Computer-controlled infusion of ORG 21465, a water soluble steroid i.v. anaesthetic agent, into human volunteers

• Published in: British journal of anaesthesia : BJA Vol. 79; no. 4; pp. 433 - 439
• Main Authors: Sneyd, J R, Wright, P M, Harris, D, Taylor, P A, Vijn, P C, Cross, M, Dale, H, Voortman, G, Boen, P
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 01.10.1997; Oxford University Press; Oxford Publishing Limited (England)
• Subjects: Adult; Anesthesia, Intravenous; Anesthetics, Intravenous - administration & dosage; Anesthetics, Intravenous - pharmacokinetics; Anesthetics, Intravenous - pharmacology; Anesthetics. Neuromuscular blocking agents; Biological and medical sciences; Drug Therapy, Computer-Assisted; Electroencephalography - drug effects; Electromyography - drug effects; Humans; Infusions, Intravenous; Male; Medical sciences; Neuropharmacology; Pharmacology. Drug treatments; Pregnanediones - pharmacokinetics; Pregnanediones - pharmacology; Solubility; Water; Human; Steroid; Intravenous administration; General anesthetic; Activity concentration relation; General anesthesia; Sedation; Normal; Pharmacokinetics; Computer aid; Monitoring

ORG 21465 has been found to possess anaesthetic properties in humans and its pharmacokinetics are known. We performed this study to confirm the characteristics associated with its administration and to define its pharmacodynamic profile, in particular to explore the relationship between sedation, an...