Exercise-induced gene expression changes in skeletal muscle of old mice
Exercise is believed to be beneficial for skeletal muscle functions across all ages. Regimented exercise is often prescribed as an effective treatment/prophylaxis for age-related loss of muscle mass and function, known as sarcopenia, and plays an important role in the maintenance of mobility and fun...
Saved in:
Published in | Genomics (San Diego, Calif.) Vol. 113; no. 5; pp. 2965 - 2976 |
---|---|
Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Elsevier Inc
01.09.2021
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Exercise is believed to be beneficial for skeletal muscle functions across all ages. Regimented exercise is often prescribed as an effective treatment/prophylaxis for age-related loss of muscle mass and function, known as sarcopenia, and plays an important role in the maintenance of mobility and functional independence in the elderly. However, response to exercise declines with aging, resulting in limited gain of muscle strength and endurance. These changes likely reflect age-dependent alterations in transcriptional response underlying the muscular adaptation to exercise. The exact changes in gene expression accompanying exercise, however, are largely unknown, and elucidating them is of a great clinical interest for understanding and optimizing the exercise-based therapies for sarcopenia.
In order to characterize the exercise-induced transcriptomic changes in aged muscle, a paired-end RNA sequencing was performed on rRNA-depleted total RNA extracted from the gastrocnemius muscles of 24 months-old mice after 8 weeks of regimented exercise (exercise group) or no formal exercise program (sedentary group).
Differential gene expression analysis of aged skeletal muscle revealed upregulations in the group of genes involved in neurotransmission and neuroexcitation, as well as equally notable absence of anabolic gene upregulations in the exercise group. In particular, genes encoding the transporters and receptor components of glutaminergic transmission were significantly upregulated in exercised muscles, as exemplified by Gria 1, Gria 2 and Grin2c encoding glutamate receptor 1, 2 and 2C respectively, Grin1 and Grin2b encoding N-methyl-d-aspartate receptors (NMDARs), Nptx1 responsible for glutaminergic receptor clustering, and Slc1a2 and Slc17a7 regulating synaptic uptake of glutamate. These changes were accompanied by an increase in the post-synaptic density of NMDARs and acetylcholine receptors (AChRs), as well as their innervation at neuromuscular junctions (NMJs).
These results suggest that neural responses predominate the adaptive response of aged skeletal muscle to exercise, and indicate a possibility that glutaminergic transmission at NMJs may be present and responsible for synaptic protection and neural remodeling accompanying the exercise-induced functional enhancement in aged skeletal muscle. In addition, the absence of upregulations in the anabolic pathways highlights them as the area of potential pharmacological targeting for optimizing exercise-led sarcopenia therapy.
•Response to exercise declines with aging, with a limited gain of muscle strength and endurance.•These changes likely reflect age-dependent alterations in transcriptional response underlying muscle adaptation to exercise.•Differential gene expression analysis of aged skeletal muscle revealed upregulations in genes involved in neurotransmission.•Transcriptional changes were accompanied by an increase in the post-synaptic density of NMDARs and AChRs. |
---|---|
AbstractList | Exercise is believed to be beneficial for skeletal muscle functions across all ages. Regimented exercise is often prescribed as an effective treatment/prophylaxis for age-related loss of muscle mass and function, known as sarcopenia, and plays an important role in the maintenance of mobility and functional independence in the elderly. However, response to exercise declines with aging, resulting in limited gain of muscle strength and endurance. These changes likely reflect age-dependent alterations in transcriptional response underlying the muscular adaptation to exercise. The exact changes in gene expression accompanying exercise, however, are largely unknown, and elucidating them is of a great clinical interest for understanding and optimizing the exercise-based therapies for sarcopenia.
In order to characterize the exercise-induced transcriptomic changes in aged muscle, a paired-end RNA sequencing was performed on rRNA-depleted total RNA extracted from the gastrocnemius muscles of 24 months-old mice after 8 weeks of regimented exercise (exercise group) or no formal exercise program (sedentary group).
Differential gene expression analysis of aged skeletal muscle revealed upregulations in the group of genes involved in neurotransmission and neuroexcitation, as well as equally notable absence of anabolic gene upregulations in the exercise group. In particular, genes encoding the transporters and receptor components of glutaminergic transmission were significantly upregulated in exercised muscles, as exemplified by Gria 1, Gria 2 and Grin2c encoding glutamate receptor 1, 2 and 2C respectively, Grin1 and Grin2b encoding N-methyl-d-aspartate receptors (NMDARs), Nptx1 responsible for glutaminergic receptor clustering, and Slc1a2 and Slc17a7 regulating synaptic uptake of glutamate. These changes were accompanied by an increase in the post-synaptic density of NMDARs and acetylcholine receptors (AChRs), as well as their innervation at neuromuscular junctions (NMJs).
These results suggest that neural responses predominate the adaptive response of aged skeletal muscle to exercise, and indicate a possibility that glutaminergic transmission at NMJs may be present and responsible for synaptic protection and neural remodeling accompanying the exercise-induced functional enhancement in aged skeletal muscle. In addition, the absence of upregulations in the anabolic pathways highlights them as the area of potential pharmacological targeting for optimizing exercise-led sarcopenia therapy.
•Response to exercise declines with aging, with a limited gain of muscle strength and endurance.•These changes likely reflect age-dependent alterations in transcriptional response underlying muscle adaptation to exercise.•Differential gene expression analysis of aged skeletal muscle revealed upregulations in genes involved in neurotransmission.•Transcriptional changes were accompanied by an increase in the post-synaptic density of NMDARs and AChRs. Exercise is believed to be beneficial for skeletal muscle functions across all ages. Regimented exercise is often prescribed as an effective treatment/prophylaxis for age-related loss of muscle mass and functions known as sarcopenia, and plays an important role in the maintenance of mobility and functional independence in the elderly. However, response to exercise changes with aging, with a shift from a predominantly anabolic response resulting in limited gain of muscle strength and endurance. These changes likely reflect age-dependent alterations in transcriptional response underlying the muscular adaptation to exercise. The exact changes in gene expression accompanying exercise, however, are largely unknown, and elucidating them is of a great clinical interest for understanding and optimizing the exercise-based therapies for sarcopenia. In order to characterize the exercise-induced transcriptomic changes in aged muscle, a paired-end RNA sequencing was performed on the rRNA-depleted total RNA extracted from the gastrocnemius muscles of 24 months-old mice after 8 weeks of regimented exercise (exercise group) or no formal exercise program (sedentary group). Differential gene expression analysis of aged skeletal muscle revealed upregulations in the group of genes involved in neurotransmission and neuroexcitation, as well as equally notable absence of anabolic gene upregulations in the exercised group. In particular, genes encoding the transporters and receptor components of glutaminergic transmission were significantly upregulated in exercised muscles, as exemplified by Gria 1, Gria 2 and Grin2c encoding glutamate receptor 1, 2 and 2C respectively, Grin1 and Grin2b encoding N-methyl-D-aspartate receptors (NMDARs), Nptx1 responsible for glutaminergic receptor clustering, and Slc1a2 and Slc17a7 regulating synaptic uptake of glutamate. These changes were accompanied by an increase in the post-synaptic density of NMDARs and acetylcholine receptors (AChRs), as well as their innervation at neuromuscular junctions (NMJs). These results suggest that neural responses predominate the adaptive response of aged skeletal muscle to exercise, and indicate a possibility that glutaminergic transmission at NMJs may be present and responsible for synaptic protection and neural remodeling accompanying the exercise-induced functional enhancement in aged skeletal muscle. In addition, the absence of upregulations in the anabolic pathways highlights them as the area of potential pharmacological targeting for optimizing exercise-led sarcopenia therapy. Exercise is believed to be beneficial for skeletal muscle functions across all ages. Regimented exercise is often prescribed as an effective treatment/prophylaxis for age-related loss of muscle mass and function, known as sarcopenia, and plays an important role in the maintenance of mobility and functional independence in the elderly. However, response to exercise declines with aging, resulting in limited gain of muscle strength and endurance. These changes likely reflect age-dependent alterations in transcriptional response underlying the muscular adaptation to exercise. The exact changes in gene expression accompanying exercise, however, are largely unknown, and elucidating them is of a great clinical interest for understanding and optimizing the exercise-based therapies for sarcopenia. In order to characterize the exercise-induced transcriptomic changes in aged muscle, a paired-end RNA sequencing was performed on rRNA-depleted total RNA extracted from the gastrocnemius muscles of 24 months-old mice after 8 weeks of regimented exercise (exercise group) or no formal exercise program (sedentary group). Differential gene expression analysis of aged skeletal muscle revealed upregulations in the group of genes involved in neurotransmission and neuroexcitation, as well as equally notable absence of anabolic gene upregulations in the exercise group. In particular, genes encoding the transporters and receptor components of glutaminergic transmission were significantly upregulated in exercised muscles, as exemplified by Gria 1, Gria 2 and Grin2c encoding glutamate receptor 1, 2 and 2C respectively, Grin1 and Grin2b encoding N-methyl-d-aspartate receptors (NMDARs), Nptx1 responsible for glutaminergic receptor clustering, and Slc1a2 and Slc17a7 regulating synaptic uptake of glutamate. These changes were accompanied by an increase in the post-synaptic density of NMDARs and acetylcholine receptors (AChRs), as well as their innervation at neuromuscular junctions (NMJs). These results suggest that neural responses predominate the adaptive response of aged skeletal muscle to exercise, and indicate a possibility that glutaminergic transmission at NMJs may be present and responsible for synaptic protection and neural remodeling accompanying the exercise-induced functional enhancement in aged skeletal muscle. In addition, the absence of upregulations in the anabolic pathways highlights them as the area of potential pharmacological targeting for optimizing exercise-led sarcopenia therapy. |
Author | Olumi, Shayan Argawal, Shailesh Endo, Yori Neppl, Ronald L. Sinha, Indranil Zhang, Yuteng Karvar, Mehran |
AuthorAffiliation | 3 Department of Biology, Northwestern University, Evanston, IL 1 Division of Plastic Surgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 4 Department of Orthopedic Surgery, Brigham and Women’s Hospital, Boston, MA 2 Department of Plastic and Aesthetic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China 5 Harvard Department of Stem Cell and Regenerative Biology and Harvard Stem Cell Institute, Cambridge, MA |
AuthorAffiliation_xml | – name: 4 Department of Orthopedic Surgery, Brigham and Women’s Hospital, Boston, MA – name: 2 Department of Plastic and Aesthetic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China – name: 3 Department of Biology, Northwestern University, Evanston, IL – name: 5 Harvard Department of Stem Cell and Regenerative Biology and Harvard Stem Cell Institute, Cambridge, MA – name: 1 Division of Plastic Surgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA |
Author_xml | – sequence: 1 givenname: Yori surname: Endo fullname: Endo, Yori organization: Division of Plastic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States – sequence: 2 givenname: Yuteng surname: Zhang fullname: Zhang, Yuteng organization: Division of Plastic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States – sequence: 3 givenname: Shayan surname: Olumi fullname: Olumi, Shayan organization: Division of Plastic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States – sequence: 4 givenname: Mehran surname: Karvar fullname: Karvar, Mehran organization: Division of Plastic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States – sequence: 5 givenname: Shailesh surname: Argawal fullname: Argawal, Shailesh organization: Division of Plastic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States – sequence: 6 givenname: Ronald L. surname: Neppl fullname: Neppl, Ronald L. organization: Department of Orthopedic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA – sequence: 7 givenname: Indranil surname: Sinha fullname: Sinha, Indranil email: isinha@bwh.harvard.edu organization: Division of Plastic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/34214629$$D View this record in MEDLINE/PubMed |
BookMark | eNp9Uctu2zAQJAoHjfP4ggABj71I4UsUeWiBwnDTAAZyac-ERK0cOhLpklIQ_32ZOgnaS08L7M7OzO6coYUPHhC6oqSkhMqbXXnYgg8lI4yWRJaEVx_QkhKlCyWFXKAlUUoVdSX4KTpLaUcI0Vyxj-iUC0aFZHqJbtfPEK1LUDjfzRY6nDkBw_M-QkoueGwfGr-FhJ3H6REGmJoBj3OyA-DQ4zB0eHQWLtBJ3wwJLl_rOfr5bf1j9b3Y3N_erb5uCisqPRU1g5qLnmklVK-F5ES1fWW11RRsq3vFpRK04cRmK6ISXVe3uWkldLatesbP0Zcj735ux9wEP8VmMPvoxiYeTGic-Xfi3YPZhiejBOFZLhN8eiWI4dcMaTKjSxaGofEQ5mRYJbIDKmidofwItTGkFKF_l6HEvERgduZPBOYlAkOkyRHkreu_Hb7vvP08Az4fAZD_9OQgmmQd-Hywi2An0wX3X4HfZy6cQg |
CitedBy_id | crossref_primary_10_1038_s41598_022_25758_2 crossref_primary_10_1016_j_intimp_2024_111964 crossref_primary_10_1007_s12264_023_01128_4 crossref_primary_10_1016_j_toxrep_2022_07_002 crossref_primary_10_1016_j_jot_2024_03_007 crossref_primary_10_1093_gerona_glae144 crossref_primary_10_3390_ijms24032736 crossref_primary_10_3389_fphys_2023_1280553 crossref_primary_10_1016_j_cyto_2021_155746 |
Cites_doi | 10.3389/fimmu.2018.00648 10.1152/japplphysiol.01295.2009 10.1249/MSS.0b013e3181e0b9a8 10.1111/j.1460-9568.2004.03628.x 10.1093/nar/gkx356 10.1371/journal.pone.0051066 10.1096/fj.09-150177 10.1186/s42826-019-0035-8 10.1097/00005768-200104000-00021 10.1152/japplphysiol.00634.2010 10.1073/pnas.1002220107 10.1007/BF00190144 10.1002/cphy.c100074 10.1113/jphysiol.2008.164483 10.1093/gerona/51A.6.M270 10.1152/japplphysiol.01474.2005 10.1152/japplphysiol.00909.2013 10.1172/JCI117731 10.1152/japplphysiol.01366.2013 10.1038/s41598-019-42203-z 10.1371/journal.pgen.1006294 10.1186/s13059-014-0550-8 10.1073/pnas.1809050115 10.1002/mus.21099 10.1096/fj.202000761RR 10.1249/mss.0b013e31815bbba9 10.1155/2015/957598 10.1152/japplphysiol.00435.2011 10.1523/JNEUROSCI.1181-16.2016 10.1186/1471-2164-11-659 10.1046/j.1474-9728.2003.00011.x 10.1093/bioinformatics/btt656 10.3390/ijms20163956 10.3389/fphys.2020.00874 10.1093/bioinformatics/bts635 |
ContentType | Journal Article |
Copyright | 2021 Elsevier Inc. Copyright © 2021 Elsevier Inc. All rights reserved. |
Copyright_xml | – notice: 2021 Elsevier Inc. – notice: Copyright © 2021 Elsevier Inc. All rights reserved. |
DBID | 6I. AAFTH CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 5PM |
DOI | 10.1016/j.ygeno.2021.06.035 |
DatabaseName | ScienceDirect Open Access Titles Elsevier:ScienceDirect:Open Access Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef MEDLINE - Academic PubMed Central (Full Participant titles) |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef MEDLINE - Academic |
DatabaseTitleList | MEDLINE |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Engineering Chemistry Biology |
EISSN | 1089-8646 |
EndPage | 2976 |
ExternalDocumentID | 10_1016_j_ygeno_2021_06_035 34214629 S0888754321002524 |
Genre | Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural |
GrantInformation_xml | – fundername: NIA NIH HHS grantid: K76 AG059996 – fundername: NIA NIH HHS grantid: P30 AG031679 |
GroupedDBID | --- --K --M -DZ -~X .55 .GJ .~1 0R~ 0SF 1B1 1RT 1~. 1~5 29H 4.4 457 4G. 53G 5GY 5VS 6I. 7-5 71M 8P~ 9JM AACTN AAEDT AAEDW AAFTH AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AAXUO AAYOK ABEFU ABFNM ABFRF ABGSF ABJNI ABLJU ABMAC ABUDA ABVKL ABXDB ABYKQ ACDAQ ACGFO ACGFS ACRLP ADBBV ADEZE ADFGL ADMUD ADUVX AEBSH AEFWE AEHWI AEKER AENEX AEXQZ AFKWA AFTJW AFXIZ AGHFR AGRDE AGUBO AGYEJ AHHHB AHPSJ AI. AIEXJ AIKHN AITUG AJBFU AJOXV ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ AXJTR BAWUL BKOJK BLXMC CAG COF CS3 DIK DM4 DOVZS DU5 E3Z EBS EFBJH EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA GROUPED_DOAJ HLW HVGLF HZ~ IHE IXB J1W K-O KOM L7B LG5 LX2 M41 MO0 N9A NCXOZ O-L O9- OAUVE OK1 OZT P-8 P-9 P2P PC. Q38 RIG ROL RPZ SBG SCC SDF SDG SDP SES SEW SPCBC SSU SSZ T5K TN5 TR2 VH1 WUQ X7M XPP XSW ZA5 ZGI ZMT ZU3 ZXP ~G- ~KM AAHBH AAXKI ADVLN AFJKZ AKRWK CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 5PM |
ID | FETCH-LOGICAL-c459t-72e734f29848f946308bf5c9c91ecb9f836841a30cced454dd7bf83c6edcb5f23 |
IEDL.DBID | IXB |
ISSN | 0888-7543 |
IngestDate | Tue Sep 17 21:25:29 EDT 2024 Fri Aug 16 07:19:58 EDT 2024 Thu Sep 26 17:53:33 EDT 2024 Sat Sep 28 08:22:10 EDT 2024 Fri Feb 23 02:38:41 EST 2024 |
IsDoiOpenAccess | true |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 5 |
Keywords | Aging Sarcopenia Differentially expressed genes Exercise Skeletal muscle |
Language | English |
License | This article is made available under the Elsevier license. Copyright © 2021 Elsevier Inc. All rights reserved. |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c459t-72e734f29848f946308bf5c9c91ecb9f836841a30cced454dd7bf83c6edcb5f23 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Yori Endo: Methodology, Writing, Reviewing and Editing, Software Yuteng Zhang: Data curation, Writing- Original draft preparation. Shayan Olumi: Visualization, Data curation Mehran Karvar: Software Shailesh Argawal: Supervision Ronald L. Neppl: Supervision, Conceptualization Indranil Sinha: Conceptualization, Writing- Reviewing and Editing. Shailesh |
OpenAccessLink | https://www.sciencedirect.com/science/article/pii/S0888754321002524 |
PMID | 34214629 |
PQID | 2548411417 |
PQPubID | 23479 |
PageCount | 12 |
ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_8403630 proquest_miscellaneous_2548411417 crossref_primary_10_1016_j_ygeno_2021_06_035 pubmed_primary_34214629 elsevier_sciencedirect_doi_10_1016_j_ygeno_2021_06_035 |
PublicationCentury | 2000 |
PublicationDate | 2021-09-01 |
PublicationDateYYYYMMDD | 2021-09-01 |
PublicationDate_xml | – month: 09 year: 2021 text: 2021-09-01 day: 01 |
PublicationDecade | 2020 |
PublicationPlace | United States |
PublicationPlace_xml | – name: United States |
PublicationTitle | Genomics (San Diego, Calif.) |
PublicationTitleAlternate | Genomics |
PublicationYear | 2021 |
Publisher | Elsevier Inc |
Publisher_xml | – name: Elsevier Inc |
References | Delbono (bb0100) 2003; 2 Hood, Uguccioni, Vainshtein, Dsouza (bb0140) 2011 Bertuzzi, Chang, Ampatzis (bb0170) 2018; 115 Endo, Nourmahnad, Sinha (bb0155) 2020; 11 Campbell, Turner (bb0030) 2018; 9 Nader, von Walden, Liu (bb0075) 2014; 116 Liao, Smyth, Shi (bb0120) 2013; 30 Damirchi, Babaei, Gholamali, Ranjbar (bb0145) 2012 Neubauer, Sabapathy, Ashton (bb0080) 2014; 116 Raue, Trappe, Estrem (bb0085) 2012; 112 Wang, Vasaikar, Shi, Greer, Zhang (bb0130) 2017; 45 Personius, Slusher, Udin (bb0185) 2016; 36 Kosek, Kim, Petrella, Cross, Bamman (bb0045) 2006; 101 Zelikovich, Quattrocelli, Salamone, Kuntz, McNally (bb0105) 2019 Valdez, Tapia, Kang (bb0095) 2010; 107 Kim, Kim, Lee, Seong (bb0110) 2020 Hawkins, Foster-Schubert, Chubak (bb0020) 2008; 40 Love, Huber, Anders (bb0125) 2014; 15 Endo, Baldino, Li, Sakthivel, MacArthur, Panayi Adriana, Kip, Spencer Daniel, Jasuja, Bagchi, Bhasin, Nuutila, Neppl Ronald, Wagers Amy, Sinha (bb5000) 2020 Mays, Sanford, Hanada, Chishti, Rafael-Fortney (bb0165) 2009; 39 Bresler, Vogel, Niederer, Gray, Schmitz-Rixen, Troidl (bb0135) 2019 Benton (bb0005) 2015 Waerhaug, Ottersen (bb0175) 1993; 188 Lindholm, Giacomello, Werne Solnestam (bb0050) 2016; 12 Borst, De Hoyos, Garzarella, Vincent, Pollack, Lowenthal (bb0015) 2001; 33 Hittel, Axelson, Sarna, Shearer, Huffman, Kraus (bb0025) 2010; 42 Timmons, Knudsen, Rankinen, Koch, Sarzynski, Jensen, Keller, Scheele, Vollaard, Nielsen, Akerström, MacDougald, Jansson, Greenhaff, Tarnopolsky, van Loon, Pedersen, Sundberg, Wahlestedt, Britton, Bouchard (bb0060) 2010; 108 Alvarez, Kirchner, Chu, Smith, Winnick-Baskin, Mielenz (bb0190) 2015; 2015 Welle, Totterman, Thornton (bb0040) 1996; 51 Kumar, Selby, Rankin, Patel, Atherton, Hildebrandt (bb0035) 2009; 587 Mccartney, Hicks, Martin, Webber (bb0150) 1995; 50A Julien, Sephton, Dutchak (bb0160) 2018 Biolo, Declan Fleming, Wolfe (bb0010) 1995; 95 Keller, Vollaard, Gustafsson, Gallagher, Sundberg, Rankinen (bb0055) 2011; 110 Catoire, Mensink, Boekschoten, Hangelbroek, Muller, Schrauwen, Kersten (bb0070) 2012; 7 Durham, Casperson, Dillon (bb0090) 2010; 24 Dobin, Davis, Schlesinger, Drenkow, Zaleski, Jha, Batut, Chaisson, Gingeras (bb0115) 2012; 29 Liu, Sartor, Nader (bb0065) 2010; 11 Herzog, Landry, Buhler, Bouali-Benazzouz, Legay, Henderson, Nagy, Dreyfus, Giros, Mestikawy (bb0180) 2004; 20 Benton (10.1016/j.ygeno.2021.06.035_bb0005) 2015 Kumar (10.1016/j.ygeno.2021.06.035_bb0035) 2009; 587 Hood (10.1016/j.ygeno.2021.06.035_bb0140) 2011 Valdez (10.1016/j.ygeno.2021.06.035_bb0095) 2010; 107 Personius (10.1016/j.ygeno.2021.06.035_bb0185) 2016; 36 Nader (10.1016/j.ygeno.2021.06.035_bb0075) 2014; 116 Neubauer (10.1016/j.ygeno.2021.06.035_bb0080) 2014; 116 Damirchi (10.1016/j.ygeno.2021.06.035_bb0145) 2012 Mccartney (10.1016/j.ygeno.2021.06.035_bb0150) 1995; 50A Bertuzzi (10.1016/j.ygeno.2021.06.035_bb0170) 2018; 115 Liu (10.1016/j.ygeno.2021.06.035_bb0065) 2010; 11 Zelikovich (10.1016/j.ygeno.2021.06.035_bb0105) 2019 Love (10.1016/j.ygeno.2021.06.035_bb0125) 2014; 15 Biolo (10.1016/j.ygeno.2021.06.035_bb0010) 1995; 95 Kosek (10.1016/j.ygeno.2021.06.035_bb0045) 2006; 101 Waerhaug (10.1016/j.ygeno.2021.06.035_bb0175) 1993; 188 Timmons (10.1016/j.ygeno.2021.06.035_bb0060) 2010; 108 Campbell (10.1016/j.ygeno.2021.06.035_bb0030) 2018; 9 Raue (10.1016/j.ygeno.2021.06.035_bb0085) 2012; 112 Bresler (10.1016/j.ygeno.2021.06.035_bb0135) 2019 Catoire (10.1016/j.ygeno.2021.06.035_bb0070) 2012; 7 Alvarez (10.1016/j.ygeno.2021.06.035_bb0190) 2015; 2015 Dobin (10.1016/j.ygeno.2021.06.035_bb0115) 2012; 29 Hawkins (10.1016/j.ygeno.2021.06.035_bb0020) 2008; 40 Lindholm (10.1016/j.ygeno.2021.06.035_bb0050) 2016; 12 Herzog (10.1016/j.ygeno.2021.06.035_bb0180) 2004; 20 Keller (10.1016/j.ygeno.2021.06.035_bb0055) 2011; 110 Durham (10.1016/j.ygeno.2021.06.035_bb0090) 2010; 24 Mays (10.1016/j.ygeno.2021.06.035_bb0165) 2009; 39 Borst (10.1016/j.ygeno.2021.06.035_bb0015) 2001; 33 Welle (10.1016/j.ygeno.2021.06.035_bb0040) 1996; 51 Kim (10.1016/j.ygeno.2021.06.035_bb0110) 2020 Julien (10.1016/j.ygeno.2021.06.035_bb0160) 2018 Wang (10.1016/j.ygeno.2021.06.035_bb0130) 2017; 45 Liao (10.1016/j.ygeno.2021.06.035_bb0120) 2013; 30 Hittel (10.1016/j.ygeno.2021.06.035_bb0025) 2010; 42 Delbono (10.1016/j.ygeno.2021.06.035_bb0100) 2003; 2 Endo (10.1016/j.ygeno.2021.06.035_bb0155) 2020; 11 Endo (10.1016/j.ygeno.2021.06.035_bb5000) 2020 |
References_xml | – volume: 20 start-page: 1752 year: 2004 end-page: 1760 ident: bb0180 article-title: Expression of vesicular glutamate transporters, VGLUT1 and VGLUT2, in cholinergic spinal motoneurons publication-title: Eur. J. Neurosci. contributor: fullname: Mestikawy – volume: 9 start-page: 648 year: 2018 ident: bb0030 article-title: Debunking the myth of exercise-induced immune suppression: redefining the impact of exercise on immunological health across the lifespan publication-title: Front. Immunol. contributor: fullname: Turner – volume: 116 start-page: 274 year: 2014 end-page: 287 ident: bb0080 article-title: Time course-dependent changes in the transcriptome of human skeletal muscle during recovery from endurance exercise: from inflammation to adaptive remodeling publication-title: J. Appl. Physiol. (1985) contributor: fullname: Ashton – volume: 115 year: 2018 ident: bb0170 article-title: Adult spinal motoneurons change their neurotransmitter phenotype to control locomotion publication-title: Proc. Natl. Acad. Sci. contributor: fullname: Ampatzis – volume: 30 start-page: 923 year: 2013 end-page: 930 ident: bb0120 article-title: featureCounts: an efficient general purpose program for assigning sequence reads to genomic features publication-title: Bioinformatics contributor: fullname: Shi – volume: 11 year: 2020 ident: bb0155 article-title: Optimizing skeletal muscle anabolic response to resistance training in aging publication-title: Front. Physiol. contributor: fullname: Sinha – volume: 51 start-page: M270 year: 1996 end-page: M275 ident: bb0040 article-title: Effect of age on muscle hypertrophy induced by resistance training publication-title: J. Gerontol. A Biol. Sci. Med. Sci. contributor: fullname: Thornton – year: 2011 ident: bb0140 article-title: Mechanisms of exercise-induced mitochondrial biogenesis in skeletal muscle: implications for health and disease publication-title: Comprehen. Physiol. contributor: fullname: Dsouza – year: 2020 ident: bb5000 article-title: Loss of ARNT in skeletal muscle limits muscle regeneration in aging publication-title: The FASEB Journal contributor: fullname: Sinha – volume: 587 start-page: 211 year: 2009 end-page: 217 ident: bb0035 article-title: Age-related differences in the dose-response relationship of muscle protein synthesis to resistance exercise in young and old men publication-title: J. Physiol. contributor: fullname: Hildebrandt – volume: 95 start-page: 811 year: 1995 end-page: 819 ident: bb0010 article-title: Physiologic hyperinsulinemia stimulates protein synthesis and enhances transport of selected amino acids in human skeletal muscle publication-title: J. Clin. Invest. contributor: fullname: Wolfe – volume: 2 start-page: 21 year: 2003 end-page: 29 ident: bb0100 article-title: Neural control of aging skeletal muscle publication-title: Aging Cell contributor: fullname: Delbono – volume: 45 year: 2017 ident: bb0130 article-title: WebGestalt 2017: a more comprehensive, powerful, flexible and interactive gene set enrichment analysis toolkit publication-title: Nucleic Acids Res. contributor: fullname: Zhang – start-page: 13 year: 2015 end-page: 27 ident: bb0005 article-title: Benefits of exercise for older adults publication-title: Exercise for Aging Adults contributor: fullname: Benton – volume: 36 start-page: 8783 year: 2016 end-page: 8789 ident: bb0185 article-title: Neuromuscular NMDA receptors modulate developmental synapse elimination publication-title: J. Neurosci. contributor: fullname: Udin – volume: 110 start-page: 46 year: 2011 end-page: 59 ident: bb0055 article-title: A transcriptional map of the impact of endurance exercise training on skeletal muscle phenotype publication-title: J. Appl. Physiol. (1985) contributor: fullname: Rankinen – volume: 40 start-page: 223 year: 2008 end-page: 233 ident: bb0020 article-title: Effect of exercise on serum sex hormones in men: a 12-month randomized clinical trial publication-title: Med. Sci. Sports Exerc. contributor: fullname: Chubak – volume: 11 start-page: 659 year: 2010 ident: bb0065 article-title: Skeletal muscle gene expression in response to resistance exercise: sex specific regulation publication-title: BMC Genomics contributor: fullname: Nader – volume: 7 year: 2012 ident: bb0070 article-title: Pronounced effects of acute endurance exercise on gene expression in resting and exercising human skeletal muscle publication-title: PLoS One contributor: fullname: Kersten – volume: 33 start-page: 648 year: 2001 end-page: 653 ident: bb0015 article-title: Effects of resistance training on insulin-like growth factor-I and IGF binding proteins publication-title: Medand Sci. Sports Exer. contributor: fullname: Lowenthal – volume: 42 start-page: 2023 year: 2010 end-page: 2029 ident: bb0025 article-title: Myostatin decreases with aerobic exercise and associates with insulin resistance publication-title: Med. Sci. Sports Exerc. contributor: fullname: Kraus – volume: 12 year: 2016 ident: bb0050 article-title: The impact of endurance training on human skeletal muscle memory, global isoform expression and novel transcripts publication-title: PLoS Genet. contributor: fullname: Werne Solnestam – volume: 108 start-page: 1487 year: 2010 end-page: 1496 ident: bb0060 article-title: Using molecular classification to predict gains in maximal aerobic capacity following endurance exercise training in humans publication-title: J. Appl. Physiol. (1985) contributor: fullname: Bouchard – volume: 2015 start-page: 1 year: 2015 end-page: 4 ident: bb0190 article-title: Falls reduction and exercise training in an assisted living population publication-title: J. Aging Res. contributor: fullname: Mielenz – volume: 15 year: 2014 ident: bb0125 article-title: Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 publication-title: Genome Biol. contributor: fullname: Anders – year: 2019 ident: bb0105 article-title: Moderate exercise improves function and increases adiponectin in the mdx mouse model of muscular dystrophy publication-title: Sci. Rep. contributor: fullname: McNally – volume: 50A year: 1995 ident: bb0150 article-title: Long-term resistance training in the elderly: effects on dynamic strength, exercise capacity, muscle, and bone publication-title: J. Gerontol. Ser. A Biol. Med. Sci. contributor: fullname: Webber – volume: 188 year: 1993 ident: bb0175 article-title: Demonstration of glutamate-like immunoreactivity at rat neuromuscular junctions by quantitative electron microscopic immunocytochemistry publication-title: Anat. Embryol. contributor: fullname: Ottersen – volume: 107 start-page: 14863 year: 2010 end-page: 14868 ident: bb0095 article-title: Attenuation of age-related changes in mouse neuromuscular synapses by caloric restriction and exercise publication-title: Proc. Natl. Acad. Sci. U. S. A. contributor: fullname: Kang – year: 2019 ident: bb0135 article-title: Development of an exercise training protocol to investigate arteriogenesis in a murine model of peripheral artery disease publication-title: Int. J. Mol. Sci. contributor: fullname: Troidl – volume: 39 start-page: 343 year: 2009 end-page: 349 ident: bb0165 article-title: Glutamate receptors localize postsynaptically at neuromuscular junctions in mice publication-title: Muscle Nerve contributor: fullname: Rafael-Fortney – volume: 116 start-page: 693 year: 2014 end-page: 702 ident: bb0075 article-title: Resistance exercise training modulates acute gene expression during human skeletal muscle hypertrophy publication-title: J. Appl. Physiol. (1985) contributor: fullname: Liu – year: 2012 ident: bb0145 article-title: Mitochondrial biogenesis in skeletal muscle: exercise and aging publication-title: Skeletal Muscle - From Myogenesis to Clinical Relations contributor: fullname: Ranjbar – year: 2020 ident: bb0110 article-title: A comparison of the metabolic effects of treadmill and wheel running exercise in mouse model publication-title: Lab Anim. Res. contributor: fullname: Seong – volume: 101 start-page: 531 year: 2006 end-page: 544 ident: bb0045 article-title: Efficacy of 3 days/wk resistance training on myofiber hypertrophy and myogenic mechanisms in young vs. older adults publication-title: J. Appl. Physiol. contributor: fullname: Bamman – volume: 112 start-page: 1625 year: 2012 end-page: 1636 ident: bb0085 article-title: Transcriptome signature of resistance exercise adaptations: mixed muscle and fiber type specific profiles in young and old adults publication-title: J. Appl. Physiol. (1985) contributor: fullname: Estrem – volume: 24 start-page: 4117 year: 2010 end-page: 4127 ident: bb0090 article-title: Age-related anabolic resistance after endurance-type exercise in healthy humans publication-title: FASEB J. contributor: fullname: Dillon – year: 2018 ident: bb0160 article-title: Metabolic networks influencing skeletal muscle fiber composition publication-title: Front. Cell. Dev. Biol. contributor: fullname: Dutchak – volume: 29 start-page: 15 year: 2012 end-page: 21 ident: bb0115 article-title: STAR: ultrafast universal RNA-seq aligner publication-title: Bioinformatics contributor: fullname: Gingeras – volume: 9 start-page: 648 year: 2018 ident: 10.1016/j.ygeno.2021.06.035_bb0030 article-title: Debunking the myth of exercise-induced immune suppression: redefining the impact of exercise on immunological health across the lifespan publication-title: Front. Immunol. doi: 10.3389/fimmu.2018.00648 contributor: fullname: Campbell – volume: 108 start-page: 1487 issue: 6 year: 2010 ident: 10.1016/j.ygeno.2021.06.035_bb0060 article-title: Using molecular classification to predict gains in maximal aerobic capacity following endurance exercise training in humans publication-title: J. Appl. Physiol. (1985) doi: 10.1152/japplphysiol.01295.2009 contributor: fullname: Timmons – volume: 42 start-page: 2023 year: 2010 ident: 10.1016/j.ygeno.2021.06.035_bb0025 article-title: Myostatin decreases with aerobic exercise and associates with insulin resistance publication-title: Med. Sci. Sports Exerc. doi: 10.1249/MSS.0b013e3181e0b9a8 contributor: fullname: Hittel – volume: 20 start-page: 1752 year: 2004 ident: 10.1016/j.ygeno.2021.06.035_bb0180 article-title: Expression of vesicular glutamate transporters, VGLUT1 and VGLUT2, in cholinergic spinal motoneurons publication-title: Eur. J. Neurosci. doi: 10.1111/j.1460-9568.2004.03628.x contributor: fullname: Herzog – volume: 45 year: 2017 ident: 10.1016/j.ygeno.2021.06.035_bb0130 article-title: WebGestalt 2017: a more comprehensive, powerful, flexible and interactive gene set enrichment analysis toolkit publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkx356 contributor: fullname: Wang – volume: 7 issue: 11 year: 2012 ident: 10.1016/j.ygeno.2021.06.035_bb0070 article-title: Pronounced effects of acute endurance exercise on gene expression in resting and exercising human skeletal muscle publication-title: PLoS One doi: 10.1371/journal.pone.0051066 contributor: fullname: Catoire – volume: 24 start-page: 4117 issue: 10 year: 2010 ident: 10.1016/j.ygeno.2021.06.035_bb0090 article-title: Age-related anabolic resistance after endurance-type exercise in healthy humans publication-title: FASEB J. doi: 10.1096/fj.09-150177 contributor: fullname: Durham – start-page: 13 year: 2015 ident: 10.1016/j.ygeno.2021.06.035_bb0005 article-title: Benefits of exercise for older adults contributor: fullname: Benton – year: 2020 ident: 10.1016/j.ygeno.2021.06.035_bb0110 article-title: A comparison of the metabolic effects of treadmill and wheel running exercise in mouse model publication-title: Lab Anim. Res. doi: 10.1186/s42826-019-0035-8 contributor: fullname: Kim – volume: 33 start-page: 648 year: 2001 ident: 10.1016/j.ygeno.2021.06.035_bb0015 article-title: Effects of resistance training on insulin-like growth factor-I and IGF binding proteins publication-title: Medand Sci. Sports Exer. doi: 10.1097/00005768-200104000-00021 contributor: fullname: Borst – volume: 110 start-page: 46 issue: 1 year: 2011 ident: 10.1016/j.ygeno.2021.06.035_bb0055 article-title: A transcriptional map of the impact of endurance exercise training on skeletal muscle phenotype publication-title: J. Appl. Physiol. (1985) doi: 10.1152/japplphysiol.00634.2010 contributor: fullname: Keller – volume: 107 start-page: 14863 issue: 33 year: 2010 ident: 10.1016/j.ygeno.2021.06.035_bb0095 article-title: Attenuation of age-related changes in mouse neuromuscular synapses by caloric restriction and exercise publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.1002220107 contributor: fullname: Valdez – volume: 188 year: 1993 ident: 10.1016/j.ygeno.2021.06.035_bb0175 article-title: Demonstration of glutamate-like immunoreactivity at rat neuromuscular junctions by quantitative electron microscopic immunocytochemistry publication-title: Anat. Embryol. doi: 10.1007/BF00190144 contributor: fullname: Waerhaug – year: 2011 ident: 10.1016/j.ygeno.2021.06.035_bb0140 article-title: Mechanisms of exercise-induced mitochondrial biogenesis in skeletal muscle: implications for health and disease publication-title: Comprehen. Physiol. doi: 10.1002/cphy.c100074 contributor: fullname: Hood – volume: 50A year: 1995 ident: 10.1016/j.ygeno.2021.06.035_bb0150 article-title: Long-term resistance training in the elderly: effects on dynamic strength, exercise capacity, muscle, and bone publication-title: J. Gerontol. Ser. A Biol. Med. Sci. contributor: fullname: Mccartney – volume: 587 start-page: 211 year: 2009 ident: 10.1016/j.ygeno.2021.06.035_bb0035 article-title: Age-related differences in the dose-response relationship of muscle protein synthesis to resistance exercise in young and old men publication-title: J. Physiol. doi: 10.1113/jphysiol.2008.164483 contributor: fullname: Kumar – volume: 51 start-page: M270 year: 1996 ident: 10.1016/j.ygeno.2021.06.035_bb0040 article-title: Effect of age on muscle hypertrophy induced by resistance training publication-title: J. Gerontol. A Biol. Sci. Med. Sci. doi: 10.1093/gerona/51A.6.M270 contributor: fullname: Welle – volume: 101 start-page: 531 year: 2006 ident: 10.1016/j.ygeno.2021.06.035_bb0045 article-title: Efficacy of 3 days/wk resistance training on myofiber hypertrophy and myogenic mechanisms in young vs. older adults publication-title: J. Appl. Physiol. doi: 10.1152/japplphysiol.01474.2005 contributor: fullname: Kosek – volume: 116 start-page: 274 issue: 6 year: 2014 ident: 10.1016/j.ygeno.2021.06.035_bb0080 article-title: Time course-dependent changes in the transcriptome of human skeletal muscle during recovery from endurance exercise: from inflammation to adaptive remodeling publication-title: J. Appl. Physiol. (1985) doi: 10.1152/japplphysiol.00909.2013 contributor: fullname: Neubauer – volume: 95 start-page: 811 year: 1995 ident: 10.1016/j.ygeno.2021.06.035_bb0010 article-title: Physiologic hyperinsulinemia stimulates protein synthesis and enhances transport of selected amino acids in human skeletal muscle publication-title: J. Clin. Invest. doi: 10.1172/JCI117731 contributor: fullname: Biolo – volume: 116 start-page: 693 issue: 6 year: 2014 ident: 10.1016/j.ygeno.2021.06.035_bb0075 article-title: Resistance exercise training modulates acute gene expression during human skeletal muscle hypertrophy publication-title: J. Appl. Physiol. (1985) doi: 10.1152/japplphysiol.01366.2013 contributor: fullname: Nader – year: 2019 ident: 10.1016/j.ygeno.2021.06.035_bb0105 article-title: Moderate exercise improves function and increases adiponectin in the mdx mouse model of muscular dystrophy publication-title: Sci. Rep. doi: 10.1038/s41598-019-42203-z contributor: fullname: Zelikovich – volume: 12 issue: 9 year: 2016 ident: 10.1016/j.ygeno.2021.06.035_bb0050 article-title: The impact of endurance training on human skeletal muscle memory, global isoform expression and novel transcripts publication-title: PLoS Genet. doi: 10.1371/journal.pgen.1006294 contributor: fullname: Lindholm – volume: 15 year: 2014 ident: 10.1016/j.ygeno.2021.06.035_bb0125 article-title: Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 publication-title: Genome Biol. doi: 10.1186/s13059-014-0550-8 contributor: fullname: Love – volume: 115 year: 2018 ident: 10.1016/j.ygeno.2021.06.035_bb0170 article-title: Adult spinal motoneurons change their neurotransmitter phenotype to control locomotion publication-title: Proc. Natl. Acad. Sci. doi: 10.1073/pnas.1809050115 contributor: fullname: Bertuzzi – volume: 39 start-page: 343 year: 2009 ident: 10.1016/j.ygeno.2021.06.035_bb0165 article-title: Glutamate receptors localize postsynaptically at neuromuscular junctions in mice publication-title: Muscle Nerve doi: 10.1002/mus.21099 contributor: fullname: Mays – year: 2018 ident: 10.1016/j.ygeno.2021.06.035_bb0160 article-title: Metabolic networks influencing skeletal muscle fiber composition publication-title: Front. Cell. Dev. Biol. contributor: fullname: Julien – year: 2020 ident: 10.1016/j.ygeno.2021.06.035_bb5000 article-title: Loss of ARNT in skeletal muscle limits muscle regeneration in aging publication-title: The FASEB Journal doi: 10.1096/fj.202000761RR contributor: fullname: Endo – volume: 40 start-page: 223 year: 2008 ident: 10.1016/j.ygeno.2021.06.035_bb0020 article-title: Effect of exercise on serum sex hormones in men: a 12-month randomized clinical trial publication-title: Med. Sci. Sports Exerc. doi: 10.1249/mss.0b013e31815bbba9 contributor: fullname: Hawkins – volume: 2015 start-page: 1 year: 2015 ident: 10.1016/j.ygeno.2021.06.035_bb0190 article-title: Falls reduction and exercise training in an assisted living population publication-title: J. Aging Res. doi: 10.1155/2015/957598 contributor: fullname: Alvarez – volume: 112 start-page: 1625 issue: 10 year: 2012 ident: 10.1016/j.ygeno.2021.06.035_bb0085 article-title: Transcriptome signature of resistance exercise adaptations: mixed muscle and fiber type specific profiles in young and old adults publication-title: J. Appl. Physiol. (1985) doi: 10.1152/japplphysiol.00435.2011 contributor: fullname: Raue – volume: 36 start-page: 8783 year: 2016 ident: 10.1016/j.ygeno.2021.06.035_bb0185 article-title: Neuromuscular NMDA receptors modulate developmental synapse elimination publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.1181-16.2016 contributor: fullname: Personius – volume: 11 start-page: 659 year: 2010 ident: 10.1016/j.ygeno.2021.06.035_bb0065 article-title: Skeletal muscle gene expression in response to resistance exercise: sex specific regulation publication-title: BMC Genomics doi: 10.1186/1471-2164-11-659 contributor: fullname: Liu – volume: 2 start-page: 21 year: 2003 ident: 10.1016/j.ygeno.2021.06.035_bb0100 article-title: Neural control of aging skeletal muscle publication-title: Aging Cell doi: 10.1046/j.1474-9728.2003.00011.x contributor: fullname: Delbono – volume: 30 start-page: 923 year: 2013 ident: 10.1016/j.ygeno.2021.06.035_bb0120 article-title: featureCounts: an efficient general purpose program for assigning sequence reads to genomic features publication-title: Bioinformatics doi: 10.1093/bioinformatics/btt656 contributor: fullname: Liao – year: 2019 ident: 10.1016/j.ygeno.2021.06.035_bb0135 article-title: Development of an exercise training protocol to investigate arteriogenesis in a murine model of peripheral artery disease publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms20163956 contributor: fullname: Bresler – volume: 11 year: 2020 ident: 10.1016/j.ygeno.2021.06.035_bb0155 article-title: Optimizing skeletal muscle anabolic response to resistance training in aging publication-title: Front. Physiol. doi: 10.3389/fphys.2020.00874 contributor: fullname: Endo – year: 2012 ident: 10.1016/j.ygeno.2021.06.035_bb0145 article-title: Mitochondrial biogenesis in skeletal muscle: exercise and aging contributor: fullname: Damirchi – volume: 29 start-page: 15 year: 2012 ident: 10.1016/j.ygeno.2021.06.035_bb0115 article-title: STAR: ultrafast universal RNA-seq aligner publication-title: Bioinformatics doi: 10.1093/bioinformatics/bts635 contributor: fullname: Dobin |
SSID | ssj0009382 |
Score | 2.4374208 |
Snippet | Exercise is believed to be beneficial for skeletal muscle functions across all ages. Regimented exercise is often prescribed as an effective... |
SourceID | pubmedcentral proquest crossref pubmed elsevier |
SourceType | Open Access Repository Aggregation Database Index Database Publisher |
StartPage | 2965 |
SubjectTerms | Aging Aging - genetics Animals Differentially expressed genes Exercise Gene Expression Mice Muscle, Skeletal - metabolism Neuromuscular Junction - metabolism Sarcopenia Sarcopenia - genetics Sarcopenia - pathology Skeletal muscle |
Title | Exercise-induced gene expression changes in skeletal muscle of old mice |
URI | https://dx.doi.org/10.1016/j.ygeno.2021.06.035 https://www.ncbi.nlm.nih.gov/pubmed/34214629 https://search.proquest.com/docview/2548411417 https://pubmed.ncbi.nlm.nih.gov/PMC8403630 |
Volume | 113 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3db9MwED-NIQQ8TKwbUAaVkXjEaxOfk_hxrVbKBnthRX2z6sTWykc60VbaXva3c3aS0Y6JB56iOLZyvnPuQ7n7HcA7i66Q6JBjpnocnXV8GiWGSxc7oYyVSYBd_HyWjMZ4MpGTLRg0tTA-rbLW_ZVOD9q6HunW3OxezmbdL_R9kLONvgiFDHfsMUE9tqcv4pv0_wDvitAwyk_mfnaDPBRyvK49ECoFiXEUQDxDz7d7rdPf3ufdJMo1qzR8Bju1O8mOKop3YcuWLXhUNZi8bsHjQdPPrQVP16AH9-DDcd1riVNQTuItGBFpmb2qE2NLVpUEL9isZIvvZJzIS2c_Vwt6DZs7Nv9RMN_Jfh_Gw-PzwYjXTRV4jlIteRrbVKCLVYaZU5iIXmaczFWuIpsb5TKRZBhNRS-nV6PEokgNDeYJ7dSQBMVz2C7npX0JTDpH0VNujKOYrrCWFmNhRJZH6TQWpmjD-4aZ-rLCztBNUtk3HXivPe-1T60Tsg1Jw3C9cQQ0afd_L3zbiEcTT_0fj2lp56uFpuiXNhNhlLbhRSWuW0oE-p7msWpDuiHI2wkeeHvzSTm7CADcFBQLYtyr_yX4AJ74uypV7TVsL3-t7BvybZamAw8Ob6IOPDzqfz395K8fT0dnnXCkfwMjmv2x |
link.rule.ids | 230,315,786,790,891,3525,4521,24144,27602,27957,27958,45620,45698,45714,45909 |
linkProvider | Elsevier |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LTxsxEB6lQQh6QCUUGmjBSD1iJbse766PKIKGVy6AxM2Kd20RHpuoSaTy7xnvIyWl6qFXP2R7xjsP7fj7AL5bdJlEhxwT1eXorOPDIDJcutAJZayMCtjFq0HUv8XzO3nXgF79FsaXVVa2v7TphbWuWjqVNDuT0ahzTd8HBdvoH6GQ4w7xA6ygjANswsrx2UV_8Bt7VxScUX489xNq8KGizOvFY6FSnhgGBY5nQfv2Vwf1PgD9s47yjWM6_QQbVUTJjstNb0LD5i1YLTkmX1qw1qsp3Vrw8Q364Bb8OKnoljjl5aThjNEmLbO_qtrYnJWvgqdslLPpI_knCtTZ83xKy7CxY-OnjHky-89we3py0-vzileBpyjVjMehjQW6UCWYOIWR6CbGyVSlKrCpUS4RUYLBUHRTWholZllsqDGN6KSGlCi2oZmPc_sFmHSOEqjUGEdpXWYtTcbMiCQN4mEoTNaGo1qYelLCZ-i6ruxBF7LXXvbaV9cJ2YaoFrheugWaDPy_Jx7W6tEkU__TY5jb8XyqKQGmwwQYxG3YKdW12IlAT2seqjbES4pcDPDY28s9-ei-wOCmvFiQ4Hb_d8MHsNa_ubrUl2eDiz1Y9z1l5dpXaM5-zu03CnVmZr-6yq_eJP3H |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Exercise-induced+gene+expression+changes+in+skeletal+muscle+of+old+mice&rft.jtitle=Genomics+%28San+Diego%2C+Calif.%29&rft.au=Endo%2C+Yori&rft.au=Zhang%2C+Yuteng&rft.au=Olumi%2C+Shayan&rft.au=Karvar%2C+Mehran&rft.date=2021-09-01&rft.eissn=1089-8646&rft.volume=113&rft.issue=5&rft.spage=2965&rft.epage=2976&rft_id=info:doi/10.1016%2Fj.ygeno.2021.06.035&rft.externalDBID=NO_FULL_TEXT |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0888-7543&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0888-7543&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0888-7543&client=summon |