KV Channel-Interacting Proteins in the Neurological and Cardiovascular Systems: An Updated Review

• Published in: Cells (Basel, Switzerland) Vol. 12; no. 14; p. 1894
• Main Authors: Wu, Le-Yi, Song, Yu-Juan, Zhang, Cheng-Lin, Liu, Jie
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 20.07.2023; MDPI
• Subjects: Adrenergic receptors; Alzheimer's disease; Amyotrophic lateral sclerosis; Brain research; Cardiomyocytes; Cardiovascular diseases; Cell activation; Cell membranes; Channel gating; Circadian rhythms; EF-hand; Epilepsy; Excitability; Gene regulation; Heart; Huntingtons disease; Immune system; Immunological memory; Inflammation; Kinases; KV channel; KV channel-interacting proteins; Localization; N-Terminus; Neurodegenerative diseases; neurodegenerative disorders; Phosphorylation; Physiology; Potassium channels (voltage-gated); Proteins; Review; Reviews; Transcription factors

KV channel-interacting proteins (KChIP1-4) belong to a family of Ca2+-binding EF-hand proteins that are able to bind to the N-terminus of the KV4 channel α-subunits. KChIPs are predominantly expressed in the brain and heart, where they contribute to the maintenance of the excitability of neurons and...