The γ-parameter of anomalous diffusion quantified in human brain by MRI depends on local magnetic susceptibility differences

• Published in: NeuroImage (Orlando, Fla.) Vol. 147; pp. 619 - 631
• Main Authors: Caporale, A., Palombo, M., Macaluso, E., Guerreri, M., Bozzali, M., Capuani, S.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.02.2017; Elsevier Limited
• Subjects: Alzheimer's disease; Anisotropy; Anomalous diffusion imaging; Brain; DTI; Iron; Magnetic fields; Magnetic resonance imaging; Magnetic susceptibility; Magnetic susceptibility difference; Multiple sclerosis; Myelin; Neurodegenerative diseases; Neuroimaging; NMR; Nuclear magnetic resonance; Standard error of measurement; Therapeutic applications; R2; AD; GM; Iron; ROI; SD; VOI; DW; T2WIs; WM; DTI; SEM; Magnetic susceptibility difference; Anomalous diffusion imaging; R

Motivated by previous results obtained in vitro, we investigated the dependence of the anomalous diffusion (AD) MRI technique on local magnetic susceptibility differences (Δχ) driven by magnetic field inhomogeneity in human brains. The AD-imaging contrast investigated here is quantified by the stret...