CDKN2A Copy Number Loss Is an Independent Prognostic Factor in HPV-Negative Head and Neck Squamous Cell Carcinoma

• Published in: Frontiers in oncology Vol. 8; p. 95
• Main Authors: Chen, William S., Bindra, Ranjit S., Mo, Allen, Hayman, Thomas, Husain, Zain, Contessa, Joseph N., Gaffney, Stephen G., Townsend, Jeffrey P., Yu, James B.
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 04.04.2018
• Subjects: CDKN2A; genomics and genetics; head and neck neoplasms; Oncology; outcomes assessment; prognostic biomarkers; head and neck neoplasms; prognostic biomarkers; outcomes assessment; genomics and genetics; CDKN2A

HPV infection is associated with high p16 expression and good prognosis in head and neck squamous cell carcinomas (HNSCCs). Analysis of CDKN2A, the gene encoding p16, may further elucidate the association between p16 expression and prognosis. We sought to determine whether CDKN2A copy number loss wa...