Protective effect of dietary chitosan on cadmium accumulation in rats

Cadmium is a toxic metal that is an occupational and environmental concern especially because of its human carcinogenicity; it induces serious adverse effects in various organs and tissues. Even low levels of exposure to cadmium could be harmful owing to its extremely long half-life in the body. Cad...

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Published inNutrition research and practice Vol. 10; no. 1; pp. 19 - 25
Main Authors Kim, Mi Young, Shon, Woo-Jeong, Park, Mi-Na, Lee, Yeon-Sook, Shin, Dong-Mi
Format Journal Article
LanguageEnglish
Published Korea (South) 한국영양학회 01.02.2016
The Korean Nutrition Society and the Korean Society of Community Nutrition
Subjects
Original Research
생활과학
cadmium
bone disorder
mineral metabolism
Chitosan
liver function
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Abstract Cadmium is a toxic metal that is an occupational and environmental concern especially because of its human carcinogenicity; it induces serious adverse effects in various organs and tissues. Even low levels of exposure to cadmium could be harmful owing to its extremely long half-life in the body. Cadmium intoxication may be prevented by the consumption of dietary components that potentially reduce its accumulation in the body. Dietary chitosan is a polysaccharide derived from animal sources; it has been known for its ability to bind to divalent cations including cadmium, in addition to other beneficial effects including hypocholesterolemic and anticancer effects. Therefore, we aimed to investigate the role of dietary chitosan in reducing cadmium accumulation using an in vivo system. Cadmium was administered orally at 2 mg (three times per week) to three groups of Sprague-Dawley rats: control, low-dose, and high-dose (0, 3, and 5%, respectively) chitosan diet groups for eight weeks. Cadmium accumulation, as well as tissue functional and histological changes, was determined. Compared to the control group, rats fed the chitosan diet showed significantly lower levels of cadmium in blood and tissues including the kidneys, liver, and femur. Biochemical analysis of liver function including the determination of aspartate aminotransferase and total bilirubin levels showed that dietary chitosan reduced hepatic tissue damage caused by cadmium intoxication and prevented the associated bone disorder. These results suggest that dietary chitosan has the potential to reduce cadmium accumulation in the body as well as protect liver function and bone health against cadmium intoxication.
AbstractList BACKGROUND/OBJECTIVESCadmium is a toxic metal that is an occupational and environmental concern especially because of its human carcinogenicity; it induces serious adverse effects in various organs and tissues. Even low levels of exposure to cadmium could be harmful owing to its extremely long half-life in the body. Cadmium intoxication may be prevented by the consumption of dietary components that potentially reduce its accumulation in the body. Dietary chitosan is a polysaccharide derived from animal sources; it has been known for its ability to bind to divalent cations including cadmium, in addition to other beneficial effects including hypocholesterolemic and anticancer effects. Therefore, we aimed to investigate the role of dietary chitosan in reducing cadmium accumulation using an in vivo system. MATERIALS/METHODSCadmium was administered orally at 2 mg (three times per week) to three groups of Sprague-Dawley rats: control, low-dose, and high-dose (0, 3, and 5%, respectively) chitosan diet groups for eight weeks. Cadmium accumulation, as well as tissue functional and histological changes, was determined. RESULTSCompared to the control group, rats fed the chitosan diet showed significantly lower levels of cadmium in blood and tissues including the kidneys, liver, and femur. Biochemical analysis of liver function including the determination of aspartate aminotransferase and total bilirubin levels showed that dietary chitosan reduced hepatic tissue damage caused by cadmium intoxication and prevented the associated bone disorder. CONCLUSIONSThese results suggest that dietary chitosan has the potential to reduce cadmium accumulation in the body as well as protect liver function and bone health against cadmium intoxication.
Cadmium is a toxic metal that is an occupational and environmental concern especially because of its human carcinogenicity; it induces serious adverse effects in various organs and tissues. Even low levels of exposure to cadmium could be harmful owing to its extremely long half-life in the body. Cadmium intoxication may be prevented by the consumption of dietary components that potentially reduce its accumulation in the body. Dietary chitosan is a polysaccharide derived from animal sources; it has been known for its ability to bind to divalent cations including cadmium, in addition to other beneficial effects including hypocholesterolemic and anticancer effects. Therefore, we aimed to investigate the role of dietary chitosan in reducing cadmium accumulation using an in vivo system. Cadmium was administered orally at 2 mg (three times per week) to three groups of Sprague-Dawley rats: control, low-dose, and high-dose (0, 3, and 5%, respectively) chitosan diet groups for eight weeks. Cadmium accumulation, as well as tissue functional and histological changes, was determined. Compared to the control group, rats fed the chitosan diet showed significantly lower levels of cadmium in blood and tissues including the kidneys, liver, and femur. Biochemical analysis of liver function including the determination of aspartate aminotransferase and total bilirubin levels showed that dietary chitosan reduced hepatic tissue damage caused by cadmium intoxication and prevented the associated bone disorder. These results suggest that dietary chitosan has the potential to reduce cadmium accumulation in the body as well as protect liver function and bone health against cadmium intoxication.
BACKGROUND/OBJECTIVES: Cadmium is a toxic metal that is an occupational and environmental concern especially becauseof its human carcinogenicity; it induces serious adverse effects in various organs and tissues. Even low levels of exposureto cadmium could be harmful owing to its extremely long half-life in the body. Cadmium intoxication may be preventedby the consumption of dietary components that potentially reduce its accumulation in the body. Dietary chitosan is a polysaccharidederived from animal sources; it has been known for its ability to bind to divalent cations including cadmium, in additionto other beneficial effects including hypocholesterolemic and anticancer effects. Therefore, we aimed to investigate the roleof dietary chitosan in reducing cadmium accumulation using an in vivo system. MATERIALS/METHODS: Cadmium was administered orally at 2 mg (three times per week) to three groups of Sprague-Dawleyrats: control, low-dose, and high-dose (0, 3, and 5%, respectively) chitosan diet groups for eight weeks. Cadmium accumulation,as well as tissue functional and histological changes, was determined. RESULTS: Compared to the control group, rats fed the chitosan diet showed significantly lower levels of cadmium in bloodand tissues including the kidneys, liver, and femur. Biochemical analysis of liver function including the determination of aspartateaminotransferase and total bilirubin levels showed that dietary chitosan reduced hepatic tissue damage caused by cadmiumintoxication and prevented the associated bone disorder. CONCLUSIONS: These results suggest that dietary chitosan has the potential to reduce cadmium accumulation in the bodyas well as protect liver function and bone health against cadmium intoxication. KCI Citation Count: 9
Author Dong-Mi Shin
Mi Young Kim
Yeon-Sook Lee
Mi-Na Park
Woo-Jeong Shon
AuthorAffiliation 2 Research institution of human ecology, Seoul National University,1 Gwanak-ro, Gwanak-gu, Seoul 08826, Korea
1 Department of Food and Nutrition, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Korea
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Issue 1
Keywords cadmium
bone disorder
mineral metabolism
Chitosan
liver function
Language English
License This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Snippet Cadmium is a toxic metal that is an occupational and environmental concern especially because of its human carcinogenicity; it induces serious adverse effects...
BACKGROUND/OBJECTIVESCadmium is a toxic metal that is an occupational and environmental concern especially because of its human carcinogenicity; it induces...
BACKGROUND/OBJECTIVES: Cadmium is a toxic metal that is an occupational and environmental concern especially becauseof its human carcinogenicity; it induces...
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Title Protective effect of dietary chitosan on cadmium accumulation in rats
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