Deep Analysis of the Peripheral Immune System in IBD Reveals New Insight in Disease Subtyping and Response to Monotherapy or Combination Therapy

• Published in: Cellular and molecular gastroenterology and hepatology Vol. 12; no. 2; pp. 599 - 632
• Main Authors: Kosoy, Roman, Kim-Schulze, Seunghee, Rahman, Adeeb, Friedman, Joshua R., Huang, Ruiqi, Peters, Lauren A., Amir, El-ad, Perrigoue, Jacqueline, Stojmirovic, Aleksandar, Song, Won-min, Ke, Hao, Ungaro, Ryan, Mehandru, Saurabh, Cho, Judy, Dubinsky, Marla, Curran, Mark, Brodmerkel, Carrie, Schadt, Eric E., Sands, Bruce E., Colombel, Jean-Frederic, Kasarskis, Andrew, Argmann, Carmen A., Suárez-Fariñas, Mayte
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2021; Elsevier
• Subjects: Adult; Anti-TNF; B-Lymphocytes - immunology; Case-Control Studies; Cohort Studies; Colitis, Ulcerative - blood; Colitis, Ulcerative - diagnosis; Colitis, Ulcerative - immunology; Colitis, Ulcerative - therapy; Combined Modality Therapy; Crohn Disease - blood; Crohn Disease - diagnosis; Crohn Disease - immunology; Crohn Disease - therapy; CyTOF; FACS; Female; Humans; Immune System - pathology; Immunophenotype; Immunophenotyping; Inflammatory Bowel Diseases - blood; Inflammatory Bowel Diseases - diagnosis; Inflammatory Bowel Diseases - immunology; Inflammatory Bowel Diseases - therapy; Male; Mercaptopurine - therapeutic use; Middle Aged; Original Research; Severity of Illness Index; Surveys and Questionnaires; T-Lymphocytes - immunology; Thiopurine; Tumor Necrosis Factor-alpha - antagonists & inhibitors; Immunophenotype; CBC; IBD; FACS; TNF; HBI; UC; AUC; Th; FDR; NLR; CD; Treg; Anti-TNF; AZA; EM; SCCAI; UCEIS; MSCCR; PCA; MayoEndo; Thiopurine; SES-CD; CyTOF; NK; ADA; DC

Inflammatory bowel disease (IBD) is a complex disease with variable presentation, progression, and response to therapies. Current disease classification is based on subjective clinical phenotypes. The peripheral blood immunophenome can reflect local inflammation, and thus we measured 39 circulating...