Long-Term Medication Adherence Trajectories to Direct Oral Anticoagulants and Clinical Outcomes in Patients With Atrial Fibrillation

• Published in: Journal of the American Heart Association Vol. 10; no. 21; p. e021601
• Main Authors: An, Jaejin, Bider, Zoe, Luong, Tiffany Q, Cheetham, T Craig, Lang, Daniel T, Fischer, Heidi, Reynolds, Kristi
• Format: Journal Article
• Language: English
• Published: England John Wiley and Sons Inc 02.11.2021; Wiley
• Subjects: Administration, Oral; anticoagulant; Anticoagulants - adverse effects; atrial fibrillation; Atrial Fibrillation - complications; Atrial Fibrillation - diagnosis; Atrial Fibrillation - drug therapy; Hemorrhage - chemically induced; Hemorrhage - epidemiology; Humans; Medication Adherence; Original Research; Stroke - drug therapy; Stroke - epidemiology; Stroke - prevention & control; Thromboembolism - drug therapy; Thromboembolism - epidemiology; Thromboembolism - prevention & control; atrial fibrillation; anticoagulant; medication adherence

Background Direct oral anticoagulants (DOACs) are widely used in patients with nonvalvular atrial fibrillation for stroke prevention. However, long-term adherence to DOACs and clinical outcomes in real-world clinical practice is not well understood. This study evaluated long-term medication adherenc...