Precision medicine: In vivo CAR therapy as a showcase for receptor-targeted vector platforms

• Published in: Molecular therapy Vol. 30; no. 7; pp. 2401 - 2415
• Main Authors: Michels, Alexander, Ho, Naphang, Buchholz, Christian J.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 06.07.2022; American Society of Gene & Cell Therapy
• Subjects: AAV; Animals; Immunotherapy, Adoptive; lentiviral vector; Liposomes; LNP; Mice; nanoparticle; Nanoparticles; off the shelf; Precision Medicine; Receptors, Antigen, T-Cell - genetics; Receptors, Chimeric Antigen - genetics; Review; T lymphocyte; T-Lymphocytes; nanoparticle; T lymphocyte; off the shelf; AAV; lentiviral vector; LNP

Chimeric antigen receptor (CAR) T cells are a cancer immunotherapy of extremes. Unprecedentedly effective, but complex and costly to manufacture, they are not yet a therapeutic option for all who would benefit. This disparity has motivated worldwide efforts to simplify treatment. Among the proposed...