Involvement of Glutathione Depletion in Selective Cytotoxicity of Oridonin to p53-Mutant Esophageal Squamous Carcinoma Cells

• Published in: Frontiers in oncology Vol. 9; p. 1525
• Main Authors: Li, Yinchao, Li, Nana, Shi, Jianxiang, Ahmed, Tanzeel, Liu, Hongmin, Guo, Jiancheng, Tang, Wenxue, Guo, Yongjun, Zhang, Qi
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 15.01.2020
• Subjects: esophageal squamous cell carcinoma cells; glutathione; Oncology; oridonin; p53-mutation; RNA seq; oridonin; RNA seq; p53-mutation; esophageal squamous cell carcinoma cells; glutathione

Oridonin, a diterpenoid compound isolated from traditional Chinese medicine Rabdosia rubescens, has shown antitumor effects to esophageal cancer. However, its molecular mechanism is not fully understood, which limits its clinical application. In the present study, we used RNA-seq analysis to check t...