Protective effects of a novel drug RC28-E blocking both VEGF and FGF2 on early diabetic rat retina

• Published in: International journal of ophthalmology Vol. 11; no. 6; pp. 935 - 944
• Main Authors: Yang, Qian-Hui, Zhang, Yan, Jiang, Jing, Wu, Mian-Mian, Han, Qian, Bo, Qi-Yu, Yu, Guang-Wei, Ru, Yu-Sha, Liu, Xun, Huang, Min, Wang, Ling, Zhang, Xiao-Min, Fang, Jian-Min, Li, Xiao-Rong
• Format: Journal Article
• Language: English
• Published: China International Journal of Ophthalmology Press 18.06.2018; Press of International Journal of Ophthalmology (IJO PRESS)
• Subjects: Basic Research; diabetes; diabetic retinopathy; fibroblast growth factor 2; recombinant decoy receptor; retinal damage; vascular endothelial growth factor; diabetic retinopathy; diabetes; retinal damage; fibroblast growth factor 2; recombinant decoy receptor; vascular endothelial growth factor

To investigate protective effects of a novel recombinant decoy receptor drug RC28-E on retinal damage in early diabetic rats. The streptozotocin (STZ)-induced diabetic rats were randomly divided into 6 groups: diabetes mellitus (DM) group (saline, 3 µL/eye); RC28-E at low (0.33 µg/µL, 3 µL), medium...