancer; CD8 antigen; Cell Biology; Colorectal cancer; Colorectal carcinoma; colorectal neoplasms; Immune evasion; Immunosuppression; Immunotherapy; Inflammation; Life Sciences; Lipids; Lymphocytes; Lymphocytes T; NF-κB protein; Original; Original Article; PD-1 protein; PD-L1 protein; Proteins; Signal transduction; Tumor microenvironment; Tumors; Vascular endothelial growth factor; Angiogenesis; NF-κB; STOML2; Lipid rafts; Tumor microenvironment; Colorectal cancer

Colorectal cancer (CRC) is characterized by a complex tumor inflammatory microenvironment, while angiogenesis and immunosuppression frequently occur concomitantly. However, the exact mechanism that controls angiogenesis and immunosuppression in CRC microenvironment remains unclear. Herein, we found...