Lateral Lymph Node Metastases in Locally Advanced Low Rectal Cancers May Not Be Treated Effectively With Neoadjuvant (Chemo)Radiotherapy Only

• Published in: Frontiers in oncology Vol. 9; p. 1355
• Main Authors: Haanappel, Anouck, Kroon, Hidde M, Schaap, Dennis P, Bedrikovetski, Sergei, Dudi-Venkata, Nagendra N, Lee, Hong X, Thomas, Michelle L, Liu, Jianliang, van der Valk, Maxime J M, Rutten, Harm J T, Beets, Geerard L, Kusters, Miranda, Sammour, Tarik
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 03.12.2019
• Subjects: lateral lymph nodes; locally advanced low rectal cancer; neoadjuvant (chemo)radiotherapy; oncological outcomes; Oncology; survival; oncological outcomes; neoadjuvant (chemo)radiotherapy; lateral lymph nodes; locally advanced low rectal cancer; survival

In the West, pre-treatment abnormal lateral lymph nodes (LLN+) in patients with a low locally advanced rectal cancer (AJCC Stage III), are treated with neoadjuvant (chemo)radiotherapy (nCRT), without a lateral lymph node dissection (LLND). It has been suggested, however, that LLN+ patients have high...