Mesothelial cell-derived antigen-presenting cancer-associated fibroblasts induce expansion of regulatory T cells in pancreatic cancer

• Published in: Cancer cell Vol. 40; no. 6; pp. 656 - 673.e7
• Main Authors: Huang, Huocong, Wang, Zhaoning, Zhang, Yuqing, Pradhan, Rachana N., Ganguly, Debolina, Chandra, Raghav, Murimwa, Gilbert, Wright, Steven, Gu, Xiaowu, Maddipati, Ravikanth, Müller, Sören, Turley, Shannon J., Brekken, Rolf A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 13.06.2022
• Subjects: cancer-associated fibroblast; Cancer-Associated Fibroblasts - metabolism; Fibroblasts; Humans; mesothelial cell; mesothelin; pancreatic cancer; Pancreatic Neoplasms - pathology; regulatory T cell; T-Lymphocytes, Regulatory; Transforming Growth Factor beta - metabolism; cancer-associated fibroblast; pancreatic cancer; mesothelial cell; regulatory T cell; mesothelin

Recent studies have identified a unique cancer-associated fibroblast (CAF) population termed antigen-presenting CAFs (apCAFs), characterized by the expression of major histocompatibility complex class II molecules, suggesting a function in regulating tumor immunity. Here, by integrating multiple sin...