Immune regulation of intestinal-stem-cell function in Drosophila

• Published in: Stem cell reports Vol. 17; no. 4; pp. 741 - 755
• Main Authors: Shin, Minjeong, Ferguson, Meghan, Willms, Reegan J., Jones, Lena O., Petkau, Kristina, Foley, Edan
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 12.04.2022; Elsevier
• Subjects: Animals; differentiation; Drosophila; Drosophila - physiology; Drosophila melanogaster; Drosophila Proteins - genetics; Homeostasis; IMD; immunity; intestinal stem cell; Intestines; proliferation; Stem Cells; IMD; intestinal stem cell; differentiation; immunity; proliferation; Drosophila

Intestinal progenitor cells integrate signals from their niche, and the gut lumen, to divide and differentiate at a rate that maintains an epithelial barrier to microbial invasion of the host interior. Despite the importance of evolutionarily conserved innate immune defenses to maintain stable host-...