Sixteen‐Week Physical Activity Intervention in Subjects With Increased Cardiometabolic Risk Shifts Innate Immune Function Towards a Less Proinflammatory State

• Published in: Journal of the American Heart Association Vol. 8; no. 21; p. e013764
• Main Authors: Noz, Marlies P., Hartman, Yvonne A. W., Hopman, Maria T. E., Willems, Peter H. G. M., Tack, Cees J., Joosten, Leo A. B., Netea, Mihai G., Thijssen, Dick H. J., Riksen, Niels P.
• Format: Journal Article
• Language: English
• Published: England John Wiley and Sons Inc 05.11.2019; Wiley
• Subjects: Aged; atherosclerosis; cardiovascular disease; Cardiovascular Diseases - epidemiology; Cardiovascular Diseases - immunology; Cardiovascular Diseases - metabolism; Cardiovascular Diseases - prevention & control; Exercise; Female; Humans; Immunity, Innate - physiology; Inflammation - immunology; Inflammation - prevention & control; innate immunity; Leukocytes, Mononuclear - metabolism; Male; Middle Aged; Monocytes - metabolism; Original Research; physical activity; Risk Factors; sedentary behavior; Time Factors; atherosclerosis; cardiovascular disease; innate immunity; sedentary behavior; physical activity

Background Low-grade inflammation, largely mediated by monocyte-derived macrophages, contributes to atherosclerosis. Sedentary behavior is associated with atherosclerosis and cardiovascular diseases (CVD). We examined whether reducing sedentary behavior and improving walking time improves monocyte i...