Proteomic Landscape of Exosomes Reveals the Functional Contributions of CD151 in Triple-Negative Breast Cancer

• Published in: Molecular & cellular proteomics Vol. 20; p. 100121
• Main Authors: Li, Sipeng, Li, Xinya, Yang, Siqi, Pi, Hao, Li, Zheyi, Yao, Pengju, Zhang, Qi, Wang, Qingsong, Shen, Pingping, Li, Xizhou, Ji, Jianguo
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2021; American Society for Biochemistry and Molecular Biology
• Subjects: Adult; Aged; Aged, 80 and over; Cell Line, Tumor; exosomal CD151; exosomes; Exosomes - metabolism; Female; Humans; Middle Aged; Protein Interaction Maps; Proteome - metabolism; proteomics; Tetraspanin 24 - genetics; Tetraspanin 24 - metabolism; TNBC; Triple Negative Breast Neoplasms - blood; Triple Negative Breast Neoplasms - metabolism; proteomics; TBST; exosomal CD151; DEP; PD; FDR; exosomes; FBS; NTA; TMT; TNBC; HER2; FC; TEM

Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer. Patients with TNBC have poor overall survival because of limited molecular therapeutic targets. Recently, exosomes have been recognized as key mediators in cancer progression, but the molecular components and function of...