Overexpression of a fish CDKN2 gene in a hereditary melanoma model

• Published in: Carcinogenesis (New York) Vol. 21; no. 4; pp. 599 - 605
• Main Authors: Kazianis, Steven, Coletta, Luis Della, Morizot, Donald C., Johnston, Dennis A., Osterndorff, Elizabeth A., Nairn, Rodney S.
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.04.2000; Oxford Publishing Limited (England)
• Subjects: Animal tumors. Experimental tumors; Animals; Biological and medical sciences; CDKN2A gene; CDKN2B gene; CDKN2X gene; CpG Islands; Cyclin-Dependent Kinase Inhibitor p16 - genetics; Cyprinodontiformes; DNA Methylation; Female; Fish Diseases - genetics; Genes, Tumor Suppressor; INK4A gene; Medical sciences; Melanoma - genetics; Melanoma - veterinary; MTS1 gene; P16 gene; Promoter Regions, Genetic; RNA - analysis; Spontaneous animal tumors; Tumors; Xiphophorus; Xmrk-2 gene; Animal model; Skin disease; Enzyme; Transcription promoter; Transferases; Spontaneous; Enzyme inhibitor; Gene overexpression; Malignant tumor; Gene expression; Hereditary; Carcinogenesis; CDKN2 gene; Vertebrata; Protein kinase; Animal; DNA; Pisces; Malignant melanoma; Cytosine; Methylation; Tumor suppressor gene; Phenotypic hybrid

The fish genus Xiphophorus provides a vertebrate model useful in etiological studies of cancer. Hybrid fish can spontaneously develop melanomas deriving from the inheritance of melanistic pigment patterns and the simultaneous absence of proper genetic regulation. A cyclin-dependent kinase inhibitor...