Transcranial alternating current stimulation with speech envelopes modulates speech comprehension

• Published in: NeuroImage (Orlando, Fla.) Vol. 172; pp. 766 - 774
• Main Authors: Wilsch, Anna, Neuling, Toralf, Obleser, Jonas, Herrmann, Christoph S.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.05.2018; Elsevier Limited
• Subjects: Acoustic Stimulation; Acoustics; Adult; Auditory Cortex - physiology; Auditory perception; Auditory stimuli; Comprehension - physiology; Cortex (auditory); Cortical entrainment; Entrainment; Envelopes; Excitability; Female; Humans; Male; Neural oscillations; Noise; Non-invasive brain stimulation; Oscillations; Speech; Speech intelligibility; Speech perception; Speech Perception - physiology; Studies; Temporal lobe; Theta rhythms; Transcranial Direct Current Stimulation; Transcranial electric stimulation; Young Adult; Transcranial electric stimulation; Non-invasive brain stimulation; Neural oscillations; Cortical entrainment; Speech intelligibility
• ISSN: 1053-8119; 1095-9572; 1095-9572
• DOI: 10.1016/j.neuroimage.2018.01.038

Cortical entrainment of the auditory cortex to the broadband temporal envelope of a speech signal is crucial for speech comprehension. Entrainment results in phases of high and low neural excitability, which structure and decode the incoming speech signal. Entrainment to speech is strongest in the theta frequency range (4–8 Hz), the average frequency of the speech envelope. If a speech signal is degraded, entrainment to the speech envelope is weaker and speech intelligibility declines. Besides perceptually evoked cortical entrainment, transcranial alternating current stimulation (tACS) entrains neural oscillations by applying an electric signal to the brain. Accordingly, tACS-induced entrainment in auditory cortex has been shown to improve auditory perception. The aim of the current study was to modulate speech intelligibility externally by means of tACS such that the electric current corresponds to the envelope of the presented speech stream (i.e., envelope-tACS). Participants performed the Oldenburg sentence test with sentences presented in noise in combination with envelope-tACS. Critically, tACS was induced at time lags of 0–250 ms in 50-ms steps relative to sentence onset (auditory stimuli were simultaneous to or preceded tACS). We performed single-subject sinusoidal, linear, and quadratic fits to the sentence comprehension performance across the time lags. We could show that the sinusoidal fit described the modulation of sentence comprehension best. Importantly, the average frequency of the sinusoidal fit was 5.12 Hz, corresponding to the peaks of the amplitude spectrum of the stimulated envelopes. This finding was supported by a significant 5-Hz peak in the average power spectrum of individual performance time series. Altogether, envelope-tACS modulates intelligibility of speech in noise, presumably by enhancing and disrupting (time lag with in- or out-of-phase stimulation, respectively) cortical entrainment to the speech envelope in auditory cortex. •Envelope-tACS modulates entrainment to ongoing speech signal.•Time lag between speech onset and auditory-cortex response differs individually.•Varying time lags between speech onset and tACS modulate comprehension sinusoidally.•First evidence for possible clinical application of envelope-tACS for hearing loss.