Integrated proteomics and metabolomics to evaluate the combined effect of propyl gallate and fumonisin B1 on colon inflammation in vitro and in vivo

• Published in: Ecotoxicology and environmental safety Vol. 300; p. 118440
• Main Authors: Chen, Xiangrong, Dongye, Chenxin, Li, Yan, Zhao, Yanfang, Boukherroub, Rabah, Li, Huijuan, Li, Tianliang, Chen, Xiangfeng
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 15.07.2025; Elsevier
• Subjects: Akr1b8 protein; Animals; Colon - drug effects; Colon - metabolism; Colon - pathology; Colon inflammation; Cytokines - metabolism; Engineering Sciences; Fumonisin B1; Fumonisins - toxicity; Inflammation - chemically induced; Male; Metabolomics; Mice; Physics; Propyl gallate; Propyl Gallate - pharmacology; Propyl Gallate - toxicity; Proteomics; RAW 264.7 Cells; Metabolomics; Colon inflammation; Fumonisin B1; Propyl gallate; Proteomics; Akr1b8 protein

Fumonisin B1 (FB1) is a pervasive hazardous substance in the environment, presenting significant threats to human health and ecological systems. Propyl gallate (PG) is an antioxidant widely used in foods, cosmetics and pharmaceuticals, and its occurrence is an emerging issue in environmental chemist...