Caspase Cleavage of Gelsolin Is an Inductive Cue for Pathologic Cardiac Hypertrophy

• Published in: Journal of the American Heart Association Vol. 7; no. 23; p. e010404
• Main Authors: Putinski, Charis, Abdul‐Ghani, Mohammad, Brunette, Steve, Burgon, Patrick G., Megeney, Lynn A.
• Format: Journal Article
• Language: English
• Published: England John Wiley and Sons Inc 04.12.2018; Wiley
• Subjects: Animals; cardiac hypertrophy; Cardiomegaly - etiology; Cardiomegaly - metabolism; cardiomyocyte hypertrophy; Caspase 3 - metabolism; caspase‐3; cell signaling; cytoskeletal dynamics; Fluorescent Antibody Technique; gelsolin; Gelsolin - metabolism; Gene Knockdown Techniques; Male; Myocytes, Cardiac - metabolism; Original Research; Rats; Rats, Sprague-Dawley; cytoskeletal dynamics; cardiomyocyte hypertrophy; cardiac hypertrophy; gelsolin; cell signaling; caspase‐3

Background Cardiac hypertrophy is an adaptive remodeling event that may improve or diminish contractile performance of the heart. Physiologic and pathologic hypertrophy yield distinct outcomes, yet both are dependent on caspase-directed proteolysis. This suggests that each form of myocardial growth...