STIM1 calcium sensor is required for activation of the phagocyte oxidase during inflammation and host defense

• Published in: Blood Vol. 123; no. 14; pp. 2238 - 2249
• Main Authors: Zhang, Hong, Clemens, Regina A., Liu, Fengchun, Hu, Yongmei, Baba, Yoshihiro, Theodore, Pierre, Kurosaki, Tomohiro, Lowell, Clifford A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 03.04.2014; American Society of Hematology
• Subjects: Animals; Calcium - metabolism; Calcium Channels; Calcium Signaling - genetics; Cells, Cultured; Enzyme Activation; Immunity - genetics; Inflammation - genetics; Inflammation - metabolism; Liver - pathology; Membrane Glycoproteins - physiology; Mice; Mice, Inbred C57BL; Mice, Knockout; Oxidoreductases - metabolism; Phagocytes - enzymology; Phagocytes, Granulocytes, and Myelopoiesis; Reperfusion Injury - genetics; Reperfusion Injury - metabolism; Stromal Interaction Molecule 1

The stromal-interacting molecule 1 (STIM1) is a potent sensor of intracellular calcium, which in turn regulates entry of external calcium through plasma membrane channels to affect immune cell activation. Although the contribution of STIM1 to calcium signaling in lymphocytes has been well studied, t...