Mechanism and implications of morphogen shuttling: Lessons learned from dorsal and Cactus in Drosophila

• Published in: Developmental biology Vol. 461; no. 1; pp. 13 - 18
• Main Authors: Schloop, Allison E., Carrell-Noel, Sophia, Friedman, Jeramey, Thomas, Alexander, Reeves, Gregory T.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.2020
• Subjects: Animals; Body Patterning - genetics; Body Patterning - physiology; Cactus; Development; Diffusion; DNA-Binding Proteins - metabolism; Dorsal; Dorsal-ventral axis; Drosophila melanogaster - embryology; Drosophila Proteins - genetics; Drosophila Proteins - metabolism; Embryo; Embryo, Nonmammalian - embryology; Embryonic Development - physiology; I-kappa B Proteins - antagonists & inhibitors; Morphogen; Nuclear Proteins - genetics; Nuclear Proteins - metabolism; Phosphoproteins - genetics; Phosphoproteins - metabolism; Shuttling; Toll; Transcription Factors - genetics; Transcription Factors - metabolism; Embryo; Morphogen; Cactus; Dorsal-ventral axis; Development; Dorsal; Toll; Shuttling; Diffusion

In a developing animal, morphogen gradients act to pattern tissues into distinct domains of cell types. However, despite their prevalence in development, morphogen gradient formation is a matter of debate. In our recent publication, we showed that the Dorsal/NF-κB morphogen gradient, which patterns...