Identification of Genetic Mutations in Cancer: Challenge and Opportunity in the New Era of Targeted Therapy

• Published in: Frontiers in oncology Vol. 9; p. 263
• Main Authors: Jin, Jing, Wu, Xu, Yin, Jianhua, Li, Mingxing, Shen, Jing, Li, Jing, Zhao, Yueshui, Zhao, Qijie, Wu, Jingbo, Wen, Qinglian, Cho, Chi Hin, Yi, Tao, Xiao, Zhangang, Qu, Liping
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 16.04.2019
• Subjects: cyclin-dependent kinases 4/6; EGFR; Oncology; PD-1/PD-L1; resistance; somatic mutation; targeted therapy; targeted therapy; cyclin-dependent kinases 4/6; somatic mutation; PD-1/PD-L1; EGFR; resistance

The introduction of targeted therapy is the biggest success in the treatment of cancer in the past few decades. However, heterogeneous cancer is characterized by diverse molecular alterations as well as multiple clinical profiles. Specific genetic mutations in cancer therapy targets may increase dru...