External Beam Radiation Therapy and Enadenotucirev: Inhibition of the DDR and Mechanisms of Radiation-Mediated Virus Increase

• Published in: Cancers Vol. 12; no. 4; p. 798
• Main Authors: Pokrovska, Tzveta D, Jacobus, Egon J, Puliyadi, Rathi, Prevo, Remko, Frost, Sally, Dyer, Arthur, Baugh, Richard, Rodriguez-Berriguete, Gonzalo, Fisher, Kerry, Granata, Giovanna, Herbert, Katharine, Taverner, William K, Champion, Brian R, Higgins, Geoff S, Seymour, Len W, Lei-Rossmann, Janet
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI 26.03.2020; MDPI AG
• Subjects: combination therapy; dna damage repair; ionizing radiation; oncolytic viruses; radiotherapy; virotherapy; radiotherapy; DNA damage repair; combination therapy; oncolytic viruses; virotherapy; ionizing radiation

Ionising radiation causes cell death through the induction of DNA damage, particularly double-stranded DNA (dsDNA) breaks. Evidence suggests that adenoviruses inhibit proteins involved in the DNA damage response (DDR) to prevent recognition of double-stranded viral DNA genomes as cellular dsDNA brea...