Prevalence of comorbid substance use in schizophrenia spectrum disorders in community and clinical settings, 1990–2017: Systematic review and meta-analysis

• Published in: Drug and alcohol dependence Vol. 191; pp. 234 - 258
• Main Authors: Hunt, Glenn E., Large, Matthew M., Cleary, Michelle, Lai, Harry Man Xiong, Saunders, John B.
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01.10.2018; Elsevier Science Ltd
• Subjects: Adult; Age of onset; Alcohol; Alcoholic beverages; Analysis; Cannabis; Cohort analysis; Cohort Studies; Comorbidity; Dependence; Diagnosis, Dual (Psychiatry); Disorders; Drug abuse; Epidemiology; Evidence-based medicine; Female; Help seeking behavior; Humans; Illicit Drugs; Male; Marijuana; Medical disorders; Medical marijuana; Medical treatment; Mental disorders; Meta-analysis; Patients; Prevalence; Psychosis; Random effects; Regression analysis; Residence Characteristics; Schizophrenia; Schizophrenia - diagnosis; Schizophrenia - epidemiology; Schizophrenic Psychology; Substance use; Substance use disorder; Substance-Related Disorders - diagnosis; Substance-Related Disorders - epidemiology; Substance-Related Disorders - psychology; Systematic review; Substance use; Psychosis; Schizophrenia; Alcohol; Cannabis; Dependence

•This review assessed prevalence of substance use in people with schizophrenia.•The prevalence of any substance use disorder (SUD) was 42%.•Meta-analysis showed substance use was higher in males (48%) than females (22%).•People with SUD had an earlier age of onset of schizophrenia.•Comorbid prevalen...