Antibodies to the human 60 kDa heat-shock protein in patients with schizophrenia

• Published in: The Lancet (British edition) Vol. 340; no. 8819; pp. 569 - 572
• Main Authors: Kilidireas, K., Sadiq, S.A., Gorig, A.D., Latov, N., Strauss, D.H., Hashim, G.A., Gorman, J.M.
• Format: Journal Article
• Language: English
• Published: London Elsevier Ltd 05.09.1992; Lancet; Elsevier Limited
• Subjects: Adult and adolescent clinical studies; Antibodies - analysis; Antibody Formation; Biological and medical sciences; Blotting, Western; Cell Line; Cross Reactions; Heat-Shock Proteins - chemistry; Heat-Shock Proteins - immunology; Humans; Immune response; Immunity (Disease); Immunoglobulin G - analysis; Medical research; Medical sciences; Mental disorders; Neuroblastoma - immunology; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychoses; Schizophrenia; Schizophrenia - blood; Schizophrenia - immunology; Schizophrenia - metabolism; Human; Psychosis; Antibody; Immunological investigation; Heat shock protein; Schizophrenia; Psychopathology; Biological psychiatry

Immune mechanisms are thought to be important in a subpopulation of patients with schizophrenia. We examined the specificity of neural antibodies in patients with schizophrenia to identify a possible antigen. Serum antibodies from patients with schizophrenia and control subjects were tested for bind...