In Situ Raman Study of Neurodegenerated Human Neuroblastoma Cells Exposed to Outer-Membrane Vesicles Isolated from Porphyromonas gingivalis

• Published in: International journal of molecular sciences Vol. 24; no. 17; p. 13351
• Main Authors: Pezzotti, Giuseppe, Adachi, Tetsuya, Imamura, Hayata, Bristol, Davide Redolfi, Adachi, Keiji, Yamamoto, Toshiro, Kanamura, Narisato, Marin, Elia, Zhu, Wenliang, Kawai, Toshihisa, Mazda, Osam, Kariu, Toru, Waku, Tomonori, Nichols, Frank C., Riello, Pietro, Rizzolio, Flavio, Limongi, Tania, Okuma, Kazu
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 28.08.2023; MDPI
• Subjects: Alzheimer's disease; Antibodies; Antigens; Cell culture; Lipids; Metabolism; Neuroblastoma; Pathogens; Toxicity; Transmission electron microscopy; Virulence

The aim of this study was to elucidate the chemistry of cellular degeneration in human neuroblastoma cells upon exposure to outer-membrane vesicles (OMVs) produced by Porphyromonas gingivalis (Pg) oral bacteria by monitoring their metabolomic evolution using in situ Raman spectroscopy. Pg-OMVs are a...